DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sli and Slitrk1

DIOPT Version :9

Sequence 1:NP_001261017.1 Gene:sli / 36746 FlyBaseID:FBgn0264089 Length:2157 Species:Drosophila melanogaster
Sequence 2:NP_951020.1 Gene:Slitrk1 / 76965 MGIID:2679446 Length:696 Species:Mus musculus


Alignment Length:705 Identity:172/705 - (24%)
Similarity:282/705 - (40%) Gaps:201/705 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 GVITEARC-PRVCSCT----GLNVDCSHRGLTSVPR--KISADVERLELQGNNLTVIYETDFQRL 123
            |.:|...| .::|||.    .|:|||..:|.||:.|  ..::....|.|.||:||.::..:|...
Mouse    17 GNVTGDVCKEKICSCNEIEGDLHVDCEKKGFTSLQRFTAPTSQFYHLFLHGNSLTRLFPNEFANF 81

  Fly   124 TKLRMLQLTDNQIHTIERNSFQDLVSLERLRLNNNRLKAIPENFVTSSASLLRLDISNNVITTVG 188
            .....|.:.:|.:|.|...:|..|..::||.:|||::|:.                        .
Mouse    82 YNAVSLHMENNGLHEIVPGAFLGLQLVKRLHINNNKIKSF------------------------R 122

  Fly   189 RRVFKGAQSLRSLQLDNNQITCLDEHAFKGLVELEILTLNNNNLTSLPHNIFGGL---------G 244
            ::.|.|...|..||.|.|.:..:|..||:.|.:||:|.||:|.:::||.|:|..:         .
Mouse   123 KQTFLGLDDLEYLQADFNLLRDIDPGAFQDLNKLEVLILNDNLISTLPANVFQYVPITHLDLRGN 187

  Fly   245 RLRAL---------------RLSDNPFACDCHLSWLSRFLRSATRLAPYTR--CQSPSQLKGQNV 292
            ||:.|               .|.|||:.|.|.|..|..:|.:..:.|...|  |::|::|:|:::
Mouse   188 RLKTLPYEEVLEQIPGIAEILLEDNPWDCTCDLLSLKEWLENIPKNALIGRVVCEAPTRLQGKDL 252

  Fly   293 ADLHDQE------------------------------FKCSGLTEHA------------------ 309
            .:..:|:                              ||.:|..|||                  
Mouse   253 NETTEQDLCPLKNRVDSSLPAPPAQEETFAPGPLPTPFKTNGQDEHATPGAVPNGGTKIPGNWQL 317

  Fly   310 ------PMECGAENS--------CPHPCRC----ADGI-VDCREKSLTSVPVTLP--DDTTELRL 353
                  |:..|:..:        ||..|.|    ..|: ::|..::::|:....|  .:..||.|
Mouse   318 KIKPTPPIATGSARNKPPVHGLPCPGGCSCDHIPGSGLKMNCNNRNVSSLADLKPKLSNVQELFL 382

  Fly   354 EQNFITELPPKSFSSFRRLRRIDLSNNNISRIAH-------------------DALS-----GLK 394
            ..|.|..:....|..::.|..:||.||||:.|.:                   |.||     ||:
Mouse   383 RDNKIHSIRKSHFVDYKNLILLDLGNNNIANIENNTFKNLLDLRWLYMDSNYLDTLSREKFAGLQ 447

  Fly   395 QLTTLVLYGNKIKDLPSGVFKGLGSLQLLLLNANEISCIRKDAFRDLHSLSLLSLYDNNIQSL-A 458
            .|..|.:..|.|:.:..|.|..:..|::|:||.|.:..:..|.|..: |||.|||::|....| .
Mouse   448 NLEYLNVEYNAIQLILPGTFNAMPKLRILILNNNLLRSLPVDVFAGV-SLSKLSLHNNYFMYLPV 511

  Fly   459 NGTFDAMKSIKTVHLAKNPFICDCNL----RWLADYLHKNPIETSGARCESPKRMHRRRIESLRE 519
            .|..|.:.||..:.|..||:.|.|.:    :| |:.| .:.:..|..:||:|....|:....|..
Mouse   512 AGVLDQLTSIIQIDLHGNPWECSCTIVPFKQW-AERL-GSEVLMSDLKCETPVNFFRKDFMLLSN 574

  Fly   520 EKFKCSWDELRMKLSGECRMDSDCPAM-CHCEGTTVDCTGRGLKEIPRDIPLHTTELLLNDNELG 583
            |:. |  .:|..::|         |.: .|.:.:|      ||.|    ...|:...|    :..
Mouse   575 EEI-C--PQLYARIS---------PTLTSHSKNST------GLAE----TGTHSNSYL----DTS 613

  Fly   584 RISSDGLFGRLPHL-------------VKLELKRNQLTGIEPNAFEGASHIQELQ 625
            |:|...|   :|.|             :.:.:.||:......:|...||.|..||
Mouse   614 RVSISVL---VPGLLLVFVTSAFTVVGMLVFILRNRKRSKRRDANSSASEINSLQ 665

