Protein Alignment bdg and SLC6A8

DIOPT Version :10

• Sequence 1: NP_611064.2
• Gene: bdg / 36747
• FlyBaseID: FBgn0034049
• Length: 1331
• Species: Drosophila melanogaster
• Sequence 2: NP_005620.1
• Gene: SLC6A8 / 6535
• HGNCID: 11055
• Length: 635
• Species: Homo sapiens
• Alignment Length: 627
• Identity: 148/627 - (23%)
• Similarity: 257/627 - (40%)
• Gaps: 122/627 - (19%)

  Fly   497 WPHAGSRTLALIGCTLGVFNMCRFAVLTI-NFGGNFLLQFLLLSVIFGIPLLWLQMCLGAKIRAG 560
            |.......::.:|..:|:.|:.||..|.. |.||.||:.::|::::.|||:.:|::.||..::||
Human    55 WTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAG 119

  Fly   561 PVSMWKISPICAGVGIALVMQQCFLALYSTVSLAWILVYLRDVFPTA---ARSGYRWQ--EMAFP 620
            .:::|.|.|:..|:|.|.::...:...|..:.|||...||...|.|.   |..|:.|.  :....
Human   120 SINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEI 184

  Fly   621 YRY-DASNAT-GNLT--------QTVAEYFNVVVLQRLHLANHPDASGIRFHVNDRQLAFYLALI 675
            :|: |.:||: .|||        ..|.|::...||:   |:...:..|    ..:.::...|...
Human   185 FRHEDCANASLANLTCDQLADRRSPVIEFWENKVLR---LSGGLEVPG----ALNWEVTLCLLAC 242

  Fly   676 WAAVFLILCKGLKSLGKLAYIIYTLPLVALAVVTAKFVYVVDPSRIQNI--FAASDFDDFLVNSN 738
            |..|:..:.||:||.||:.|...|.|.|.|.|:..:.|.:  |..:..|  :...|:.. |.:..
Human   243 WVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLL--PGALDGIIYYLKPDWSK-LGSPQ 304

  Fly   739 SWTAATQETFLTWGL-LGASVIAITSRSHTNANKAALRRDAILLVLFT-----LIGLGLMALLAL 797
            .|..|..:.|.::.: ||| :.|:.|.:..|.|   ..:|||:|.|..     ..|..:.::|..
Human   305 VWIDAGTQIFFSYAIGLGA-LTALGSYNRFNNN---CYKDAIILALINSGTSFFAGFVVFSILGF 365

  Fly   798 CCAQILWQHGYVYVPGSFENPDCYTSIYSLQSNTNPYL--LSYPRSLIPHYSSFIGETYRRNRTM 860
            ..|    :.| |::              |..:.:.|.|  ::|||::                |:
Human   366 MAA----EQG-VHI--------------SKVAESGPGLAFIAYPRAV----------------TL 395

  Fly   861 IHVESGFQALRFISEIFPAVLSLASDSISWVWAAVAFATFAGF--GLAQLCVMWKPISSALG-NS 922
            :.|...:.||.|.     .:|.|..||        .|....||  ||..|.    |.|.... ..
Human   396 MPVAPLWAALFFF-----MLLLLGLDS--------QFVGVEGFITGLLDLL----PASYYFRFQR 443

  Fly   923 TSSVLLSCVTGLLLSIPFATEMGISILYYVDFLLGGSWFIPIIWTAQIFGVFLIRGRPYNGDDLV 987
            ..||.|.|....::.:...|:.|:.:....|:.....  ..::|  |.|...::....|..|..:
Human   444 EISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASG--TTLLW--QAFWECVVVAWVYGADRFM 504

  Fly   988 NDL------RLCGSMSAFLALSWNVLLPI---GLITLSVVDYKASLSNQFYYWRGKSYFTYWSRK 1043
            :|:      |.|    .::...|:...|:   |:...:||.|:..:.|..|      .:.:|...
Human   505 DDIACMIGYRPC----PWMKWCWSFFTPLVCMGIFIFNVVYYEPLVYNNTY------VYPWWGEA 559

  Fly  1044 MGSLIQIGVLLVIPVTAIIQIYRYLAHGPPDILERIQLLYRP 1085
            ||....:..:|.:|    :.:...|......:.||.|.|.:|
Human   560 MGWAFALSSMLCVP----LHLLGCLLRAKGTMAERWQHLTQP 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bdg	NP_611064.2	SLC5-6-like_sbd	501..976	CDD:271356	123/503 (24%)
SLC6A8	NP_005620.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28
		SLC6sbd_CT1	52..621	CDD:271397	148/627 (24%)