DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bdg and SLC6A3

DIOPT Version :9

Sequence 1:	NP_611064.2	Gene:	bdg / 36747	FlyBaseID:	FBgn0034049	Length:	1331	Species:	Drosophila melanogaster
Sequence 2:	NP_001035.1	Gene:	SLC6A3 / 6531	HGNCID:	11049	Length:	620	Species:	Homo sapiens

Alignment Length:	721	Identity:	176/721 - (24%)
Similarity:	284/721 - (39%)	Gaps:	177/721 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   436 MPSPVSLPSDSSSSGSSSAE--HDQEPDPVQTTTMCSASSTTPLEPLHQLQLLLREKCGFNSQWP 498
            |.|.|:...:.::.|....|  ..:|.:.||.|   |::.|.|.:...:.|        ....|.
Human    11 MSSVVAPAKEPNAVGPKEVELILVKEQNGVQLT---SSTLTNPRQSPVEAQ--------DRETWG 64

  Fly   499 HAGSRTLALIGCTLGVFNMCRFAVLTI-NFGGNFLLQFLLLSVIFGIPLLWLQMCLGAKIRAGPV 562
            ......|::||..:.:.|:.||..|.. |.||.||:.:||..||.|:||.::::.||...|.|..
Human    65 KKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAA 129

  Fly   563 SMWKISPICAGVGIALVMQQCFLALYSTVSLAWILVYLRDVFPTA-----ARSGYRWQEMAFPYR 622
            .:|||.||..|||..:::...::..:..|.:||.|.||...|.|.     ..:.:.....:..:.
Human   130 GVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHP 194

  Fly   623 YDASNATGNLTQT-----VAEYFNVVVLQRLHLANHPDASG-IRFHVNDRQLAFYLALIWAAVFL 681
            .|:|..:..|..|     .||||...|| .||.::..|..| .|:     ||...|.|:...::.
Human   195 GDSSGDSSGLNDTFGTTPAAEYFERGVL-HLHQSHGIDDLGPPRW-----QLTACLVLVIVLLYF 253

  Fly   682 ILCKGLKSLGKLAYIIYTLPLVALAVVTAKFVYVVDPSRIQNIFAASDFDDF-LVNSNSW-TAAT 744
            .|.||:|:.||:.:|..|:|.|.|..:..:.|.:  |..|..|.|....|.: |..::.| .|||
Human   254 SLWKGVKTSGKVVWITATMPYVVLTALLLRGVTL--PGAIDGIRAYLSVDFYRLCEASVWIDAAT 316

  Fly   745 QETFLTWGLLGASVIAITSRSHTNANKAALRRDAILLVLFTLIGLGLMALLALCCAQILWQHGYV 809
            |                                    |.|:| |:|...|:|.        ..|
Human   317 Q------------------------------------VCFSL-GVGFGVLIAF--------SSY- 335

  Fly   810 YVPGSFENPDCY------TSIYSLQSNTNPYLLSYPRSLIPHYSSFIGETYRRNRTMI-HVESGF 867
               ..|.| :||      |||.||.|.::.:::          .||:|...:::...| .|....
Human   336 ---NKFTN-NCYRDAIVTTSINSLTSFSSGFVV----------FSFLGYMAQKHSVPIGDVAKDG 386

  Fly   868 QALRFISEIFPAVLSLASDSISWVWAAVAFATFAGFGLAQLCVMWKPISSALGNSTSSVLLSCVT 932
            ..|.||  |:|.  ::|:..:|..||.|.|......|          |.||:|.     :.|.:|
Human   387 PGLIFI--IYPE--AIATLPLSSAWAVVFFIMLLTLG----------IDSAMGG-----MESVIT 432

  Fly   933 GL-----------------------LLSIPFATEMGISILYYVDFLLGGSWFIPIIWTAQIFGVF 974
            ||                       |||:...|..||.:...:|....|        |:.:|||.
Human   433 GLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAG--------TSILFGVL 489

  Fly   975 L-------IRGRPYNGDDLVNDLRLCGSM-SAFLALSWNVLLP---IGLITLSVVDYKASLSNQF 1028
            :       ..|.....||:   .::.|.. |.:..|.|.::.|   :.::.:|:|.::..
Human   490 IEAIGVAWFYGVGQFSDDI---QQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPP----- 546

  Fly  1029 YYWRGKSYFTYWSRKMGSLIQIGVLLVIPVTAIIQIYRYLAHGPPDILERIQLLYRPPEEGEEPR 1093
            :|  |...|..|:..:|.:|....:.::|:.|   .|::.:. |....|::.....|.::.|...
Human   547 HY--GAYIFPDWANALGWVIATSSMAMVPIYA---AYKFCSL-PGSFREKLAYAIAPEKDRELVD 605

  Fly  1094 RPSARQ 1099
            |...||
Human   606 RGEVRQ 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdg	NP_611064.2	SLC5-6-like_sbd	501..976	CDD:271356	136/525 (26%)
SLC6A3	NP_001035.1	SLC6sbd_DAT1	60..614	CDD:212083	163/661 (25%)
SLC6A3	NP_001035.1	Interaction with TGFB1I1. /evidence=ECO:0000269\|PubMed:12177201	561..590		6/32 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900