DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bdg and Slc6a2

DIOPT Version :9

Sequence 1:	NP_611064.2	Gene:	bdg / 36747	FlyBaseID:	FBgn0034049	Length:	1331	Species:	Drosophila melanogaster
Sequence 2:	NP_033235.3	Gene:	Slc6a2 / 20538	MGIID:	1270850	Length:	617	Species:	Mus musculus

Alignment Length:	691	Identity:	157/691 - (22%)
Similarity:	269/691 - (38%)	Gaps:	150/691 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   459 EPDPVQTTTMCSASSTTPLEPLHQLQLLL---------REKCGFNSQWPHAGSRTLALIGCTLGV 514
            :|.|.|....|..:....::..:.:|.||         ||      .|.......|:::|..:.:
Mouse    18 DPLPEQPLRPCKTADLLVVKERNGVQCLLASQDSDAQPRE------TWGKKIDFLLSVVGFAVDL 76

  Fly   515 FNMCRFAVLTI-NFGGNFLLQFLLLSVIFGIPLLWLQMCLGAKIRAGPVSMWKISPICAGVGIAL 578
            .|:.||..|.. |.||.||:.:.|..:|.|:||.::::.||...|.|..::|||.|...|||.|:
Mouse    77 ANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAV 141

  Fly   579 VMQQCFLALYSTVSLAWILVYLRDVFPTA---ARSGYRWQ--EMAFPYRYDASNATGNLTQ---- 634
            ::...::..|..|.:||.|.||...|...   ...|:.|.  ....|...:|| ..|:.|:
Mouse   142 ILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHSWNSPNCTDPKLLNAS-VLGDHTKYSKY 205

  Fly   635 ---TVAEYFNVVVLQRLHLANHPDASGIR-FHVNDRQLAFYLALIWAAVFLILCKGLKSLGKLAY 695
               ..||::...|| .||     ::|||. ..:...||...|.::...::..|.||:|:.||:.:
Mouse   206 KFTPAAEFYERGVL-HLH-----ESSGIHDIGLPQWQLLLCLMVVIVVLYFSLWKGVKTSGKVVW 264

  Fly   696 IIYTLPLVALAVVTAKFVYVVDPSRIQNIFAASDFDDFLVNSNSW-TAATQETFLTWGLLGASVI 759
            |..|||...|.|:....|.:...|...|.:...||.. |..:..| .||||
Mouse   265 ITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYR-LKEATVWIDAATQ-------------- 314

  Fly   760 AITSRSHTNANKAALRRDAILLVLFTLIGLGLMALLALCCAQILWQHGYVYVPGSFENPDCYTSI 824
                                   :|..:|.|...|:|..        .|    ..|:| :||..
Mouse   315 -----------------------IFFSLGAGFGVLIAFA--------SY----NKFDN-NCYRD- 342

  Fly   825 YSLQSNTNPYLLSYPRSLIPHYSSFIGETYRRNRTMIHVES-GFQALRFISEIFPAVLSLASDSI 888
             :|.::|    ::...|.|..::.|....|..:...:::|. ..:....:..::|..:|..|.|.
Mouse   343 -ALLTST----INCVTSFISGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGST 402

  Fly   889 SWVWAAVAFATFAGFGLAQLCVMWKPISSALGNSTSSV---------------LLSCVTGL---L 935
              .||.:.|......||          .|::|...:.:               |.:||..:   |
Mouse   403 --FWAVLFFLMLLALGL----------DSSMGGMEAVITGLADDFQVLKRHRKLFTCVVTISTFL 455

  Fly   936 LSIPFATEMGISILYYVD-FLLGGSWFIPIIWTAQIFGVFLIRGRPYNGDDLVNDL-RLCG-SMS 997
            |::...|:.||.:|..:| |..|.|....::..|  .||...    |..|...||: ::.| ...
Mouse   456 LALFCITKGGIYVLTLLDTFAAGTSILFAVLMEA--IGVSWF----YGVDRFSNDIQQMMGFKPG 514

  Fly   998 AFLALSWNVLLP---IGLITLSVVDYKASLSNQFYYWRGKSYFTYWSRKMGSLIQIGVLLVIPVT 1059
            .:..|.|..:.|   :.::.:|::::|....:.:.|       ..|:..:|..|.:..::::|..
Mouse   515 LYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYTY-------PPWANWVGWGIALSSMILVPAY 572

  Fly  1060 AIIQIYRYLA-HGPPDILERIQLLYRPPEEGEEPRRPSARQ 1099
            .   ||::|: .|  .:.||:.....|..|.....:...||
Mouse   573 V---IYKFLSIRG--SLWERVAYGITPENEHHLVAQRDVRQ 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdg	NP_611064.2	SLC5-6-like_sbd	501..976	CDD:271356	122/509 (24%)
Slc6a2	NP_033235.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		1/2 (50%)
Slc6a2	NP_033235.3	SLC5-6-like_sbd	56..615	CDD:382020	150/653 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900