Protein Alignment bdg and Slc6a3

DIOPT Version :10

• Sequence 1: NP_611064.2
• Gene: bdg / 36747
• FlyBaseID: FBgn0034049
• Length: 1331
• Species: Drosophila melanogaster
• Sequence 2: NP_034150.1
• Gene: Slc6a3 / 13162
• MGIID: 94862
• Length: 619
• Species: Mus musculus
• Alignment Length: 723
• Identity: 176/723 - (24%)
• Similarity: 284/723 - (39%)
• Gaps: 182/723 - (25%)

  Fly   436 MPSPVSLPSDSSSSGSSSAE--HDQEPDPVQTTTMCSASSTTPLEPLHQLQLLLREKCGFNSQWP 498
            |.|.|:...:.::.|....|  ..:|.:.||.|     :||....|...:::..||      .|.
Mouse    11 MSSVVAPAKEPNAVGPREVELILVKEQNGVQLT-----NSTLINPPQTPVEVQERE------TWS 64

  Fly   499 HAGSRTLALIGCTLGVFNMCRFAVLTI-NFGGNFLLQFLLLSVIFGIPLLWLQMCLGAKIRAGPV 562
            ......|::||..:.:.|:.||..|.. |.||.||:.:||..||.|:||.::::.||...|.|..
Mouse    65 KKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAA 129

  Fly   563 SMWKISPICAGVGIALVMQQCFLALYSTVSLAWILVYLRDVFPTA---ARSGYRWQEMAFPYRYD 624
            .:|||.|:..|||..:::...::..:..|.:||.|.|....|...   ......|..   |...|
Mouse   130 GVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNS---PNCSD 191

  Fly   625 A--SNATGNL-------TQTVAEYFNVVVLQRLHLANHPDASG-IRFHVNDRQLAFYLALIWAAV 679
            |  ||::..|       |...||||...|| .||.:...|..| .|:     ||...|.|:...:
Mouse   192 AHSSNSSDGLGLNDTFGTTPAAEYFERGVL-HLHQSRGIDDLGPPRW-----QLTACLVLVIVLL 250

  Fly   680 FLILCKGLKSLGKLAYIIYTLPLVALAVVTAKFVYVVDPSRIQNIFAASDFDDF-LVNSNSW-TA 742
            :..|.||:|:.||:.:|..|:|.|.|..:..:.|.:  |..:..|.|....|.: |..::.| .|
Mouse   251 YFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTL--PGAMDGIRAYLSVDFYRLCEASVWIDA 313

  Fly   743 ATQETFLTWGLLGASVIAITSRSHTNANKAALRRDAILLVLFTLIGLGLMALLALCCAQILWQHG 807
            |||                                    |.|:| |:|...|:|.        ..
Mouse   314 ATQ------------------------------------VCFSL-GVGFGVLIAF--------SS 333

  Fly   808 YVYVPGSFENPDCY------TSIYSLQSNTNPYLLSYPRSLIPHYSSFIGETYRRNRTMIH-VES 865
            |    ..|.| :||      |||.||.|.::.:::          .||:|...:::...|. |.:
Mouse   334 Y----NKFTN-NCYRDAIITTSINSLTSFSSGFVV----------FSFLGYMAQKHNVPIRDVAT 383

  Fly   866 GFQALRFISEIFPAVLSLASDSISWVWAAVAFATFAGFGLAQLCVMWKPISSALGNSTSSVLLSC 930
            ....|.||  |:|.  ::|:..:|..||||.|......|          |.||:|.     :.|.
Mouse   384 DGPGLIFI--IYPE--AIATLPLSSAWAAVFFLMLLTLG----------IDSAMGG-----MESV 429

  Fly   931 VTGL-----------------------LLSIPFATEMGISILYYVDFLLGGSWFIPIIWTAQIFG 972
            :|||                       |||:...|..||.:...:|....|        |:.:||
Mouse   430 ITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAG--------TSILFG 486

  Fly   973 VFL-------IRGRPYNGDDLVNDLRLCGSM-SAFLALSWNVLLP---IGLITLSVVDYKASLSN 1026
            |.:       ..|.....||:   .::.|.. :.:..|.|.::.|   :.::.:|:|.::..
Mouse   487 VLIEAIGVAWFYGVQQFSDDI---KQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPP--- 545

  Fly  1027 QFYYWRGKSYFTYWSRKMGSLIQIGVLLVIPVTAIIQIYRYLAHGPPDILERIQLLYRPPEEGEE 1091
              :|  |...|..|:..:|.:|....:.::|:.|   .|::.:. |....|::.....|.::.:.
Mouse   546 --HY--GAYIFPDWANALGWIIATSSMAMVPIYA---TYKFCSL-PGSFREKLAYAITPEKDRQL 602

  Fly  1092 PRRPSARQ 1099
            ..|...||
Mouse   603 VDRGEVRQ 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bdg	NP_611064.2	SLC5-6-like_sbd	501..976	CDD:271356	137/527 (26%)
Slc6a3	NP_034150.1	SLC5-6-like_sbd	60..613	CDD:444915	164/669 (25%)
		Interaction with TGFB1I1. /evidence=ECO:0000250	560..589		6/32 (19%)