Protein Alignment bdg and Slc6a4

DIOPT Version :10

• Sequence 1: NP_611064.2
• Gene: bdg / 36747
• FlyBaseID: FBgn0034049
• Length: 1331
• Species: Drosophila melanogaster
• Sequence 2: NP_034614.2
• Gene: Slc6a4 / 15567
• MGIID: 96285
• Length: 630
• Species: Mus musculus
• Alignment Length: 740
• Identity: 162/740 - (21%)
• Similarity: 280/740 - (37%)
• Gaps: 179/740 - (24%)

  Fly   413 LQDTP--THPIMSTCSELSSARSSR-MPSPVSLPSDSSSSGSSSAEHDQEP-----DPVQTTTMC 469
            ::.||  :..::|.|.:....:.:. :...|..|:|.:..|..|..:...|     |....:|
Mouse     1 METTPLNSQKVLSECKDKEDCQENGVLQKGVPTPADKAGPGQISNGYSAVPSTSAGDEAPHST-- 63

  Fly   470 SASSTTPLEPLHQLQLLLREKCGFNSQWPHAGSRTLALIGCTLGVFNMCRFAVLTI-NFGGNFLL 533
            .|::||.:..:||         |....|.......|::||..:.:.|:.||..:.. |.||.|||
Mouse    64 PAATTTLVAEIHQ---------GERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLL 119

  Fly   534 QFLLLSVIFGIPLLWLQMCLGAKIRAGPVSMW-KISPICAGVGIALVMQQCFLALYSTVSLAWIL 597
            .:.::::..||||.::::.||...|.|.:|:| ||.||..|:|.|:.:...::|.|....:||.|
Mouse   120 PYTIMAIFGGIPLFYMELALGQYHRNGCISIWKKICPIFKGIGYAICIIAFYIASYYNTIIAWAL 184

  Fly   598 VYL----RDVFP-TAARSGYRWQEMAFPYRYDASNATGNLTQTVAEYFNVVVLQRLHLANHPDAS 657
            .||    .|..| |:.::.:........:..|....|.:.|....|::...|||........|..
Mouse   185 YYLISSFTDQLPWTSCKNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIHQSKGLQDLG 249

  Fly   658 GIRFHVNDRQLAFYLALIWAAVFLILCKGLKSLGKLAYIIYTLPLVALAVVTAK----------F 712
            .|.:     |||..:.||:..::..:.||:|:.||:.::..|.|.:.|:|:..:          .
Mouse   250 TISW-----QLALCIMLIFTIIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGV 309

  Fly   713 VYVVDPSRIQNIFAASDFDDFLVNSNSWTAATQETFLTWGLLGASVIAITSRSHTNANKAALRRD 777
            |:.:.|:..:           |:.:..|..|..:.|.:.|.....::|..|.:..|.|   ..:|
Mouse   310 VFYLKPNWQK-----------LLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNN---CYQD 360

  Fly   778 AIL-------------LVLFTLIGLGLMALLALCCAQILWQHGYVYVPGSFENPDCYTSIYSLQS 829
            |::             .|:||:  ||.||                    ...|.|    :..:..
Mouse   361 ALVTSVVNCMTSFVSGFVIFTV--LGYMA--------------------EMRNED----VSEVAK 399

  Fly   830 NTNPYLL--SYPRSL--IPHYSSFIGETYRRNRTMIHVESGFQALRFISEIFPAVLSLASDSISW 890
            :..|.||  :|..::  :| .|:|....:......:.::|.|..|.       .|::...|....
Mouse   400 DAGPSLLFITYAEAIANMP-ASTFFAIIFFLMLITLGLDSTFAGLE-------GVITAVLDEFPH 456

  Fly   891 VWA-------AVAFATFAGFGLAQLCVMWKPISSALGNSTSSVLL-SCVTG-LLLSIPFATEMGI 946
            :||       .:...|         |::...::...|.:....|| ...|| .:|::.....:.:
Mouse   457 IWAKRREWFVLIVVIT---------CILGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVVV 512

  Fly   947 SILY-------YVDFLLGGS--WFIPIIWTAQIFGVFLIRGRPYNGDDLVNDLRLCGSMSAFLAL 1002
            |..|       .|..:||.|  ||..|.|.| |..:||:                      |:..
Mouse   513 SWFYGITQFCSDVKEMLGFSPGWFWRICWVA-ISPLFLL----------------------FIIC 554

  Fly  1003 SWNVLLPIGLITLSVVDYKASLSNQFYYWRGKSYFTYWSRKMGSLIQIGVLLVIPVTAIIQIYRY 1067
            |:.:..|    .|.:..|.               :.:||..:|..|....::.||   |..|||
Mouse   555 SFLMSPP----QLRLFQYN---------------YPHWSIILGYCIGTSSVICIP---IYIIYR- 596

  Fly  1068 LAHGPPDILERIQLLYRPPEEGEEP 1092
            |...|..:.|||.....|....|.|
Mouse   597 LISTPGTLKERIIKSITPETPTEIP 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bdg	NP_611064.2	SLC5-6-like_sbd	501..976	CDD:271356	119/526 (23%)
Slc6a4	NP_034614.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..63		11/61 (18%)
		5HT_transport_N	24..64	CDD:397524	8/41 (20%)
		SLC6sbd_SERT	79..615	CDD:271399	141/643 (22%)
		Interaction with RAB4A. /evidence=ECO:0000250	616..624		2/6 (33%)