DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sli and RLP35

DIOPT Version :9

Sequence 1:	NP_001261017.1	Gene:	sli / 36746	FlyBaseID:	FBgn0264089	Length:	2157	Species:	Drosophila melanogaster
Sequence 2:	NP_001319521.1	Gene:	RLP35 / 820279	AraportID:	AT3G11080	Length:	943	Species:	Arabidopsis thaliana

Alignment Length:	905	Identity:	205/905 - (22%)
Similarity:	329/905 - (36%)	Gaps:	271/905 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 NVDCSH-RGLTSVPRKISADVERLELQGNNLTVIYETDFQ--RLTKLRMLQLTDNQIHTIERNSF 144
            |.||.: .|:|...:  |.:|..|:|..:.|...:.::..  ||..||:|.||.|.:.....:|.
plant    83 NSDCCNWEGITCDTK--SGEVIELDLSCSWLYGSFHSNSSLFRLQNLRVLDLTQNDLDGEIPSSI 145

  Fly   145 QDLVSLERLRLNNNRLKAIPENFVTSSASLLRLDISNN-----VITTVGRRVFKGAQSLRSLQLD 204
            .:|..|..|.|:.|:...:..:.:.:.:.|..|.:|:|     :.:::|     ....|.||:|.
plant   146 GNLSHLTSLHLSYNQFLGLIPSSIENLSRLTSLHLSSNQFSGQIPSSIG-----NLSHLTSLELS 205

  Fly   205 NNQITCLDEHAFKGLVELEILTLNNNNLTSLPHNIF--------GGLGRLRALRLSDNPFACDCH 261
            :||        |.|.:...|..|:|....|||.|.|        |.|.||..|.||.|.|..:..
plant   206 SNQ--------FSGQIPSSIGNLSNLTFLSLPSNDFFGQIPSSIGNLARLTYLYLSYNNFVGEIP 262

  Fly   262 LSW--LSRF-----------------LRSATRLAPYTRCQSPSQLKG---QNV---ADLHDQEFK 301
            .|:  |::.                 |.:.|||:  ....|.:|..|   .|:   ::|.|.|..
plant   263 SSFGNLNQLIVLQVDSNKLSGNVPISLLNLTRLS--ALLLSHNQFTGTIPNNISLLSNLMDFEAS 325

  Fly   302 CSGLTEHAPMECGAENSCPHPCRCADGIVDCREKSLTSVPVTLPDDTTELRL------------- 353
            .:..|...|                        .||.::|..:..|.::.:|
plant   326 NNAFTGTLP------------------------SSLFNIPPLIRLDLSDNQLNGTLHFGNISSPS 366

  Fly   354 --------EQNFITELPPKSFSSFRRLRRIDLSNNN-------ISRIAH----DALSGLKQLTTL 399
                    ..|||..: |:|.|.|..|...|||:.|       .|..:|    |.|. |..|||.
plant   367 NLQYLIIGSNNFIGTI-PRSLSRFVNLTLFDLSHLNTQCRPVDFSIFSHLKSLDDLR-LSYLTTT 429

  Fly   400 VLYGNKIKDLPSGVFKGLGSLQLL--LLNANEISCIRKD---------------------AFRDL 441
            .:..|.|  ||  .||.|.||.:.  |::|...|.:..|                     ..|..
plant   430 TIDLNDI--LP--YFKTLRSLDISGNLVSATNKSSVSSDPPSQSIQSLYLSGCGITDFPEILRTQ 490

  Fly   442 HSLSLLSLYDNNIQSLANGTFDAMKSIKTVHLAKNPFICDCNLRWLADYLHKNPIETSGARCESP 506
            |.|..|.:.:|.|:....|....:.::..::|:.|.||                      ..||.
plant   491 HELGFLDVSNNKIKGQVPGWLWTLPNLFYLNLSNNTFI----------------------SFESS 533

