DRSC/TRiP Functional Genomics Resources

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Protein Alignment sli and slit3

DIOPT Version :9

Sequence 1:NP_001261017.1 Gene:sli / 36746 FlyBaseID:FBgn0264089 Length:2157 Species:Drosophila melanogaster
Sequence 2:NP_571811.3 Gene:slit3 / 80354 ZFINID:ZDB-GENE-010306-4 Length:1516 Species:Danio rerio


Alignment Length:1524 Identity:629/1524 - (41%)
Similarity:904/1524 - (59%) Gaps:130/1524 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    73 CPRVCSCTGLNVDCSHRGLTSVPRKISADVERLELQGNNLTVIYETDFQRLTKLRMLQLTDNQIH 137
            ||..|||:|.:|||..:...:|||.|..:.|||:|..||:|.|.:.||..|..||:|.|.:|||.
Zfish    25 CPHKCSCSGSHVDCQGQAFKTVPRGIPRNAERLDLDRNNITRITKVDFSGLKNLRVLHLENNQIS 89

  Fly   138 TIERNSFQDLVSLERLRLNNNRLKAIPENFVTSSASLLRLDISNNVITTVGRRVFKGAQSLRSLQ 202
            .|||.:|:.|..|||:|||.|||:.:||....|:..|.|||:|.|.|..|.|:.|:|..::::||
Zfish    90 VIERGAFEGLKQLERIRLNRNRLQVLPELLFQSTTKLSRLDLSENQIQAVPRKAFRGITTVKNLQ 154

  Fly   203 LDNNQITCLDEHAFKGLVELEILTLNNNNLTSLPHNIFGGLGRLRALRLSDNPFACDCHLSWLSR 267
            ||:|.|:|:::.||:.|.:||||||||||:|.:|.:.|..:.:||.|||..|...|||||||||.
Zfish   155 LDSNHISCIEDGAFRALRDLEILTLNNNNITLIPLSSFNHMPKLRTLRLHSNNLHCDCHLSWLSD 219

  Fly   268 FLRSATRLAPYTRCQSPSQLKGQNVADLHDQEFKCSGLTEHAPMECGAE-NSCPHPCRCADGIVD 331
            :||....|||:|:|.:|:.::|.||.|:..:||.|:|..|..|..|..: ..||..|.|.:.|||
Zfish   220 WLRQRRGLAPFTQCMAPAHMRGLNVPDVQKREFVCTGPVETEPRSCAPQVTICPAACTCNNNIVD 284

  Fly   332 CREKSLTSVPVTLPDDTTELRLEQNFITELPPKSFSSFRRLRRIDLSNNNISRIAHDALSGLKQL 396
            ||.|.||.:|..||:...|:|||||.|..:|..:||::::|:|||||.|.||.||.||.|||:.|
Zfish   285 CRRKGLTEIPANLPEGIVEIRLEQNMIKNIPAGAFSTYKKLKRIDLSKNQISEIAEDAFSGLRSL 349

  Fly   397 TTLVLYGNKIKDLPSGVFKGLGSLQLLLLNANEISCIRKDAFRDLHSLSLLSLYDNNIQSLANGT 461
            |:||||||||.::|.|:|.||.||||||||||:|:|:|.:.|:||.:|:|||||||.:|:::.|.
Zfish   350 TSLVLYGNKIAEIPKGLFDGLVSLQLLLLNANKINCLRVNTFKDLQNLNLLSLYDNKLQTISKGL 414

  Fly   462 FDAMKSIKTVHLAKNPFICDCNLRWLADYLHKNPIETSGARCESPKRMHRRRIESLREEKFKCSW 526
            |..:::|||:|||:|||:|||:|:||||||..||||||||||..|:|:..:||..::.:||:|:.
Zfish   415 FAPLRAIKTLHLAQNPFMCDCHLKWLADYLFDNPIETSGARCSHPRRLANKRISQVKGKKFRCTG 479

