DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sli and SLIT2

DIOPT Version :9

Sequence 1:NP_001261017.1 Gene:sli / 36746 FlyBaseID:FBgn0264089 Length:2157 Species:Drosophila melanogaster
Sequence 2:XP_005248268.1 Gene:SLIT2 / 9353 HGNCID:11086 Length:1533 Species:Homo sapiens


Alignment Length:1516 Identity:678/1516 - (44%)
Similarity:951/1516 - (62%) Gaps:100/1516 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    73 CPRVCSCTGLNVDCSHRGLTSVPRKISADVERLELQGNNLTVIYETDFQRLTKLRMLQLTDNQIH 137
            ||..|||:|..|||....|.||||.|..:.|||:|.|||:|.|.:|||..|..||:|||.:|:|.
Human    28 CPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKIS 92

  Fly   138 TIERNSFQDLVSLERLRLNNNRLKAIPENFVTSSASLLRLDISNNVITTVGRRVFKGAQSLRSLQ 202
            ||||.:||||..|||||||.|.|:..||.....:|.|.|||:|.|.|..:.|:.|:||..:::||
Human    93 TIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQ 157

  Fly   203 LDNNQITCLDEHAFKGLVELEILTLNNNNLTSLPHNIFGGLGRLRALRLSDNPFACDCHLSWLSR 267
            ||.|||:|:::.||:.|.:||:|||||||:|.|....|..:.:||..||..|...|||||:|||.
Human   158 LDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSD 222

  Fly   268 FLRSATRLAPYTRCQSPSQLKGQNVADLHDQEFKCSGLTE-H----APMECGAENSCPHPCRCAD 327
            :||...|:..||:|..||.|:|.|||::..:||.||...| |    || .|...: ||..|.|::
Human   223 WLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSDEEEGHQSFMAP-SCSVLH-CPAACTCSN 285

  Fly   328 GIVDCREKSLTSVPVTLPDDTTELRLEQNFITELPPKSFSSFRRLRRIDLSNNNISRIAHDALSG 392
            .|||||.|.||.:|..||:..||:|||||.|..:||.:||.:::|||||||||.||.:|.||..|
Human   286 NIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQG 350

  Fly   393 LKQLTTLVLYGNKIKDLPSGVFKGLGSLQLLLLNANEISCIRKDAFRDLHSLSLLSLYDNNIQSL 457
            |:.|.:||||||||.:||..:|:||.||||||||||:|:|:|.|||:|||:|:|||||||.:|::
Human   351 LRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTI 415

  Fly   458 ANGTFDAMKSIKTVHLAKNPFICDCNLRWLADYLHKNPIETSGARCESPKRMHRRRIESLREEKF 522
            |.|||..:::|:|:|||:|||||||:|:|||||||.||||||||||.||:|:..:||..::.:||
Human   416 AKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKF 480

  Fly   523 KCS---------WDELRMKLSGECRMDSDCPAMCHCEGTTVDCTGRGLKEIPRDIPLHTTELLLN 578
            :||         .::.|.||||:|..|..||..|.||||||||:.:.|.:||..||.:|.||.||
Human   481 RCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLN 545

  Fly   579 DNELGRISSDGLFGRLPHLVKLELKRNQLTGIEPNAFEGASHIQELQLGENKIKEISNKMFLGLH 643
            :||...:.:.|:|.:||.|.|:....|::|.||..||||||.:.|:.|..|:::.:.:|||.||.
Human   546 NNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLE 610

  Fly   644 QLKT------------------------LNLYDNQISCVMPGSFEHLNSLTSLNLASNPFNCNCH 684
            .|||                        |:||||||:.|.||:|:.|:||::|||.:|||||||:
Human   611 SLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCY 675

  Fly   685 LAWFAEWLRKKSLNGGAARCGAPSKVRDVQIKDLPHSEFKCSSENSE-GCLGDGYCPPSCTCTGT 748
            |||..||||||.:..|..||..|..::::.|:|:...:|.|...|.: .|.....||..|||..|
Human   676 LAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPTECTCLDT 740

