DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sli and Slit1

DIOPT Version :9

Sequence 1:NP_001261017.1 Gene:sli / 36746 FlyBaseID:FBgn0264089 Length:2157 Species:Drosophila melanogaster
Sequence 2:NP_075242.1 Gene:Slit1 / 65047 RGDID:69307 Length:1531 Species:Rattus norvegicus


Alignment Length:1517 Identity:659/1517 - (43%)
Similarity:929/1517 - (61%) Gaps:113/1517 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    73 CPRVCSCTGLNVDCSHRGLTSVPRKISADVERLELQGNNLTVIYETDFQRLTKLRMLQLTDNQIH 137
            ||.:|:|||..|||...||.::|:.|..:.|||||.|||:|.|::.||..|.:||:|||.:|||.
  Rat    34 CPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIG 98

  Fly   138 TIERNSFQDLVSLERLRLNNNRLKAIPENFVTSSASLLRLDISNNVITTVGRRVFKGAQSLRSLQ 202
            .:||.:|.|:..|||||||.|:|:.:||....::.:|.|||:|.|.:..|.|:.|:||..|::||
  Rat    99 AVERGAFDDMKELERLRLNRNQLQVLPELLFQNNQALSRLDLSENSLQAVPRKAFRGATDLKNLQ 163

  Fly   203 LDNNQITCLDEHAFKGLVELEILTLNNNNLTSLPHNIFGGLGRLRALRLSDNPFACDCHLSWLSR 267
            ||.|||:|::|.||:.|..||:|||||||:|::|.:.|..:.:||..||..|...|||||:|||:
  Rat   164 LDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQ 228

  Fly   268 FLRSATRLAPYTRCQSPSQLKGQNVADLHDQEFKCSGLTEHA--PMECGAENSCPHPCRCADGIV 330
            :||....:..:|:|..|:.|:|.|||::...||.|||..|.|  |....:..|||..|.|::|||
  Rat   229 WLRQRPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQGEAAQVPACTLSSGSCPAMCSCSNGIV 293

  Fly   331 DCREKSLTSVPVTLPDDTTELRLEQNFITELPPKSFSSFRRLRRIDLSNNNISRIAHDALSGLKQ 395
            |||.|.||::|..||:..||:|||.|.|..:||.:||.:|:|||||||||.|:.||.||..||:.
  Rat   294 DCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRS 358

  Fly   396 LTTLVLYGNKIKDLPSGVFKGLGSLQLLLLNANEISCIRKDAFRDLHSLSLLSLYDNNIQSLANG 460
            |.:||||||||.|||.|||.||.:|||||||||:|:|||.|||:||.:|||||||||.|||||.|
  Rat   359 LNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKG 423

  Fly   461 TFDAMKSIKTVHLAKNPFICDCNLRWLADYLHKNPIETSGARCESPKRMHRRRIESLREEKFKCS 525
            ||.::::|:|:|||:|||||||||:||||:|..|||||:||||.||:|:..:||..::.:||:||
  Rat   424 TFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETTGARCASPRRLANKRIGQIKSKKFRCS 488

  Fly   526 WDELRM-------KLSGECRMDSDCPAMCHCEGTTVDCTGRGLKEIPRDIPLHTTELLLNDNELG 583
            ..|...       .|:.||..|..||..|.||.:.|:|:|..|.:||..||..||||.||:||:.
  Rat   489 AKEQYFIPGTEDYHLNSECTSDVACPHKCRCEASVVECSGLKLSKIPERIPQSTTELRLNNNEIS 553

  Fly   584 RISSDGLFGRLPHLVKLELKRNQLTGIEPNAFEGASHIQELQLGENKIKEISNKMFLGLHQLKT- 647
            .:.:.|||.:|.||.|:.|..|:::.||...||||:.:.||.|..|:::.:.:.||.||..|:| 
  Rat   554 ILEATGLFKKLSHLKKINLSNNKVSEIEDGTFEGATSVSELHLTANQLESVRSGMFRGLDGLRTL 618