  Fly   527 -DELRMKLSGECRMDSDCPAMCHCEGTTVDCTGRGLKEIPRDIPLHTTELLLNDNELGRISSDGL 590
             ::.|.:|||||..|..||..|.||||.|||:...|.:||..:|.|||:|.|||||:..:.:.|.
Zfish   480 AEDYRSRLSGECFQDLVCPERCRCEGTVVDCSNLKLTKIPPHLPEHTTDLRLNDNEISILEATGA 544

  Fly   591 FGRLPHLVKLELKRNQLTGIEPNAFEGASHIQELQLGENKIKEISNKMFLGLHQLKT-------- 647
            |.:||:|.|:.|..|:|..|...||:||..:.||.|..||::.:|.:||.||..|||        
Zfish   545 FKKLPNLRKINLSNNKLRDIREGAFDGAGGVLELLLTGNKLQSVSGRMFKGLIGLKTLMLRSNQI 609

  Fly   648 ----------------LNLYDNQISCVMPGSFEHLNSLTSLNLASNPFNCNCHLAWFAEWLRKKS 696
                            |:||||:||.:.||:|..|:||:::||.|||:.|:|||||...||:|..
Zfish   610 SCVDNATFTGLSSVRLLSLYDNRISTIAPGAFNTLHSLSTINLLSNPYVCDCHLAWLGLWLKKTR 674

  Fly   697 LNGGAARCGAPSKVRDVQIKDLPHSEFKCSSENSEGCLGDG-YCPPSCTCTGTVVRCSRNQLKEI 760
            :..|..||..|:.::::.|:|:...:|.|.......||... .||.||||:.||||||...|:.:
Zfish   675 VVSGNPRCQKPAFLKEIPIQDVAMPDFSCDGAEENVCLPSAPRCPESCTCSETVVRCSNRGLRSL 739

  Fly   761 PRGIPAETSELYLESNEIEQIHYERIRHLRSLTRLDLSNNQITILSNYTFANLTKLSTLIISYNK 825
            |:.||.:|:|||||.|.:..:..| :.:|:.||.||||||.|:.|:..||:|:|:|:|||:|||:
Zfish   740 PKTIPKDTTELYLEGNLLTSVPKE-LPNLKQLTLLDLSNNSISHLAPLTFSNMTQLATLILSYNQ 803

  Fly   826 LQCLQRHALSGLNNLRVLSLHGNRISMLPEGSFEDLKSLTHIALGSNPLYCDCGLKWFSDWIKLD 890
            ::|:..||..||.:||:|:||||.:|.:|||:|..|.||:|:|||:|||||||.|:|.|.|:|..
Zfish   804 IRCVPVHAFDGLRSLRLLTLHGNDLSTVPEGAFNHLTSLSHLALGANPLYCDCELRWLSQWVKAG 868

  Fly   891 YVEPGIARCAEPEQMKDKLILSTPSSSFVCRGRVRNDILAKCNACFEQPCQNQAQCVALPQREYQ 955
            :.|||||||..|..|.|:|:|:||.:.|.|:|....::::||..|...||||...||:.....|.
Zfish   869 FKEPGIARCTGPPDMADRLLLTTPLNRFQCKGPADLNLMSKCAPCLATPCQNNGTCVSDVTGSYH 933

  Fly   956 CLCQPGYHGKHCEFMIDACYGNPCRNNATCTVLE--EGRFSCQCAPGYTGARCETNIDDCLGEIK 1018
            |.|..||.|::||..|:||...||.|..||.:..  :|::||.|.|||.|.:||.|.||| .:..
Zfish   934 CTCPFGYKGRNCEIPINACISLPCTNGGTCHLTPGLDGQYSCVCPPGYEGQQCELNPDDC-EDND 997