  Fly   749 VVRCSRNQLKEIPRGIPAETSELYLESNEIEQIHYERIRHLRSLTRLDLSNNQITILSNYTFANL 813
            |||||...||.:|:|||.:.:||||:.|:...:..| :.:.:.||.:|||||:|:.|||.:|:|:
Human   741 VVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKE-LSNYKHLTLIDLSNNRISTLSNQSFSNM 804

  Fly   814 TKLSTLIISYNKLQCLQRHALSGLNNLRVLSLHGNRISMLPEGSFEDLKSLTHIALGSNPLYCDC 878
            |:|.|||:|||:|:|:......||.:||:||||||.||::|||:|.||.:|:|:|:|:|||||||
Human   805 TQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPLYCDC 869

  Fly   879 GLKWFSDWIKLDYVEPGIARCAEPEQMKDKLILSTPSSSFVCRGRVRNDILAKCNACFEQPCQNQ 943
            .::|.|||:|.:|.||||||||.|.:|.|||:|:|||..|.|:|.|..:||||||.|...||:|.
Human   870 NMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPVDVNILAKCNPCLSNPCKND 934

  Fly   944 AQCVALPQREYQCLCQPGYHGKHCEFMIDACYGNPCRNNATCTVL--EEGRFSCQCAPGYTGARC 1006
            ..|.:.|...|:|.|..|:.|:.|:..|.||..|||::..||.:.  ||..|.|.||.|:.|..|
Human   935 GTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENC 999

  Fly  1007 ETNIDDCLGEIKCQNNATCIDGVESYKCECQPGFSGEFCDTKIQFCSPEFNPCANGAKCMDHFTH 1071
            |.|:||| .:..|:||:||:||:.:|.|.|.|.::||.|:.|:.||:.:.|||.:.:||:.....
Human  1000 EVNVDDC-EDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKG 1063

  Fly  1072 YSCDCQAGFHGTNCTDNIDDCQNHMCQNGGTCVDGINDYQCRCPDDYTGKYCEGHNMISMMYPQT 1136
            :.|||..|:.|.:|..:.||||::.|:||..|.|.:|.|.|.||:.|:|.:||...  .|:.|:|
Human  1064 FKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSP--PMVLPRT 1126

  Fly  1137 SPCQNHECKHGVCFQPNAQGSDYLCRCHPGYTGKWCEYLTSISFVHNNSFVELEPLRTRPEANVT 1201
            |||.|.:|::|.  |...:.::.:|:|.|||.|:.||.|.|::|::..|::::...:.||:.|:|
Human  1127 SPCDNFDCQNGA--QCIVRINEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNIT 1189

  Fly  1202 IVFSSAEQNGILMYDGQDAHLAVELFNGRIRVSYDVGNHPVSTMYSFEMVADGKYHAVELLAIKK 1266
            :..::.|.:|||:|.|...|:||||:.||:|.|||.|:||.|.:||.|.:.||.:|.|||||:.:
Human  1190 LQIATDEDSGILLYKGDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQ 1254

  Fly  1267 NFTLRVDRGLARSIINEGSNDYLKLTTPMFLGGLPVDPAQQAYKNWQIRNLTSFKGCMKEVWINH 1331
            :.:|.||.|..:.|.|......|...:|:::||:|......:.:....:|.|||.||::.::||.
Human  1255 SLSLSVDGGNPKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINS 1319

  Fly  1332 KLVDFGNAQRQQKITPGC------ALLEGEQQEEE------DDEQDFMDETPHIKEEPVDPCLEN 1384
            :|.||.....|..|.|||      ....|..|...      :.::.:|.  |...:...||||.|
Human  1320 ELQDFQKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMG--PLCDQRTNDPCLGN 1382

