DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bdg and Slc6a16

DIOPT Version :9

Sequence 1:	NP_611064.2	Gene:	bdg / 36747	FlyBaseID:	FBgn0034049	Length:	1331	Species:	Drosophila melanogaster
Sequence 2:	NP_001311464.1	Gene:	Slc6a16 / 381884	MGIID:	2685930	Length:	742	Species:	Mus musculus

Alignment Length:	785	Identity:	179/785 - (22%)
Similarity:	298/785 - (37%)	Gaps:	204/785 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   383 EGPPTPVRPLILAQSRPQSAPTRVQMREPQLQDTPTHPIMSTCSELSSARSSRMPSPVSLPSDSS 447
            ||...|        |:.:::|:.|    ||..::.....:|..|:|:...|......|.:.:.|.
Mouse     6 EGENEP--------SKSRASPSDV----PQASESNMEESVSWDSKLTDMDSHLGAWEVGMLTWSP 58

  Fly   448 SSGSSSAEHDQ-------------------EPDPVQTTTMCSASSTTPLEPLHQLQLLLREKC-G 492
            |:..:.|:..:                   :|.|  :.|..:..:|...|....:..:.||.. |
Mouse    59 STWIAQAQVSETRMAKAQAWETLALARITLQPKP--SVTELATVTTLEQESSELVNRMSRESSEG 121

  Fly   493 F--NSQWPHAGSRTLALIGCTLGVFNMCRFAVLTINFGG-NFLLQFLLLSVIFGIPLLWLQMCLG 554
            :  ...|.......||::...|....:.|||...::.|. :|.:.::|:.:..|||||:|:|.:|
Mouse   122 YPPRQLWASKVEYMLAIMSYLLMPSGVLRFASGWVHKGSCSFFIAYILMLLGIGIPLLFLEMAVG 186

  Fly   555 AKIRAGPVSMWK-ISPICAGVGIALVMQQCFLA-LYSTVSLAWILVYLRDVF----PTAARSGYR 613
            .:.:.....||| :||...|||.::|| .||:. .|..|..:|||.|:..:|    |
Mouse   187 QRAQQSSADMWKNLSPWFGGVGYSMVM-VCFITNTYLNVFNSWILFYMSHIFYFVVP-------- 242

  Fly   614 WQEMAFPYRYDASNATGNLTQ-TVAEYF----NVVVLQRLHLANHPDASGIRFHVNDRQLAFYLA 673
            |.:.  |.:.::||......| |...||    .:....|:.....|..|          |...|.
Mouse   243 WDQC--PLQRNSSNFDPECEQATSYTYFWYRKTLKASDRIEDGGQPSFS----------LGMSLF 295

  Fly   674 LIWAAVFLILCKGLKSLGKLAYIIYTLP---LVALAVVTAKF---VYVVDPSRIQNIFAASDFDD 732
            |.:..:...|..|:||:||:.:::..:|   :|...:.|...   .|.:....|..:.:.||.
Mouse   296 LSFCLICAFLVNGIKSIGKVLFVLLLVPYSIIVCFLIRTLSMDGAEYGLKHLLILKVASISDL-- 358

  Fly   733 FLVNSNSWTAATQETFLTWGLLGASVIAITSRSHTNANKAALRRDAILLVLFTLIGL-----GLM 792
                 ..|..|..:.....||....::::.|......|..|   ||.|:.||.:|.|     .|:
Mouse   359 -----TIWCHAGIQVLFDIGLGFGPIVSLASHVPDFNNCMA---DAFLMALFKIITLLMTTPFLL 415

  Fly   793 ALLAL--------CCAQ----ILWQHGYVYVPGSFENPDCY---TSIY-SLQSNTNPYLLSYPRS 841
            ::|..        ||.:    :|.......:|...:.||..   ||.| |..|:..|.|.|...|
Mouse   416 SILGFWATTTTHHCCKKNQETLLRLVAQGILPPDAQPPDLSGNPTSNYNSWLSSLPPPLRSAVLS 480

  Fly   842 LIPHYSSFIGETYRRNRTMIHVESGFQAL----RFISEIFPAVLSLASDSISWVWAAVAFATFAG 902
            ::|..|               |:..|..:    ||:..||..|:||...|..|:  .:.|.....
Mouse   481 VVPECS---------------VQKQFLKIKDNPRFLFLIFTEVISLLPGSGFWI--VLFFLLLLT 528

  Fly   903 FGL-AQLCVMWKPISSALGNSTS------------SVLLSCVT------GLLLSIPFATEMGISI 948
            .|| :.|..|       |||..:            .:|:.||:      ||:...|       |.
Mouse   529 LGLCSNLMFM-------LGNVLTLQDTFPFCRRQPRLLIVCVSMAMFLCGLIFIQP-------SG 579

  Fly   949 LYYVDFLLGGSWF-IPII-----------WTAQIFGV--FL-----IRGRP-YNGDDLVNDLRLC 993
            :||.. ||...|. :|:|           |.   :|.  ||     :.||| ::|         |
Mouse   580 IYYFS-LLSECWVAVPVIIIIICENLAVAWA---YGADRFLADMVALLGRPIFSG---------C 631

  Fly   994 GSMSAFLALSWNVLLPIGLITLSVVDYKASLSNQFYYWRGKS------YFTYWSRKMGSLIQIGV 1052
            |.:..::    :.::.:||:| ||..|.......::.|...:      .|..||:.:.:.:.:.|
Mouse   632 GWLWCYI----SPMVVLGLLT-SVFVYLVKGPLVYFAWDSSTSKEVVRVFPEWSKILIAGLTVFV 691

  Fly  1053 LLVIP 1057
            |:.||
Mouse   692 LMPIP 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdg	NP_611064.2	SLC5-6-like_sbd	501..976	CDD:271356	134/555 (24%)
Slc6a16	NP_001311464.1	SLC5-6-like_sbd	125..694	CDD:294310	153/648 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000