DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bdg and SLC6A2

DIOPT Version :9

Sequence 1:	NP_611064.2	Gene:	bdg / 36747	FlyBaseID:	FBgn0034049	Length:	1331	Species:	Drosophila melanogaster
Sequence 2:	NP_001165975.1	Gene:	SLC6A2 / 6530	HGNCID:	11048	Length:	628	Species:	Homo sapiens

Alignment Length:	712	Identity:	159/712 - (22%)
Similarity:	265/712 - (37%)	Gaps:	179/712 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   470 SASSTTPLEPLHQLQ----LLLREKCGF-------------NSQWPHAGSRTLALIGCTLGVFNM 517
            :.:.|.|.:||...:    |:::|:.|.             ...|.......|:::|..:.:.|:
Human    15 NGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANV 79

  Fly   518 CRFAVLTI-NFGGNFLLQFLLLSVIFGIPLLWLQMCLGAKIRAGPVSMWKISPICAGVGIALVMQ 581
            .||..|.. |.||.||:.:.|..:|.|:||.::::.||...|.|..::|||.|...|||.|:::.
Human    80 WRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILI 144

  Fly   582 QCFLALYSTVSLAWILVYLRDVFPTAARSGYRWQEMAFPYRYDASNAT----------GNLTQ-- 634
            ..::..|..|.:||.|.||...|..    ...|.:..  :.:::.|.|          ||.|:
Human   145 ALYVGFYYNVIIAWSLYYLFSSFTL----NLPWTDCG--HTWNSPNCTDPKLLNGSVLGNHTKYS 203

  Fly   635 -----TVAEYFNVVVLQRLHLANHPDASGIR-FHVNDRQLAFYLALIWAAVFLILCKGLKSLGKL 693
                 ..||::...|| .||     ::|||. ..:...||...|.::...::..|.||:|:.||:
Human   204 KYKFTPAAEFYERGVL-HLH-----ESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKV 262

  Fly   694 AYIIYTLPLVALAVVTAKFVYVVDPSRIQNIFAASDFDDFLVNSNSWTAATQETFLTWGLLGASV 758
            .:|..|||...|.|:....|.:...|...|.:...||.. |..:..|..|..:.|.:.|.....:
Human   263 VWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYR-LKEATVWIDAATQIFFSLGAGFGVL 326

  Fly   759 IAITSRSHTNANKAALRRDAILLVLFTLIGLGLMALLALCCAQILWQHGYVYVPGSFENPDCYTS 823
            ||..|.:..:.|   ..|||:|.                                  .:.:|.||
Human   327 IAFASYNKFDNN---CYRDALLT----------------------------------SSINCITS 354

  Fly   824 IYSLQSNTNPYLLSYPRSLIPHYSSFIGETYRRNRTMIHVES-GFQALRFISEIFPAVLSLASDS 887
            ..|                  .::.|....|..:...:::|. ..:....:..::|..:|..|.|
Human   355 FVS------------------GFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGS 401

  Fly   888 ISWVWAAVAFATFAGFGLAQLCVMWKPISSALGN------------------STSSVLLSCVTG- 933
            .  .||.|.|......||.......:.:.:.|.:                  ||..:.|.|:|.
Human   402 T--FWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKG 464

  Fly   934 ----LLLSIPFATEMGISILYYVDF-LLGGSWFIPIIWTAQIFGVFLIRGRPYNGDDLVNDLRLC 993
                |.|...||.  |.|||:.|.. .:|.|||                   |..|...||::
Human   465 GIYVLTLLDTFAA--GTSILFAVLMEAIGVSWF-------------------YGVDRFSNDIQ-- 506

  Fly   994 GSMSAF-----LALSWNVLLP---IGLITLSVVDYKASLSNQFYYWRGKSYFTYWSRKMGSLIQI 1050
             .|..|     ..|.|..:.|   :.::.:|::::|....:.:       .|..|:..:|..|.:
Human   507 -QMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDY-------IFPPWANWVGWGIAL 563

  Fly  1051 GVLLVIPVTAIIQIYRYLA-HGPPDILERIQLLYRPPEEGEEPRRPSARQ---TASQSRRNA 1108
            ..::::|   |..||::|: .|  .:.||:.....|..|.....:...||   ...|.||.|
Human   564 SSMVLVP---IYVIYKFLSTQG--SLWERLAYGITPENEHHLVAQRDIRQFQMKTRQGRRRA 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdg	NP_611064.2	SLC5-6-like_sbd	501..976	CDD:271356	120/518 (23%)
SLC6A2	NP_001165975.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		2/7 (29%)
SLC6A2	NP_001165975.1	SLC6sbd_NET	56..612	CDD:212081	148/661 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900