DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bdg and Slc6a6

DIOPT Version :9

Sequence 1:	NP_611064.2	Gene:	bdg / 36747	FlyBaseID:	FBgn0034049	Length:	1331	Species:	Drosophila melanogaster
Sequence 2:	XP_030111163.1	Gene:	Slc6a6 / 21366	MGIID:	98488	Length:	631	Species:	Mus musculus

Alignment Length:	761	Identity:	168/761 - (22%)
Similarity:	262/761 - (34%)	Gaps:	247/761 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   416 TPTHP---IMSTCSELSSARSSRMPSPVSLPSDSSSSGSSSAEHDQEPDPVQTTTMCSASSTTPL 477
            ||.||   .|:|..:|...:.  ....:..||...|.| :..|.:.:..|.|
Mouse     2 TPVHPENEEMATKEKLQCLKD--FHKDILKPSPGKSPG-TRPEDEADGKPPQ------------- 50

  Fly   478 EPLHQLQLLLREKCGFNSQWPHAGSRTLALIGCTLGVFNMCRFAVLTI-NFGGNFLLQFLLLSVI 541
                      |||      |.......|::.|..:|:.|:.||..|.. |.||.||:.:.:....
Mouse    51 ----------REK------WSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFG 99

  Fly   542 FGIPLLWLQMCLGAKIRAGPVSMW-KISPICAGVGIALVMQQCFLALYSTVSLAWILVYLRDVFP 605
            .|:|:.:|::.:|.....|.::.| ||.|:.:|:|.|.::....|.:|..|.|||...||...|.
Mouse   100 SGLPVFFLEVIIGQYTSEGGITCWEKICPLFSGIGYASIVIVSLLNVYYIVILAWATYYLFHSFQ 164

  Fly   606 TA---ARSGYRW---QEMAFPYRYDASN----ATGNLTQTVAEYF--NVVVLQRLHLANHPDASG 658
            ..   |...:.|   |.|....|.:.|:    :|.|.|..|.|::  ||:.|          :||
Mouse   165 KDLPWAHCNHSWNTPQCMEDTLRRNESHWVSLSTANFTSPVIEFWERNVLSL----------SSG 219

  Fly   659 IRFHVNDR------QLAFYLALIWAAVFLILCKGLKSLGKLAYIIYTLPLVALAVVTA------- 710
            |     |.      .||..|.|:|...|..:.||::|.||:.|...|.|...|.|:..
Mouse   220 I-----DNPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPG 279

  Fly   711 -----KFVYVVDPSRIQNIFAASDFDDFLVNSNSWTAATQETFLTWGL-LGASVIAITSRSHTNA 769
                 ||....|.||             |.:...|..|..:.|.::.: ||    |:||....|.
Mouse   280 AGEGIKFYLYPDISR-------------LGDPQVWIDAGTQIFFSYAICLG----AMTSLGSYNK 327

  Fly   770 NKAALRRDAILLVLFT-----LIGLGLMALLALCCAQILWQHGYVYVPGSFENPDCYTSIYSLQS 829
            .|....||.:||....     :.|..:.::|           |::......:..|.      .:|
Mouse   328 YKYNSYRDCMLLGCLNSGTSFVSGFAIFSIL-----------GFMAQEQGVDIADV------AES 375

  Fly   830 NTNPYLLSYPR------------------------------------SLIPHYSSFIGETYRRNR 858
            ......::||:                                    ||:..|.||:.:.|||
Mouse   376 GPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRR-- 438

  Fly   859 TMIHVESGFQALRFISEIFPAVLSLASDSISWVWAAVAFATFAGFGLAQLCVMWKPISSALGNST 923
                            |||.|:|
Mouse   439 ----------------EIFIAIL------------------------------------------ 445

  Fly   924 SSVLLSCVTGLLLSIPFATEMGISILYYVDFLLGGSWFIPIIWTAQIFGVFLIRGRPYNGDDLVN 988
                  |....||.:...||.|:.:....|:.....  :.::|.| .|..|:| ...|.||:|.:
Mouse   446 ------CSISYLLGLTMVTEGGMYVFQLFDYYAASG--VCLLWVA-FFECFVI-AWIYGGDNLYD 500

  Fly   989 DLR-LCG-SMSAFLALSWNVLLP---IGLITLSVVDYKASLSNQFYYWRGKSYFTYWSRKMGSLI 1048
            .:. :.| ....::..||.|:.|   :|....|:|.|.....|:.|      .:..|:..:|..:
Mouse   501 GIEDMIGYRPGPWMKYSWAVITPALCVGCFVFSLVKYVPLTYNKVY------RYPDWAIGLGWGL 559

  Fly  1049 QIGVLLVIPVTAIIQIYRYLAHGPPDILERIQLLYRPPEEGEEPRR 1094
            .:..:|.||:..:|.:.|  ..||  :..||:.|..|    .||.|
Mouse   560 ALSSMLCIPLVIVILLCR--TEGP--LRVRIKYLITP----REPNR 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdg	NP_611064.2	SLC5-6-like_sbd	501..976	CDD:271356	118/548 (22%)
Slc6a6	XP_030111163.1	SLC5-6-like_sbd	51..592	CDD:382020	150/675 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900