  Fly  1019 CQNNATCIDGVESYKCECQPGFSGEFCDTKIQFCSPEFNPCANGAKCMDHFTHYSCDCQAGFHGT 1083
            |:||:||:||:.:|.|.|.|.:.|:.|:..:..|.|.|:.|.:.:||:.....|.|:|..|:.|.
Zfish   998 CENNSTCVDGINNYTCVCPPNYKGDLCEEVVDPCLPGFDLCQHDSKCVPLSKGYRCECLPGYVGQ 1062

  Fly  1084 NCTDNIDDCQNHMCQNGGTCVDGINDYQCRCPDDYTGKYCEGHNMISMMYPQTSPCQNHECKHG- 1147
            .|..:.:||..:.||:|..|||.||.|.|.|.:.::|.:||.|..: ::...||||...:|::| 
Zfish  1063 QCEQDYNDCLENKCQHGAECVDAINGYTCVCKEGFSGLFCENHPPM-VLLQNTSPCDQSDCQNGS 1126

  Fly  1148 VCFQPNAQGSDYLCRCHPGYTGKWCEYLTSISFVHNNSFVELEPLRTRPEANVTIVFSSAEQNGI 1212
            .|.   ....:.:|||.|||.|..|:.:.::.|:...::|||...|.||..:::...::.:.|||
Zfish  1127 ECL---VMEGEPVCRCLPGYFGTKCQKMVTLHFLGKEAYVELSGTRIRPPMHISFQVATDKDNGI 1188

  Fly  1213 LMYDGQDAHLAVELFNGRIRVSYDVGNHPVSTMYSFEMVADGKYHAVELLAIKKNFTLRVDRGLA 1277
            |:|......||:||:.|.||:.||:..:|.:|:||.|.|.||.:|.||:|...:..:|.||:|..
Zfish  1189 LLYKEDHDPLALELYQGHIRLIYDISKYPPTTVYSVESVNDGLFHTVEVLIQNQTLSLVVDKGTP 1253

  Fly  1278 RSIINEGSNDYLKLTTPMFLGGLP---------VDPAQQAYKNWQIRNLTSFKGCMKEVWINHKL 1333
            :|:........:...|.:::||:|         ..|.|            ||.||:.:|.:|.:|
Zfish  1254 KSLGKLPRPPAVDHNTQLYIGGVPSLIGTSGLRPGPFQ------------SFNGCLHDVRLNGEL 1306

  Fly  1334 VDFGNAQRQQKITPGCALLEG----------------EQQEEEDDEQDFMDETPHIKEEPV---- 1378
            .|.|         .|.|.:||                .|:.:|....|    .|.....|:    
Zfish  1307 QDLG---------AGLAGIEGVLFGCHSCSVCDQGACRQRGDEGVTCD----CPTGHSGPLCEQM 1358

  Fly  1379 ---DPCLENKCRRGSRCVPNSNARDGYQCKCKHGQRGRYCDQGEGST------------------ 1422
               |||..::|..| .||...::   |.|.|..|..|::||:.:.|:                  
Zfish  1359 SSQDPCESSRCVHG-ECVAKGSS---YSCLCVDGYSGQFCDRQDESSACKGLHCVYGECRLTESG 1419

  Fly  1423 EP----------PTVTAASTCRKEQVREY----YTENDCRSRQPLKYAKCVGGCGN-QCCAAKIV 1472
            ||          ||.....||..|.||:|    .....|.|...::..:|...|.: .|||....
Zfish  1420 EPACHCQPGYSGPTCETELTCEGEAVRDYLYRQMAHKICTSTSRVQRLECRHSCSSGLCCAPTKS 1484

  Fly  1473 RRRKVRMVCSNNRKYIKNLDIVRKCGCTK 1501
            ||||:...|.:...:.:.::|..:|||||
Zfish  1485 RRRKLSFKCPDGSSFSEEMEITVECGCTK 1513