  Fly  1385 KCRRGSRCVPNSNARDGYQCKCKHGQRGRYCDQGEGSTEP------------------PTVTAAS 1431
            ||..|: |:| .|| ..|.|||..|..|..||:.|....|                  |....:|
Human  1383 KCVHGT-CLP-INA-FSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSS 1444

  Fly  1432 -----------TCRKEQVREYYTEND----CRSRQPLKYAKCVGGC-GNQCCAAKIVRRRKVRMV 1480
                       :||.|::|:||.:..    |::.:.:...:|.||| |.|||.....:|||....
Human  1445 GYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFE 1509

  Fly  1481 CSNNRKYIKNLDIVRKCGCTK 1501
            |::...::..::.|.|||||:
Human  1510 CTDGSSFVDEVEKVVKCGCTR 1530

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sliNP_001261017.1 LRRNT 73..103 CDD:214470 15/29 (52%)
leucine-rich repeat 83..104 CDD:275380 9/20 (45%)
LRR_8 102..160 CDD:290566 36/57 (63%)
leucine-rich repeat 105..125 CDD:275380 11/19 (58%)
LRR_RI <119..259 CDD:238064 69/139 (50%)
leucine-rich repeat 126..149 CDD:275380 15/22 (68%)
LRR_8 149..208 CDD:290566 28/58 (48%)
leucine-rich repeat 150..173 CDD:275380 11/22 (50%)
leucine-rich repeat 174..197 CDD:275380 11/22 (50%)
LRR_8 197..256 CDD:290566 28/58 (48%)
leucine-rich repeat 198..221 CDD:275380 11/22 (50%)
leucine-rich repeat 222..245 CDD:275380 12/22 (55%)
leucine-rich repeat 246..371 CDD:275380 62/129 (48%)
LRRCT 254..303 CDD:214507 24/48 (50%)
LRRNT 319..350 CDD:214470 15/30 (50%)
LRR_8 349..406 CDD:290566 35/56 (63%)
LRR_4 371..411 CDD:289563 26/39 (67%)
leucine-rich repeat 372..395 CDD:275380 16/22 (73%)
leucine-rich repeat 396..415 CDD:275380 11/18 (61%)
leucine-rich repeat 420..443 CDD:275380 17/22 (77%)
leucine-rich repeat 444..465 CDD:275380 13/20 (65%)
leucine-rich repeat 468..480 CDD:275378 8/11 (73%)
LRRCT 476..525 CDD:214507 32/48 (67%)
leucine-rich repeat 484..545 CDD:275380 35/69 (51%)
LRRNT 542..574 CDD:214470 17/31 (55%)
leucine-rich repeat 552..570 CDD:275380 9/17 (53%)
leucine-rich repeat 572..596 CDD:275380 10/23 (43%)
LRR_RI <574..>678 CDD:238064 50/127 (39%)
LRR_8 595..655 CDD:290566 29/83 (35%)
leucine-rich repeat 597..620 CDD:275380 11/22 (50%)
leucine-rich repeat 621..644 CDD:275380 8/22 (36%)
leucine-rich repeat 645..668 CDD:275380 15/46 (33%)
leucine-rich repeat 669..756 CDD:275380 41/87 (47%)
LRRCT 677..726 CDD:214507 23/48 (48%)
LRRNT 739..770 CDD:214470 17/30 (57%)
leucine-rich repeat 757..791 CDD:275380 12/33 (36%)
LRR_4 770..807 CDD:289563 15/36 (42%)
LRR_8 790..850 CDD:290566 33/59 (56%)
LRR_4 791..830 CDD:289563 23/38 (61%)
leucine-rich repeat 792..815 CDD:275380 13/22 (59%)
LRR_4 814..863 CDD:289563 28/48 (58%)
leucine-rich repeat 816..839 CDD:275380 11/22 (50%)
leucine-rich repeat 840..861 CDD:275380 14/20 (70%)
LRRCT 872..920 CDD:214507 31/47 (66%)
EGF 935..966 CDD:278437 11/30 (37%)
