DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bdg and SLC6A20

DIOPT Version :9

Sequence 1:	NP_611064.2	Gene:	bdg / 36747	FlyBaseID:	FBgn0034049	Length:	1331	Species:	Drosophila melanogaster
Sequence 2:	NP_001372612.1	Gene:	SLC6A20 / 54716	HGNCID:	30927	Length:	603	Species:	Homo sapiens

Alignment Length:	677	Identity:	145/677 - (21%)
Similarity:	268/677 - (39%)	Gaps:	183/677 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   497 WPHAGSRTLALIGCTLGVFNMCRFAVLTINF-GGNFLLQFLLLSVIFGIPLLWLQMCLGAKIRAG 560
            |.::.....|.|...:|:.|:.||..|...: ||:||:.::::.::.|:|||:|::.:|.::|.|
Human     8 WANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQRMRQG 72

  Fly   561 PVSMWK-ISPICAGVGIALVMQQCFLALYSTVSLAWILVYL----RDVFPTAA------RSGYRW 614
            .:..|: |||..:|||:|.|:...||::|..|..||...||    :|..|.:.      .:||..
Human    73 SIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVCPLNGNHTGYDE 137

  Fly   615 Q-EMAFPYRYDASNATGNLTQTVAEYFNVVVLQRLHLANHPDASGIRFHVNDRQLAFYLALIWAA 678
            : |.|...:|.....|.|::.::.|                 ..|:::     :.|..|.|.|..
Human   138 ECEKASSTQYFWYRKTLNISPSLQE-----------------NGGVQW-----EPALCLLLAWLV 180

  Fly   679 VFLILCKGLKSLGKLAYIIYTLPLVALAV----------VTAKFVYVVDPSRIQNIFAASDFDDF 733
            |:|.:.:|.:|.||:.|...:||...|.:          .|...:|:..|.....:...:...:.
Human   181 VYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKGSSALSLLAFQIEQ 245

  Fly   734 LVNSNSWTAATQETFLTWGLLGASVIAITSRSHTNANKAALRRDAILLVL---FTLIGLGLMALL 795
            |.|..:|..|..:.|.:.||...|:||..|.:..:.|   .::.||::.|   ||.|...::...
Human   246 LANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNN---CQKHAIIVSLINSFTSIFASIVTFS 307

  Fly   796 ALCCAQILWQHGYVYVPGSFENPDCYTSIYSLQSNT----NPYLLSYPRSLIPHYSSFIGETYRR 856
            .         :|:   ..:|...:|...:..|.:||    :.:|.:   |.:.....::...|..
Human   308 I---------YGF---KATFNYENCLKKVSLLLTNTFDLEDGFLTA---SNLEQVKGYLASAYPS 357

  Fly   857 NRTMIHVESGFQALRFISEIFPAVLSLASDS------------------------ISWVWAAVAF 897
            .               .||:||.:.:.:.:|                        :|.:|:.:.|
Human   358 K---------------YSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYF 407

  Fly   898 ATFAGFGLAQLCVMWKPISSALGNS-------TSSVLLS------CVTGLLLSIPFATEMGISIL 949
            ......|          |.|.|||:       |.|.::|      .::||:..:..|    |.::
Human   408 FMLLMLG----------IGSMLGNTAAILTPLTDSKIISSHLPKEAISGLVCLVNCA----IGMV 458

  Fly   950 YYVDFLLGGSWF--------------IPIIWTAQIFGVFLIRGRPYNGDDLVNDLR-LCG-SMSA 998
            :.::  .|..||              |.::.|..:..|:.:|       ...:||: :.| ::|.
Human   459 FTME--AGNYWFDIFNDYAATLSLLLIVLVETIAVCYVYGLR-------RFESDLKAMTGRAVSW 514

  Fly   999 FLALSWNVLLPIGLITLSVVDYKASLSNQFYYWRGKSYFTYWSRKMGSLIQ----------IGVL 1053
            :..:.|..:.|:.:::|.|.    .||:  |...|...:..|....|.|:.          ||:|
Human   515 YWKVMWAGVSPLLIVSLFVF----YLSD--YILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLL 573

  Fly  1054 -----LVIPVTAI-IQIYRYLAHGPPD 1074
                 :.||:.|: ..:.|.|..|..|
Human   574 VASSTMCIPLAALGTFVQRRLKRGDAD 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdg	NP_611064.2	SLC5-6-like_sbd	501..976	CDD:271356	118/555 (21%)
SLC6A20	NP_001372612.1	SLC6sbd_SIT1	2..588	CDD:271401	141/663 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900