Protein Alignment bdg and SLC6A6

DIOPT Version :9

• Sequence 1: NP_611064.2
• Gene: bdg / 36747
• FlyBaseID: FBgn0034049
• Length: 1331
• Species: Drosophila melanogaster
• Sequence 2: NP_001127839.2
• Gene: SLC6A6 / 6533
• HGNCID: 11052
• Length: 721
• Species: Homo sapiens
• Alignment Length: 827
• Identity: 172/827 - (20%)
• Similarity: 282/827 - (34%)
• Gaps: 248/827 - (29%)

  Fly   376 RQYGRRLEGPPTPVRPLILAQSRPQSAPTRVQMREPQLQDTPTHPIMSTCSELSSA--------R 432
            ||..|.:...|       |...|...|....:.|.||.|.|       :|::....        |
Human    10 RQQTREVRKKP-------LINYRFLRAAANAEPRGPQAQRT-------SCAKRECGAFTQRVRER 60

  Fly   433 SSRMPSPVSLPSDSSSSGSSSAEHDQEPDPVQTTTMCSASSTTPLEPLHQLQLL-------LREK 490
            :.|.| |......|.:.......|.:  ...:||.:..:|.|..:....:||.|       |:..
Human    61 AGRQP-PAGGTRHSRAERGRRRSHPR--SRTRTTALLRSSQTKEMATKEKLQCLKDFHKDILKPS 122

  Fly   491 CGFN----------------SQWPHAGSRTLALIGCTLGVFNMCRFAVLTI-NFGGNFLLQFLLL 538
            .|.:                .:|.......|::.|..:|:.|:.||..|.. |.||.||:.:.:.
Human   123 PGKSPGTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIF 187

  Fly   539 SVIFGIPLLWLQMCLGAKIRAGPVSMW-KISPICAGVGIALVMQQCFLALYSTVSLAWILVYLRD 602
            ....|:|:.:|::.:|.....|.::.| ||.|:.:|:|.|.|:....|.:|..|.|||...||..
Human   188 LFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQ 252

  Fly   603 VFPTA---ARSGYRWQE---MAFPYRYDAS----NATGNLTQTVAEYFNVVVLQRLHLANHPDAS 657
            .|...   |...:.|..   |....|.:.|    .::.|.|..|.|::...||......:||  .
Human   253 SFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLSLSPGIDHP--G 315

  Fly   658 GIRFHVNDRQLAFYLALIWAAVFLILCKGLKSLGKLAYIIYTLPLVALAVVTA------------ 710
            .:::     .||..|.|:|...|..:.||::|.||:.|...|.|...|.|:..
Human   316 SLKW-----DLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGI 375

  Fly   711 KFVYVVDPSRIQNIFAASDFDDFLVNSNSWTAATQETFLTWGL-LGASVIAITSRSHTNANKAAL 774
            ||....|.:|::             :...|..|..:.|.::.: ||    |:||....|..|...
Human   376 KFYLYPDITRLE-------------DPQVWIDAGTQIFFSYAICLG----AMTSLGSYNKYKYNS 423

  Fly   775 RRDAILLVLFT-----LIGLGLMALLALCCAQILWQHGYVYVPGSFENPDCYTSIYSLQSNTNPY 834
            .||.:||....     :.|..:.::|           |::......:..|.      .:|.....
Human   424 YRDCMLLGCLNSGTSFVSGFAIFSIL-----------GFMAQEQGVDIADV------AESGPGLA 471

  Fly   835 LLSYPR------------------------------------SLIPHYSSFIGETYRRNRTMIHV 863
            .::||:                                    ||:..|.||:.:.|||
Human   472 FIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRR------- 529

  Fly   864 ESGFQALRFISEIFPAVLSLASDSISWVWAAVAFATFAGFGLAQLCVMWKPISSALGNSTSSVLL 928
                       |||                 :||.
Human   530 -----------EIF-----------------IAFV------------------------------ 536

  Fly   929 SCVTGLLLSIPFATEMGISILYYVDFLLGGSWFIPIIWTAQIFGVFLIRGRPYNGDDLVNDLR-L 992
             |....||.:...||.|:.:....|:.....  :.::|.| .|..|:| ...|.||:|.:.:. :
Human   537 -CSISYLLGLTMVTEGGMYVFQLFDYYAASG--VCLLWVA-FFECFVI-AWIYGGDNLYDGIEDM 596

  Fly   993 CG-SMSAFLALSWNVLLP---IGLITLSVVDYKASLSNQFYYWRGKSYFTYWSRKMGSLIQIGVL 1053
            .| ....::..||.|:.|   :|....|:|.|.....|:.|      .:..|:..:|..:.:..:
Human   597 IGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYVPLTYNKTY------VYPNWAIGLGWSLALSSM 655

  Fly  1054 LVIPVTAIIQIYRYLAHGPPDILERIQLLYRPPE--------EGEEP 1092
            |.:|:..:|::.:  ..||  .|.|::.|..|.|        ||..|
Human   656 LCVPLVIVIRLCQ--TEGP--FLVRVKYLLTPREPNRWAVEREGATP 698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bdg	NP_611064.2	SLC5-6-like_sbd	501..976	CDD:271356	112/540 (21%)
SLC6A6	NP_001127839.2	SLC6sbd_TauT	142..683	CDD:271398	139/661 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900