  Fly   507 KRMHRRRIESLREEKFKCSWDELRMKLSGECRMDSDCPAMCHCEGTTVDCTGRGLKEIPRDI--- 568
            .:.|  .:.|:|:                        |:|.|...:..:.||:    ||..|
plant   534 SKKH--GLSSVRK------------------------PSMIHLFASNNNFTGK----IPSFICGL 568

  Fly   569 -PLHTTELLLNDNELGRISSDGLFGRLPH--------LVKLELKRNQLT-GIEPNAFEGASHIQE 623
             .|:|.:|          |.:...|.:|.        |..|.|::|.|: |:..:.||.   ::.
plant   569 RSLNTLDL----------SENNYNGSIPRCMEKLKSTLFVLNLRQNNLSGGLPKHIFES---LRS 620

  Fly   624 LQLGENKIKEISNKMFLGLHQLKTLNLYDNQISCVMPGSFEHLNSLTSLNLASNPFNCNCHLAWF 688
            |.:|.|.:.....:..:....|:.||:..|:|:...|.....|:.|..|.|.||.|:...|.|.|
plant   621 LDVGHNLLVGKLPRSLIRFSNLEVLNVESNRINDTFPFWLSSLSKLQVLVLRSNAFHGPIHEATF 685

  Fly   689 AEWLRKKSLNGGAARCGAPSKVRDVQIKDLPHSEF-------------------KCSSENSEGCL 734
            .|                      ::|.|:.|:.|                   |...:::|..:
plant   686 PE----------------------LRIIDISHNHFNGTLPTEYFVKWSAMSSLGKNEDQSNEKYM 728

  Fly   735 GDG-YCPPSCTCTGTVVRCSRNQLKEIPRGIPAETSELYLESNEIEQIHYERIRHLRSLTRLDLS 798
            |.| |...|      :|..::....|:.|.:...|: |....|:.|....:.|..|:.|..|:||
plant   729 GSGLYYQDS------MVLMNKGLAMELVRILTIYTA-LDFSGNKFEGEIPKSIGLLKELLVLNLS 786

