DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sli and amigo1

DIOPT Version :9

Sequence 1:	NP_001261017.1	Gene:	sli / 36746	FlyBaseID:	FBgn0264089	Length:	2157	Species:	Drosophila melanogaster
Sequence 2:	XP_017946836.1	Gene:	amigo1 / 779983	XenbaseID:	XB-GENE-922133	Length:	508	Species:	Xenopus tropicalis

Alignment Length:	433	Identity:	101/433 - (23%)
Similarity:	159/433 - (36%)	Gaps:	133/433 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 SCPHPCRCADGIVDCREKSLTSVPVTLPDDTTELRLEQNFITELPPK-SFSSFRRLRRIDLSNNN 381
            :|...|.||..|:.|.:|.|:.||..||:.|..|.|..|.|:.|..: :....:||..:.||:|:
Frog    32 NCQTTCVCASDIISCPKKELSFVPSGLPNYTAVLDLSHNIISRLRAEWAPEPLKRLHTLVLSHNS 96

  Fly   382 ISRIAHDALSGLKQLTTLVLYGNKIKDLPSGVFKGLGSLQLLLLNANEISCIRKDAFRD------ 440
            ||.::.:|.....||..|.|..||:..|...||..|..|::|||..|:|..|.:.||.|
Frog    97 ISFVSSEAFLLTPQLRYLDLSCNKLNSLEENVFSALHRLEVLLLFQNQIERIDRTAFDDITLLQK 161

  Fly   441 ---------------------LHSLSLLSLYDNNIQS------------LANGTFDAMKSIKTVH 472
                                 |..|.||.|..|.:::            |:||          ::
Frog   162 IYLSHNRVTRFPLELVKDGEKLPELVLLDLSSNRLKNLPVHQLKILPAWLSNG----------IY 216

  Fly   473 LAKNPFICDCNL-----RWLADYLHKNPIETSGARCESPKRMHRRRIESLREEKFKCSWDELRMK 532
            |..||..|||:|     .|                       |.|::.|:.:.:     :||..:
Frog   217 LHGNPLTCDCDLYGLFWNW-----------------------HVRQLASVMDFQ-----EELLCQ 253

  Fly   533 LSGECRMDSDCPAMCHCEGTTVDCTGRG-------LKEIPRDIPLHTTELLLNDNELGRISSDGL 590
            |..:.|..|        :.|.|....|.       ::|...:..|..|.:|..|::...::...:
Frog   254 LYSQPRPPS--------QTTNVFLLNRSDGLNCSVVREAGMEAYLGETVILNCDSKQKSVNQVWV 310

  Fly   591 FGRLPHLVKLELKRNQLTGIEPNAFEGASHIQELQLGENKIKEISNKMFLGLHQLKTLNLYDNQI 655
                       ...|:....:||...|...|..|..|..:|:.|         |::....|
Frog   311 -----------TPSNEWVQAQPNRSAGNRSISVLSDGSLQIRPI---------QVEDRGTY---- 351

  Fly   656 SCVMPGSFEHLNSLTSLNLASNPFNCNCHLAWFAEWLRKKSLN 698
            :|...|  |.||.  :|.:....||       |.:.:.:.:||
Frog   352 TCYAQG--ELLNE--TLYVTLTVFN-------FTQHVHQDTLN 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sli	NP_001261017.1	LRRNT	73..103	CDD:214470
		leucine-rich repeat	83..104	CDD:275380
		LRR_8	102..160	CDD:290566
		leucine-rich repeat	105..125	CDD:275380
		LRR_RI	<119..259	CDD:238064
		leucine-rich repeat	126..149	CDD:275380
		LRR_8	149..208	CDD:290566
		leucine-rich repeat	150..173	CDD:275380
		leucine-rich repeat	174..197	CDD:275380
		LRR_8	197..256	CDD:290566
		leucine-rich repeat	198..221	CDD:275380
		leucine-rich repeat	222..245	CDD:275380
		leucine-rich repeat	246..371	CDD:275380	18/53 (34%)
		LRRCT	254..303	CDD:214507
		LRRNT	319..350	CDD:214470	13/30 (43%)
		LRR_8	349..406	CDD:290566	18/57 (32%)
		LRR_4	371..411	CDD:289563	15/39 (38%)
		leucine-rich repeat	372..395	CDD:275380	7/22 (32%)
		leucine-rich repeat	396..415	CDD:275380	7/18 (39%)
		leucine-rich repeat	420..443	CDD:275380	11/49 (22%)
		leucine-rich repeat	444..465	CDD:275380	8/32 (25%)
		leucine-rich repeat	468..480	CDD:275378	3/11 (27%)
		LRRCT	476..525	CDD:214507	10/53 (19%)
		leucine-rich repeat	484..545	CDD:275380	10/65 (15%)
		LRRNT	542..574	CDD:214470	5/38 (13%)
		leucine-rich repeat	552..570	CDD:275380	4/24 (17%)
		leucine-rich repeat	572..596	CDD:275380	3/23 (13%)
		LRR_RI	<574..>678	CDD:238064	19/103 (18%)
		LRR_8	595..655	CDD:290566	11/59 (19%)
		leucine-rich repeat	597..620	CDD:275380	4/22 (18%)
		leucine-rich repeat	621..644	CDD:275380	5/22 (23%)
		leucine-rich repeat	645..668	CDD:275380	5/22 (23%)
		leucine-rich repeat	669..756	CDD:275380	6/30 (20%)
		LRRCT	677..726	CDD:214507	5/22 (23%)
		LRRNT	739..770	CDD:214470
		leucine-rich repeat	757..791	CDD:275380
		LRR_4	770..807	CDD:289563
		LRR_8	790..850	CDD:290566
		LRR_4	791..830	CDD:289563
		leucine-rich repeat	792..815	CDD:275380
		LRR_4	814..863	CDD:289563
		leucine-rich repeat	816..839	CDD:275380
		leucine-rich repeat	840..861	CDD:275380
		LRRCT	872..920	CDD:214507
		EGF	935..966	CDD:278437
		EGF_CA	971..1007	CDD:238011
		EGF_CA	1009..1045	CDD:238011
		EGF_CA	1055..1086	CDD:238011
		EGF_CA	1088..1124	CDD:238011
		Laminin_G_1	1204..1335	CDD:278483
		CT	1435..1504	CDD:214482
amigo1	XP_017946836.1	leucine-rich repeat	61..86	CDD:275380	6/24 (25%)
		LRR	<65..311	CDD:227223	66/302 (22%)
		LRR_8	86..145	CDD:338972	23/58 (40%)
		leucine-rich repeat	87..110	CDD:275380	7/22 (32%)
		leucine-rich repeat	111..134	CDD:275380	9/22 (41%)
		leucine-rich repeat	135..158	CDD:275380	10/22 (45%)
		leucine-rich repeat	159..185	CDD:275380	1/25 (4%)
		leucine-rich repeat	186..209	CDD:275380	5/22 (23%)
		IG_like	286..370	CDD:214653	21/111 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910