DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bdg and Slc6a5

DIOPT Version :9

Sequence 1:	NP_611064.2	Gene:	bdg / 36747	FlyBaseID:	FBgn0034049	Length:	1331	Species:	Drosophila melanogaster
Sequence 2:	NP_976079.1	Gene:	Slc6a5 / 171148	RGDID:	621824	Length:	799	Species:	Rattus norvegicus

Alignment Length:	921	Identity:	193/921 - (20%)
Similarity:	330/921 - (35%)	Gaps:	280/921 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   338 DCQA----SVAPTVGSQMLTEAHIFDNLLQTNARASSEEPR-PR---QYGRRLEGPPTPVRPLIL 394
            ||.|    :..||             |:|:.......:.|| ||   :.......|...|:|..:
  Rat     2 DCSAPKEMNKPPT-------------NILEATVPGHRDSPRAPRTSPEQDLPAAAPAAAVQPPRV 53

  Fly   395 AQSRP------QSAPTRV-----------QMREPQLQDTPTHPIMSTCSELSSARSSRMPSP--- 439
            .:|..      |||..|.           ::..||.|.|     .:...:||...|::...|
  Rat    54 PRSASTGAQTFQSADARACEAQRPGVGFCKLSSPQAQAT-----SAALRDLSEGHSAQANPPSGA 113

  Fly   440 --------VSLPS-------DSSSSGSSSAEHDQEPDPV------QTTTMCS------------A 471
                    ..:|:       ::.|....:.||:..| ||      |:|.:..            |
  Rat   114 AGAGNALHCKIPALRGPEEDENVSVAKGTLEHNNTP-PVGWVNMSQSTVVLGTDGIASVLPGSVA 177

  Fly   472 SSTTPLEPLHQLQLLLREKCGFN---SQWPHAGSRTLALIGCTLGVFNMCRFAVLTI-NFGGNFL 532
            ::|.|.:          |:...|   ..|.......|:::|..:|:.|:.||..|.. |.||.||
  Rat   178 TTTIPED----------EQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFL 232

  Fly   533 LQFLLLSVIFGIPLLWLQMCLGAKIRAGPVSMWKISPICAGVGIALVMQQCFLALYSTVSLAWIL 597
            :.:|::..:.|:|:.:|::.||.....||||:||..|...|.|||:::....:|:|..|.:.:.|
  Rat   233 IPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTL 297

  Fly   598 VYLRDVFPTAARSGYRWQEMAFPY----------------------RYDASNAT------GNLTQ 634
            .||...|.    |...|.....|:                      :....|:|      .|||.
  Rat   298 FYLFASFV----SVLPWGSCNNPWNTPECKDKTKLLLDSCVIGDHPKIQIKNSTFCMTAYPNLTM 358

  Fly   635 T-------------VAEYFNVVVLQRLHLANHPDASGIRFHVNDR-QLAFYLALIWAAVFLILCK 685
            .             ..|||...||:        .::||.:....| .|.|.|.|.|..|:..|.|
  Rat   359 VNFTSQANKTFVSGSEEYFKYFVLK--------ISAGIEYPGEIRWPLPFCLFLAWVIVYASLAK 415

  Fly   686 GLKSLGKLAYIIYTLPLVALAVVTAKFV----------YVVDPSRIQNIFAASDFDDFLVNSNSW 740
            |:|:.||:.|...|.|.|.|.::..:.|          |.:.|..           :.|.::..|
  Rat   416 GIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKW-----------EKLTDATVW 469

  Fly   741 TAATQETFLT----WGLLGASVIAITSRSHTNANKAALRRDAILLVLFTLIGLGLMALLALCCAQ 801
            ..|..:.|.:    ||  |...::..::.|.|.     .||. |:|..|.....:.|
  Rat   470 KDAATQIFFSLSAAWG--GLITLSSYNKFHNNC-----YRDT-LIVTCTNSATSIFA-------- 518

  Fly   802 ILWQHGYVYVPGSFENPDCYTSIYSLQSNTNPYLLSYPRSLIPHYSSFIGETYRRNRTMIHVESG 866
                 |:|              |:|:                      ||  :..|...:::|:.
  Rat   519 -----GFV--------------IFSV----------------------IG--FMANERKVNIENV 540

  Fly   867 FQ---ALRFISEIFPAVLSLASDSISWVWAAVAFATFAGFGLAQLCVMWKPISSALGNSTSSVLL 928
            ..   .:.|:  ::|..|:..  .:|..||.:.|......||..:....:.|.:::.:.....|.
  Rat   541 ADQGPGIAFV--VYPEALTRL--PLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLR 601

  Fly   929 S---------CVTGLLLSIPFATEMGISILYYVDFLLGGSWFIPIIWTAQIFGVFLIRGRPYNGD 984
            :         |:...::..|..|:.||.:...|| ....|:.:.||...::.|:..:.|..
  Rat   602 THKPVFTLGCCICFFIMGFPMITQGGIYMFQLVD-TYAASYALVIIAIFELVGISYVYGLQ---- 661

  Fly   985 DLVNDLRLCGSMSAFLALSWNVLLPI--GLITLSVVDYKASLSNQFYYWRGKSYFTY----WSRK 1043
                  |.|..:...:....|:...:  ..:|.:::.:....|  ||.|...:|.:|    ||..
  Rat   662 ------RFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFS--FYQWEPMTYGSYRYPNWSMV 718

  Fly  1044 MGSLIQIGVLLVIPVTAIIQIYRYLAHGPPDILERIQLLYRP-PEEGEEPRRPSARQTASQSRRN 1107
            :|.|:....::.||:..:|::  |||  |...:||::|:..| |:.|     |...|...:..:|
  Rat   719 LGWLMLACSVIWIPIMFVIKM--YLA--PGRFIERLKLVCSPQPDWG-----PFLAQHRGERYKN 774

  Fly  1108 ---ALGQTTEG 1115
               .||.::.|
  Rat   775 MIDPLGTSSLG 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bdg	NP_611064.2	SLC5-6-like_sbd	501..976	CDD:271356	117/543 (22%)
Slc6a5	NP_976079.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64		15/74 (20%)
Slc6a5	NP_976079.1	SLC6sbd_GlyT2	193..789	CDD:271389	152/701 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900