DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sli and LRTM2

DIOPT Version :9

Sequence 1:	NP_001261017.1	Gene:	sli / 36746	FlyBaseID:	FBgn0264089	Length:	2157	Species:	Drosophila melanogaster
Sequence 2:	XP_016875337.1	Gene:	LRTM2 / 654429	HGNCID:	32443	Length:	427	Species:	Homo sapiens

Alignment Length:	258	Identity:	78/258 - (30%)
Similarity:	120/258 - (46%)	Gaps:	34/258 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 CPRVCSC--TGLNVDCSHRGLTSVPRKISADVERLELQGNNLTVIYETDFQRLTKLRMLQLTDNQ 135
            ||..|.|  ..|.||||..|||:||..:.|....|.|..|.|:.:....|..|:.|:.|.|::|.
Human    96 CPFSCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQRLDLSNNF 160

  Fly   136 IHTIERNSFQDLVSLERLRLNNNRLKAIPENFVTSSASLLRLDISNNVITTVGRRVFKGAQSLRS 200
            :..:.|:.|.||.:|..|:|.||.::.:..:.:..|..|..||:|.|.:..:...:|.|..:|||
Human   161 LDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRS 225

  Fly   201 LQLDNNQITCLDEHAFKGLVELEILTLNNNNLTSLPHNIFGGLGRLRALRLSDNPFACDCHL--- 262
            |.|.:|::..||...|:.|..|::                        |::.|||:.|||:|
Human   226 LSLRSNRLQNLDRLTFEPLANLQL------------------------LQVGDNPWECDCNLREF 266

  Fly   263 -SWLSRFLRSATRLAPYTRCQSPSQLKGQNVADLHDQEFK-CSGLTEHAPMECGAENSCPHPC 323
             .|:..|.....|| ....|..|.:|:|:::..:..:.|. ||.| |......|.:...| ||
Human   267 KHWMEWFSYRGGRL-DQLACTLPKELRGKDMRMVPMEMFNYCSQL-EDENSSAGLDIPGP-PC 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sli	NP_001261017.1	LRRNT	73..103	CDD:214470	15/31 (48%)
		leucine-rich repeat	83..104	CDD:275380	10/20 (50%)
		LRR_8	102..160	CDD:290566	19/57 (33%)
		leucine-rich repeat	105..125	CDD:275380	6/19 (32%)
		LRR_RI	<119..259	CDD:238064	38/139 (27%)
		leucine-rich repeat	126..149	CDD:275380	8/22 (36%)
		LRR_8	149..208	CDD:290566	19/58 (33%)
		leucine-rich repeat	150..173	CDD:275380	6/22 (27%)
		leucine-rich repeat	174..197	CDD:275380	7/22 (32%)
		LRR_8	197..256	CDD:290566	14/58 (24%)
		leucine-rich repeat	198..221	CDD:275380	10/22 (45%)
		leucine-rich repeat	222..245	CDD:275380	1/22 (5%)
		leucine-rich repeat	246..371	CDD:275380	25/83 (30%)
		LRRCT	254..303	CDD:214507	15/53 (28%)
		LRRNT	319..350	CDD:214470	3/5 (60%)
		LRR_8	349..406	CDD:290566
		LRR_4	371..411	CDD:289563
		leucine-rich repeat	372..395	CDD:275380
		leucine-rich repeat	396..415	CDD:275380
		leucine-rich repeat	420..443	CDD:275380
		leucine-rich repeat	444..465	CDD:275380
		leucine-rich repeat	468..480	CDD:275378
		LRRCT	476..525	CDD:214507
		leucine-rich repeat	484..545	CDD:275380
		LRRNT	542..574	CDD:214470
		leucine-rich repeat	552..570	CDD:275380
		leucine-rich repeat	572..596	CDD:275380
		LRR_RI	<574..>678	CDD:238064
		LRR_8	595..655	CDD:290566
		leucine-rich repeat	597..620	CDD:275380
		leucine-rich repeat	621..644	CDD:275380
		leucine-rich repeat	645..668	CDD:275380
		leucine-rich repeat	669..756	CDD:275380
		LRRCT	677..726	CDD:214507
		LRRNT	739..770	CDD:214470
		leucine-rich repeat	757..791	CDD:275380
		LRR_4	770..807	CDD:289563
		LRR_8	790..850	CDD:290566
		LRR_4	791..830	CDD:289563
		leucine-rich repeat	792..815	CDD:275380
		LRR_4	814..863	CDD:289563
		leucine-rich repeat	816..839	CDD:275380
		leucine-rich repeat	840..861	CDD:275380
		LRRCT	872..920	CDD:214507
		EGF	935..966	CDD:278437
		EGF_CA	971..1007	CDD:238011
		EGF_CA	1009..1045	CDD:238011
		EGF_CA	1055..1086	CDD:238011
		EGF_CA	1088..1124	CDD:238011
		Laminin_G_1	1204..1335	CDD:278483
		CT	1435..1504	CDD:214482
LRTM2	XP_016875337.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45836
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010