  Fly   648 -----------------------LNLYDNQISCVMPGSFEHLNSLTSLNLASNPFNCNCHLAWFA 689
                                   |:||||.|:.:.||:|:.|.:|::|||.:|||||||.|||..
  Rat   619 MLRNNRISCIHNDSFTGLRNVRLLSLYDNHITTISPGAFDTLQALSTLNLLANPFNCNCQLAWLG 683

  Fly   690 EWLRKKSLNGGAARCGAPSKVRDVQIKDLPHSEFKCSSENSE-GCLGDGYCPPSCTCTGTVVRCS 753
            :||||:.:..|..||..|..:|.:.::|:...:|:|.....| |||....||..|.|..||||||
  Rat   684 DWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEVGCLPRPQCPQECACLDTVVRCS 748

  Fly   754 RNQLKEIPRGIPAETSELYLESNEIEQIHYERIRHLRSLTRLDLSNNQITILSNYTFANLTKLST 818
            ...|:.:|:|||...:||||:.|:...:. .::...:.|..:|||||:|:.|||.:|.|:::|:|
  Rat   749 NKHLQALPKGIPKNVTELYLDGNQFTLVP-GQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTT 812

  Fly   819 LIISYNKLQCLQRHALSGLNNLRVLSLHGNRISMLPEGSFEDLKSLTHIALGSNPLYCDCGLKWF 883
            ||:|||.|||:...|..||.:||:||||||.:|.|.||.|.|:.||:|:|:|:|||||||.|:|.
  Rat   813 LILSYNALQCIPPLAFQGLRSLRLLSLHGNDVSTLQEGIFADVTSLSHLAIGANPLYCDCHLRWL 877

  Fly   884 SDWIKLDYVEPGIARCAEPEQMKDKLILSTPSSSFVCRGRVRNDILAKCNACFEQPCQNQAQCVA 948
            |.|:|..|.||||||||.|.:|:.||:|:||:..|.|:|.....:.|||:.|...|||||..|..
  Rat   878 SSWVKTGYKEPGIARCAGPPEMEGKLLLTTPAKKFECQGPPSLAVQAKCDPCLSSPCQNQGTCHN 942

  Fly   949 LPQREYQCLCQPGYHGKHCEFMIDACYGNPCRNNATCTVL--EEGRFSCQCAPGYTGARCETNID 1011
            .|...|:|.|..||.|::||..:|:|..|||.|..||...  |:..|:|.|..|:.|..|..|.|
  Rat   943 DPLEVYRCTCPSGYKGRNCEVSLDSCSSNPCGNGGTCHAQEGEDAGFTCSCPSGFEGLTCGMNTD 1007

  Fly  1012 DCLGEIKCQNNATCIDGVESYKCECQPGFSGEFCDTKIQFCSPEFNPCANGAKCMDHFTHYSCDC 1076
            ||: :..|.|...|:||:.:|.|:|...::|..|:..:.||||:.|||.:.|:|:.......|:|
  Rat  1008 DCV-KHDCVNGGVCVDGIGNYTCQCPLQYTGRACEQLVDFCSPDLNPCQHEAQCVGTPEGPRCEC 1071

  Fly  1077 QAGFHGTNCTDNIDDCQNHMCQNGGTCVDGINDYQCRCPDDYTGKYCEGHNMISMMYPQTSPCQN 1141
            ..|:.|.||:.|.|||::|.||||..|||.||.|.|.|.:.|:|:.||     ....|:.| |:.
  Rat  1072 VPGYTGDNCSKNQDDCKDHQCQNGAQCVDEINSYACLCAEGYSGQLCE-----IPPAPRNS-CEG 1130

