DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sli and Lrfn4

DIOPT Version :9

Sequence 1:NP_001261017.1 Gene:sli / 36746 FlyBaseID:FBgn0264089 Length:2157 Species:Drosophila melanogaster
Sequence 2:NP_001102978.1 Gene:Lrfn4 / 688721 RGDID:1585286 Length:636 Species:Rattus norvegicus


Alignment Length:268 Identity:81/268 - (30%)
Similarity:104/268 - (38%) Gaps:40/268 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 ARCPRVCSCTGLNVD----CSHRGLTSVPRKISADVERLELQGNNLTVIYETDFQRLTKLRMLQL 131
            |.||..|.|..|:..    |:||||..||..:......|.|..|.:..:...||:.:|.|..|.|
  Rat    15 AACPLPCVCQNLSESLSTLCAHRGLLFVPPNVDRRTVELRLADNFIQALGPPDFRNMTGLVDLTL 79

  Fly   132 TDNQIHTIERNSFQDLVSLERLRLNNNRL-------------------------KAIPENFVTSS 171
            :.|.|..|...||.||.||..|.|:.|||                         :..|..|....
  Rat    80 SRNAITRIGARSFGDLESLRSLHLDGNRLVELGSSSLRGPVNLQHLILSGNQLGRIAPGAFDDFL 144

  Fly   172 ASLLRLDISNNVITTVGRRVFKGAQSLRSLQLDNNQITCLDEHAFKGLVELEILTLNNNNLTSLP 236
            .||..||:|.|.:..|.........:|.:|.||:|.|..|....|..|.:|..|.|.:|.|.:|.
  Rat   145 DSLEDLDVSYNNLRQVPWAGIGSMPALHTLNLDHNLIDALPPGVFAQLSQLSRLDLTSNRLATLA 209

  Fly   237 HNIFGGLGR-------LRALRLSDNPFACDCHLSWLSRFLRSATRLAPYTRCQSPSQLKGQNVAD 294
            .:.....||       ...|..|.||..|:|.|.||.|..|.    .....|.||..|.|:....
  Rat   210 PDPLFSRGRDAEASPSPLVLSFSGNPLHCNCELLWLRRLARP----DDLETCASPPTLAGRYFWA 270

  Fly   295 LHDQEFKC 302
            :.:.||.|
  Rat   271 VPEGEFSC 278

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sliNP_001261017.1 LRRNT 73..103 CDD:214470 12/33 (36%)
leucine-rich repeat 83..104 CDD:275380 7/24 (29%)
LRR_8 102..160 CDD:290566 21/57 (37%)
leucine-rich repeat 105..125 CDD:275380 5/19 (26%)
LRR_RI <119..259 CDD:238064 50/171 (29%)
leucine-rich repeat 126..149 CDD:275380 10/22 (45%)
LRR_8 149..208 CDD:290566 21/83 (25%)
leucine-rich repeat 150..173 CDD:275380 8/47 (17%)
leucine-rich repeat 174..197 CDD:275380 6/22 (27%)
LRR_8 197..256 CDD:290566 20/65 (31%)
leucine-rich repeat 198..221 CDD:275380 9/22 (41%)
leucine-rich repeat 222..245 CDD:275380 6/22 (27%)
leucine-rich repeat 246..371 CDD:275380 19/57 (33%)
LRRCT 254..303 CDD:214507 17/49 (35%)
LRRNT 319..350 CDD:214470
LRR_8 349..406 CDD:290566
LRR_4 371..411 CDD:289563
leucine-rich repeat 372..395 CDD:275380
leucine-rich repeat 396..415 CDD:275380
leucine-rich repeat 420..443 CDD:275380
leucine-rich repeat 444..465 CDD:275380
leucine-rich repeat 468..480 CDD:275378
LRRCT 476..525 CDD:214507
leucine-rich repeat 484..545 CDD:275380
LRRNT 542..574 CDD:214470
leucine-rich repeat 552..570 CDD:275380
leucine-rich repeat 572..596 CDD:275380
LRR_RI <574..>678 CDD:238064
LRR_8 595..655 CDD:290566
leucine-rich repeat 597..620 CDD:275380
leucine-rich repeat 621..644 CDD:275380
leucine-rich repeat 645..668 CDD:275380
leucine-rich repeat 669..756 CDD:275380
LRRCT 677..726 CDD:214507
LRRNT 739..770 CDD:214470
leucine-rich repeat 757..791 CDD:275380
LRR_4 770..807 CDD:289563
LRR_8 790..850 CDD:290566
LRR_4 791..830 CDD:289563
leucine-rich repeat 792..815 CDD:275380
LRR_4 814..863 CDD:289563
leucine-rich repeat 816..839 CDD:275380
leucine-rich repeat 840..861 CDD:275380
LRRCT 872..920 CDD:214507
EGF 935..966 CDD:278437
EGF_CA 971..1007 CDD:238011
EGF_CA 1009..1045 CDD:238011
EGF_CA 1055..1086 CDD:238011
EGF_CA 1088..1124 CDD:238011
Laminin_G_1 1204..1335 CDD:278483
CT 1435..1504 CDD:214482
Lrfn4NP_001102978.1 LRR 1 49..70 5/20 (25%)
leucine-rich repeat 50..73 CDD:275380 5/22 (23%)
PPP1R42 53..203 CDD:411060 44/149 (30%)
LRR 2 73..94 8/20 (40%)
leucine-rich repeat 74..97 CDD:275380 10/22 (45%)
LRR 3 97..118 7/20 (35%)
leucine-rich repeat 98..121 CDD:275380 6/22 (27%)
LRR 4 121..142 2/20 (10%)
leucine-rich repeat 122..146 CDD:275380 2/23 (9%)
LRR 5 146..169 7/22 (32%)
leucine-rich repeat 147..170 CDD:275380 6/22 (27%)
LRR 6 170..191 8/20 (40%)
leucine-rich repeat 171..194 CDD:275380 9/22 (41%)
LRR 7 194..215 6/20 (30%)
leucine-rich repeat 195..213 CDD:275380 6/17 (35%)
LRRCT 234..278 CDD:214507 16/47 (34%)
Ig 281..368 CDD:416386
Ig strand A 281..284 CDD:409353
Ig strand A' 288..291 CDD:409353
Ig strand B 297..305 CDD:409353
Ig strand C 311..316 CDD:409353
Ig strand C' 319..321 CDD:409353
Ig strand D 327..331 CDD:409353
Ig strand E 334..338 CDD:409353
Ig strand F 348..355 CDD:409353
Ig strand G 358..368 CDD:409353
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 556..585
PDZ-binding 633..636
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4237
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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