  Fly   799 NNQITILSNYTFANLTKLSTLIISYNKLQCLQRHALSGLNNLRVLSLHGNRIS-MLPEGS 857
            ||........:..|||.|.:|.:|.|||.......|..|:.|..::...|::: ::|.|:
plant   787 NNAFGGHIPSSMGNLTALESLDVSQNKLTGEIPQELGDLSFLAYMNFSHNQLAGLVPGGT 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sli	NP_001261017.1	LRRNT	73..103	CDD:214470	6/20 (30%)
		leucine-rich repeat	83..104	CDD:275380	7/21 (33%)
		LRR_8	102..160	CDD:290566	18/59 (31%)
		leucine-rich repeat	105..125	CDD:275380	5/21 (24%)
		LRR_RI	<119..259	CDD:238064	44/154 (29%)
		leucine-rich repeat	126..149	CDD:275380	8/22 (36%)
		LRR_8	149..208	CDD:290566	14/63 (22%)
		leucine-rich repeat	150..173	CDD:275380	4/22 (18%)
		leucine-rich repeat	174..197	CDD:275380	5/27 (19%)
		LRR_8	197..256	CDD:290566	24/66 (36%)
		leucine-rich repeat	198..221	CDD:275380	8/22 (36%)
		leucine-rich repeat	222..245	CDD:275380	10/30 (33%)
		leucine-rich repeat	246..371	CDD:275380	33/170 (19%)
		LRRCT	254..303	CDD:214507	15/73 (21%)
		LRRNT	319..350	CDD:214470	4/30 (13%)
		LRR_8	349..406	CDD:290566	22/88 (25%)
		LRR_4	371..411	CDD:289563	16/50 (32%)
		leucine-rich repeat	372..395	CDD:275380	10/33 (30%)
		leucine-rich repeat	396..415	CDD:275380	7/18 (39%)
		leucine-rich repeat	420..443	CDD:275380	6/45 (13%)
		leucine-rich repeat	444..465	CDD:275380	5/20 (25%)
		leucine-rich repeat	468..480	CDD:275378	3/11 (27%)
		LRRCT	476..525	CDD:214507	8/48 (17%)
		leucine-rich repeat	484..545	CDD:275380	5/60 (8%)
		LRRNT	542..574	CDD:214470	10/35 (29%)
		leucine-rich repeat	552..570	CDD:275380	5/21 (24%)
		leucine-rich repeat	572..596	CDD:275380	4/23 (17%)
		LRR_RI	<574..>678	CDD:238064	26/112 (23%)
		LRR_8	595..655	CDD:290566	16/68 (24%)
		leucine-rich repeat	597..620	CDD:275380	8/23 (35%)
		leucine-rich repeat	621..644	CDD:275380	3/22 (14%)
		leucine-rich repeat	645..668	CDD:275380	7/22 (32%)
		leucine-rich repeat	669..756	CDD:275380	21/106 (20%)
		LRRCT	677..726	CDD:214507	11/67 (16%)
		LRRNT	739..770	CDD:214470	5/30 (17%)
		leucine-rich repeat	757..791	CDD:275380	8/33 (24%)
		LRR_4	770..807	CDD:289563	11/36 (31%)
		LRR_8	790..850	CDD:290566	19/59 (32%)
		LRR_4	791..830	CDD:289563	15/38 (39%)
		leucine-rich repeat	792..815	CDD:275380	8/22 (36%)
		LRR_4	814..863	CDD:289563	13/45 (29%)
		leucine-rich repeat	816..839	CDD:275380	8/22 (36%)
		leucine-rich repeat	840..861	CDD:275380	4/19 (21%)
		LRRCT	872..920	CDD:214507
		EGF	935..966	CDD:278437
		EGF_CA	971..1007	CDD:238011
		EGF_CA	1009..1045	CDD:238011
		EGF_CA	1055..1086	CDD:238011
		EGF_CA	1088..1124	CDD:238011
		Laminin_G_1	1204..1335	CDD:278483
		CT	1435..1504	CDD:214482
RLP35	NP_001319521.1	LRRNT_2	39..95	CDD:311940	5/11 (45%)
		PLN00113	79..>658	CDD:331614	153/686 (22%)
		leucine-rich repeat	103..123	CDD:275380	3/19 (16%)
		leucine-rich repeat	127..150	CDD:275380	8/22 (36%)
		leucine-rich repeat	151..174	CDD:275380	4/22 (18%)
		leucine-rich repeat	175..198	CDD:275380	5/27 (19%)
		leucine-rich repeat	199..222	CDD:275380	10/30 (33%)
		leucine-rich repeat	223..246	CDD:275380	7/22 (32%)
		leucine-rich repeat	247..270	CDD:275380	8/22 (36%)
		leucine-rich repeat	271..294	CDD:275380	1/22 (5%)
		leucine-rich repeat	295..318	CDD:275380	5/24 (21%)
		leucine-rich repeat	319..337	CDD:275380	5/41 (12%)
		leucine-rich repeat	343..367	CDD:275380	2/23 (9%)
		leucine-rich repeat	368..388	CDD:275380	5/20 (25%)
		leucine-rich repeat	392..417	CDD:275380	7/24 (29%)
		leucine-rich repeat	443..469	CDD:275380	7/25 (28%)
		leucine-rich repeat	470..492	CDD:275380	1/21 (5%)
		leucine-rich repeat	493..516	CDD:275380	5/22 (23%)
		leucine-rich repeat	517..541	CDD:275380	7/47 (15%)
		leucine-rich repeat	542..570	CDD:275380	9/55 (16%)
		leucine-rich repeat	571..594	CDD:275380	6/32 (19%)
		leucine-rich repeat	596..617	CDD:275380	7/20 (35%)
		leucine-rich repeat	618..641	CDD:275380	3/22 (14%)
		LRR_8	640..698	CDD:316378	20/79 (25%)
		leucine-rich repeat	642..665	CDD:275380	7/22 (32%)
		leucine-rich repeat	716..803	CDD:275380	23/93 (25%)
		PLN00113	<758..864	CDD:331614	26/90 (29%)
		leucine-rich repeat	804..825	CDD:275380	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000