EGF_CA 971..1007 CDD:238011 16/37 (43%)
EGF_CA 1009..1045 CDD:238011 17/35 (49%)
EGF_CA 1055..1086 CDD:238011 10/30 (33%)
EGF_CA 1088..1124 CDD:238011 16/35 (46%)
Laminin_G_1 1204..1335 CDD:278483 52/130 (40%)
CT 1435..1504 CDD:214482 23/72 (32%)
SLIT2XP_005248268.1 LRRNT 27..58 CDD:214470 15/29 (52%)
leucine-rich repeat 38..56 CDD:275380 9/17 (53%)
LRR_8 55..115 CDD:404697 36/59 (61%)
leucine-rich repeat 57..80 CDD:275380 13/22 (59%)
internalin_A 73..>434 CDD:380193 194/362 (54%)
leucine-rich repeat 81..104 CDD:275380 15/22 (68%)
leucine-rich repeat 105..128 CDD:275380 11/22 (50%)
leucine-rich repeat 129..152 CDD:275380 11/22 (50%)
leucine-rich repeat 153..176 CDD:275380 11/22 (50%)
LRR_8 154..211 CDD:404697 28/56 (50%)
leucine-rich repeat 177..200 CDD:275380 12/22 (55%)
leucine-rich repeat 201..329 CDD:275380 62/129 (48%)
LRR_8 307..364 CDD:404697 35/56 (63%)
leucine-rich repeat 330..353 CDD:275380 16/22 (73%)
leucine-rich repeat 354..374 CDD:275380 12/19 (63%)
leucine-rich repeat 378..401 CDD:275380 17/22 (77%)
leucine-rich repeat 402..423 CDD:275380 13/20 (65%)
PCC 407..>470 CDD:188093 42/62 (68%)
leucine-rich repeat 426..527 CDD:275380 57/100 (57%)
LRRNT 509..539 CDD:214470 16/29 (55%)
leucine-rich repeat 541..563 CDD:275380 9/21 (43%)
internalin_A 561..>858 CDD:380193 133/297 (45%)
leucine-rich repeat 564..587 CDD:275380 11/22 (50%)
leucine-rich repeat 588..611 CDD:275380 8/22 (36%)
leucine-rich repeat 612..635 CDD:275380 3/22 (14%)
leucine-rich repeat 636..659 CDD:275380 12/22 (55%)
leucine-rich repeat 660..751 CDD:275380 42/90 (47%)
leucine-rich repeat 752..782 CDD:275380 10/30 (33%)
LRR_8 782..841 CDD:404697 33/58 (57%)
leucine-rich repeat 783..806 CDD:275380 13/22 (59%)
leucine-rich repeat 807..830 CDD:275380 11/22 (50%)
leucine-rich repeat 831..852 CDD:275380 14/20 (70%)
PCC 836..>1017 CDD:188093 93/181 (51%)
leucine-rich repeat 855..867 CDD:275378 7/11 (64%)
EGF_CA 1002..1038 CDD:238011 17/36 (47%)
EGF_CA 1042..1077 CDD:238011 12/34 (35%)
EGF_CA 1080..1116 CDD:238011 16/35 (46%)
hEGF 1134..1155 CDD:403759 6/22 (27%)
LamG 1187..1320 CDD:214598 53/132 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 124 1.000 Domainoid score I5521
eggNOG 1 0.900 - - E2759_KOG4237
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H3516
Inparanoid 1 1.050 1361 1.000 Inparanoid score I132
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45950
OrthoDB 1 1.010 - - D20003at33208
OrthoFinder 1 1.000 - - FOG0001593
OrthoInspector 1 1.000 - - otm40542
orthoMCL 1 0.900 - - OOG6_103623
Panther 1 1.100 - - O PTHR45836
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3290
SonicParanoid 1 1.000 - - X1145
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.870

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