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sliNP_001261017.1 LRRNT 73..103 CDD:214470 13/29 (45%)
leucine-rich repeat 83..104 CDD:275380 7/20 (35%)
LRR_8 102..160 CDD:290566 30/57 (53%)
leucine-rich repeat 105..125 CDD:275380 9/19 (47%)
LRR_RI <119..259 CDD:238064 67/139 (48%)
leucine-rich repeat 126..149 CDD:275380 12/22 (55%)
LRR_8 149..208 CDD:290566 28/58 (48%)
leucine-rich repeat 150..173 CDD:275380 12/22 (55%)
leucine-rich repeat 174..197 CDD:275380 11/22 (50%)
LRR_8 197..256 CDD:290566 29/58 (50%)
leucine-rich repeat 198..221 CDD:275380 10/22 (45%)
leucine-rich repeat 222..245 CDD:275380 13/22 (59%)
leucine-rich repeat 246..371 CDD:275380 59/125 (47%)
LRRCT 254..303 CDD:214507 24/48 (50%)
LRRNT 319..350 CDD:214470 15/30 (50%)
LRR_8 349..406 CDD:290566 34/56 (61%)
LRR_4 371..411 CDD:289563 26/39 (67%)
leucine-rich repeat 372..395 CDD:275380 16/22 (73%)
leucine-rich repeat 396..415 CDD:275380 12/18 (67%)
leucine-rich repeat 420..443 CDD:275380 15/22 (68%)
leucine-rich repeat 444..465 CDD:275380 11/20 (55%)
leucine-rich repeat 468..480 CDD:275378 9/11 (82%)
LRRCT 476..525 CDD:214507 29/48 (60%)
leucine-rich repeat 484..545 CDD:275380 32/61 (52%)
LRRNT 542..574 CDD:214470 16/31 (52%)
leucine-rich repeat 552..570 CDD:275380 7/17 (41%)
leucine-rich repeat 572..596 CDD:275380 11/23 (48%)
LRR_RI <574..>678 CDD:238064 49/127 (39%)
LRR_8 595..655 CDD:290566 29/83 (35%)
leucine-rich repeat 597..620 CDD:275380 10/22 (45%)
leucine-rich repeat 621..644 CDD:275380 10/22 (45%)
leucine-rich repeat 645..668 CDD:275380 14/46 (30%)
leucine-rich repeat 669..756 CDD:275380 37/87 (43%)
LRRCT 677..726 CDD:214507 18/48 (38%)
LRRNT 739..770 CDD:214470 17/30 (57%)
leucine-rich repeat 757..791 CDD:275380 13/33 (39%)
LRR_4 770..807 CDD:289563 18/36 (50%)
LRR_8 790..850 CDD:290566 33/59 (56%)
LRR_4 791..830 CDD:289563 22/38 (58%)
leucine-rich repeat 792..815 CDD:275380 13/22 (59%)
LRR_4 814..863 CDD:289563 26/48 (54%)
leucine-rich repeat 816..839 CDD:275380 12/22 (55%)
leucine-rich repeat 840..861 CDD:275380 12/20 (60%)
LRRCT 872..920 CDD:214507 27/47 (57%)
EGF 935..966 CDD:278437 13/30 (43%)
EGF_CA 971..1007 CDD:238011 16/37 (43%)
EGF_CA 1009..1045 CDD:238011 16/35 (46%)
EGF_CA 1055..1086 CDD:238011 9/30 (30%)
EGF_CA 1088..1124 CDD:238011 14/35 (40%)
Laminin_G_1 1204..1335 CDD:278483 44/139 (32%)
CT 1435..1504 CDD:214482 22/72 (31%)
slit3NP_571811.3 LRRNT 24..55 CDD:214470 13/29 (45%)
LRR_8 52..112 CDD:290566 30/59 (51%)
LRR_4 55..92 CDD:289563 18/36 (50%)
leucine-rich repeat 55..77 CDD:275380 11/21 (52%)
LRR_RI <78..211 CDD:238064 64/132 (48%)
leucine-rich repeat 78..101 CDD:275380 12/22 (55%)
leucine-rich repeat 102..125 CDD:275380 12/22 (55%)