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sliNP_001261017.1 LRRNT 73..103 CDD:214470 12/36 (33%)
leucine-rich repeat 83..104 CDD:275380 7/22 (32%)
LRR_8 102..160 CDD:290566 18/57 (32%)
leucine-rich repeat 105..125 CDD:275380 7/19 (37%)
LRR_RI <119..259 CDD:238064 41/163 (25%)
leucine-rich repeat 126..149 CDD:275380 6/22 (27%)
LRR_8 149..208 CDD:290566 13/58 (22%)
leucine-rich repeat 150..173 CDD:275380 6/22 (27%)
leucine-rich repeat 174..197 CDD:275380 2/22 (9%)
LRR_8 197..256 CDD:290566 25/82 (30%)
leucine-rich repeat 198..221 CDD:275380 9/22 (41%)
leucine-rich repeat 222..245 CDD:275380 10/31 (32%)
leucine-rich repeat 246..371 CDD:275380 40/210 (19%)
LRRCT 254..303 CDD:214507 16/80 (20%)
LRRNT 319..350 CDD:214470 8/37 (22%)
LRR_8 349..406 CDD:290566 22/80 (28%)
LRR_4 371..411 CDD:289563 17/63 (27%)
leucine-rich repeat 372..395 CDD:275380 13/46 (28%)
leucine-rich repeat 396..415 CDD:275380 5/18 (28%)
leucine-rich repeat 420..443 CDD:275380 7/22 (32%)
leucine-rich repeat 444..465 CDD:275380 9/21 (43%)
leucine-rich repeat 468..480 CDD:275378 4/11 (36%)
LRRCT 476..525 CDD:214507 14/52 (27%)
leucine-rich repeat 484..545 CDD:275380 13/64 (20%)
LRRNT 542..574 CDD:214470 7/32 (22%)
leucine-rich repeat 552..570 CDD:275380 4/17 (24%)
leucine-rich repeat 572..596 CDD:275380 4/23 (17%)
LRR_RI <574..>678 CDD:238064 14/65 (22%)
LRR_8 595..655 CDD:290566 10/44 (23%)
leucine-rich repeat 597..620 CDD:275380 5/35 (14%)
leucine-rich repeat 621..644 CDD:275380 3/5 (60%)
leucine-rich repeat 645..668 CDD:275380
leucine-rich repeat 669..756 CDD:275380
LRRCT 677..726 CDD:214507
LRRNT 739..770 CDD:214470
leucine-rich repeat 757..791 CDD:275380
LRR_4 770..807 CDD:289563
LRR_8 790..850 CDD:290566
LRR_4 791..830 CDD:289563
leucine-rich repeat 792..815 CDD:275380
LRR_4 814..863 CDD:289563
leucine-rich repeat 816..839 CDD:275380
leucine-rich repeat 840..861 CDD:275380
LRRCT 872..920 CDD:214507
EGF 935..966 CDD:278437
EGF_CA 971..1007 CDD:238011
EGF_CA 1009..1045 CDD:238011
EGF_CA 1055..1086 CDD:238011
EGF_CA 1088..1124 CDD:238011
Laminin_G_1 1204..1335 CDD:278483
CT 1435..1504 CDD:214482
Slitrk1NP_951020.1 leucine-rich repeat 39..60 CDD:275380 7/20 (35%)
LRR 1 59..80 7/20 (35%)
leucine-rich repeat 62..83 CDD:275380 7/20 (35%)
LRR 2 83..104 5/20 (25%)
leucine-rich repeat 84..107 CDD:275380 6/22 (27%)
LRR 3 106..128 7/45 (16%)
LRR_8 108..166 CDD:290566 23/81 (28%)
leucine-rich repeat 108..131 CDD:275380 8/46 (17%)
LRR 4 131..152 8/20 (40%)
leucine-rich repeat 132..155 CDD:275380 9/22 (41%)
LRR_8 155..213 CDD:290566 15/57 (26%)
LRR 5 155..176 10/20 (50%)
leucine-rich repeat 156..177 CDD:275380 10/20 (50%)
LRR 6 178..199 3/20 (15%)
TPKR_C2 212..>250 CDD:301599 12/37 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 268..317 6/48 (13%)
leucine-rich repeat 356..372 CDD:275380 2/15 (13%)
LRR 7 376..397 6/20 (30%)
leucine-rich repeat 377..400 CDD:275380 6/22 (27%)
LRR 8 400..421 8/20 (40%)
leucine-rich repeat 401..424 CDD:275380 8/22 (36%)
LRR 9 424..445 3/20 (15%)
LRR_8 425..483 CDD:290566 16/57 (28%)
leucine-rich repeat 425..448 CDD:275380 5/22 (23%)
LRR 10 448..469 6/20 (30%)
leucine-rich repeat 449..472 CDD:275380 6/22 (27%)
LRR_8 471..530 CDD:290566 20/59 (34%)
LRR 11 472..493 7/20 (35%)
leucine-rich repeat 473..495 CDD:275380 7/22 (32%)
LRR 12 495..516 9/20 (45%)
leucine-rich repeat 496..520 CDD:275380 9/23 (39%)
TPKR_C2 529..579 CDD:301599 15/54 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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