leucine-rich repeat 126..149 CDD:275380 11/22 (50%)
LRR_8 148..208 CDD:290566 29/59 (49%)
leucine-rich repeat 150..173 CDD:275380 10/22 (45%)
leucine-rich repeat 174..197 CDD:275380 13/22 (59%)
leucine-rich repeat 198..301 CDD:275380 49/102 (48%)
TPKR_C2 206..255 CDD:301599 24/48 (50%)
LRRNT 271..303 CDD:214470 15/31 (48%)
LRR_8 303..359 CDD:290566 34/55 (62%)
leucine-rich repeat 303..324 CDD:275380 10/20 (50%)
LRR_4 323..363 CDD:289563 26/39 (67%)
leucine-rich repeat 325..348 CDD:275380 16/22 (73%)
leucine-rich repeat 349..369 CDD:275380 13/19 (68%)
leucine-rich repeat 373..393 CDD:275380 13/19 (68%)
LRR_8 379..431 CDD:290566 27/51 (53%)
leucine-rich repeat 397..420 CDD:275380 11/22 (50%)
leucine-rich repeat 421..476 CDD:275380 34/54 (63%)
TPKR_C2 429..>459 CDD:301599 23/29 (79%)
LRRNT 497..527 CDD:214470 15/29 (52%)
leucine-rich repeat 506..528 CDD:275380 10/21 (48%)
LRR_4 527..566 CDD:289563 17/38 (45%)
leucine-rich repeat 529..550 CDD:275380 9/20 (45%)
LRR_8 549..609 CDD:290566 24/59 (41%)
leucine-rich repeat 551..574 CDD:275380 10/22 (45%)
leucine-rich repeat 575..598 CDD:275380 10/22 (45%)
LRR_8 598..656 CDD:290566 19/57 (33%)
leucine-rich repeat 599..622 CDD:275380 3/22 (14%)
leucine-rich repeat 623..646 CDD:275380 11/22 (50%)
leucine-rich repeat 647..769 CDD:275380 50/122 (41%)
LRRCT 655..704 CDD:214507 18/48 (38%)
LRRNT 718..749 CDD:214470 17/30 (57%)
leucine-rich repeat 727..746 CDD:275378 10/18 (56%)
LRR_4 748..787 CDD:289563 18/39 (46%)
LRR_8 768..828 CDD:290566 33/59 (56%)
LRR_4 768..808 CDD:289563 22/39 (56%)
leucine-rich repeat 770..793 CDD:275380 13/22 (59%)
leucine-rich repeat 794..817 CDD:275380 12/22 (55%)
LRR_TYP 815..838 CDD:197687 13/22 (59%)
leucine-rich repeat 818..839 CDD:275380 12/20 (60%)
LRRCT 850..899 CDD:214507 27/48 (56%)
EGF_CA <917..946 CDD:238011 12/28 (43%)
EGF_CA 949..987 CDD:238011 16/37 (43%)
EGF_CA 991..1025 CDD:238011 15/34 (44%)
EGF_CA 1028..1065 CDD:238011 11/36 (31%)
EGF_CA 1067..1103 CDD:238011 14/35 (40%)
Laminin_G_2 1182..1305 CDD:280389 43/134 (32%)
GHB_like <1457..1512 CDD:304424 15/54 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 69 1.000 Domainoid score I9572
eggNOG 1 0.900 - - E2759_KOG4237
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1305 1.000 Inparanoid score I151
OMA 1 1.010 - - QHG45950
OrthoDB 1 1.010 - - D20003at33208
OrthoFinder 1 1.000 - - FOG0001593
OrthoInspector 1 1.000 - - otm24689
orthoMCL 1 0.900 - - OOG6_103623
Panther 1 1.100 - - O PTHR45836
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3290
SonicParanoid 1 1.000 - - X1145
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1514.870

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