  Fly  1142 HECKHGV-CFQPNAQGSDYLCRCHPGYTGKWCEYLTSISFVHNNSFVELEPLRTRPEANVTIVFS 1205
            .||::|. |..   |||..:|:|.||:.|..||.|.|::||..:::::...|:..|.||:|:..|
  Rat  1131 TECQNGANCVD---QGSRPVCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPRANITLQVS 1192

  Fly  1206 SAEQNGILMYDGQDAHLAVELFNGRIRVSYDVGNHPVSTMYSFEMVADGKYHAVELLAIKKNFTL 1270
            :||.||||:|:|.:.|:||||:.|.:|||||.|::|.|.:||.|.:.||::|.|||:...:...|
  Rat  1193 TAEDNGILLYNGDNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVTFDQMVNL 1257

  Fly  1271 RVDRGLARSIINEGSNDYLKLTTPMFLGGLPVDPAQQAYKNWQIRNLTSFKGCMKEVWINHKLVD 1335
            .:|.|...::.|.|.:..|....|:::||:|||....|::.|||.|.|||.||::.::||::|.|
  Rat  1258 SIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVNSAAFRLWQILNGTSFHGCIRNLYINNELQD 1322

  Fly  1336 FGNAQRQQKITPGCA------LLEGEQQEEEDDEQDFMDETP----HIK--------EEPVD-PC 1381
            |...|.:..:.|||.      .|.|..|.         :.||    |.:        ::||| ||
  Rat  1323 FTKTQMKPGVVPGCEPCRKLYCLHGICQP---------NATPGPVCHCEAGWGGLHCDQPVDGPC 1378

  Fly  1382 LENKCRRGSRCVPNSNARDGYQCKCKHGQRGRYCDQGEGSTEP---------------------- 1424
            ..:||..| :|||....  .|.|:|:.|..|..|:|.....||                      
  Rat  1379 HGHKCVHG-KCVPLDAL--AYSCQCQDGYSGALCNQVGAVAEPCGGLQCLHGHCQASATRGAHCV 1440

  Fly  1425 --PTVTA-----ASTCRKEQVREYYTEND----CRSRQPLKYAKCVGGC-GNQCCAAKIVRRRKV 1477
              |..:.     .|.||.:.||:::....    |::.:||.:.:|.|.| |..||....::|||:
  Rat  1441 CSPGFSGELCEQESECRGDPVRDFHRVQRGYAICQTTRPLSWVECRGACPGQGCCQGLRLKRRKL 1505

  Fly  1478 RMVCSNNRKYIKNLDIVRKCGC 1499
            ...||:...:.:.::...||||
  Rat  1506 TFECSDGTSFAEEVEKPTKCGC 1527

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sliNP_001261017.1 LRRNT 73..103 CDD:214470 13/29 (45%)
leucine-rich repeat 83..104 CDD:275380 7/20 (35%)
LRR_8 102..160 CDD:290566 33/57 (58%)
leucine-rich repeat 105..125 CDD:275380 11/19 (58%)
LRR_RI <119..259 CDD:238064 67/139 (48%)
leucine-rich repeat 126..149 CDD:275380 12/22 (55%)
LRR_8 149..208 CDD:290566 28/58 (48%)
leucine-rich repeat 150..173 CDD:275380 11/22 (50%)
leucine-rich repeat 174..197 CDD:275380 11/22 (50%)
LRR_8 197..256 CDD:290566 30/58 (52%)
leucine-rich repeat 198..221 CDD:275380 13/22 (59%)
leucine-rich repeat 222..245 CDD:275380 12/22 (55%)
leucine-rich repeat 246..371 CDD:275380 59/126 (47%)
LRRCT 254..303 CDD:214507 21/48 (44%)
LRRNT 319..350 CDD:214470 16/30 (53%)
LRR_8 349..406 CDD:290566 35/56 (63%)
LRR_4 371..411 CDD:289563 27/39 (69%)
leucine-rich repeat 372..395 CDD:275380 16/22 (73%)
leucine-rich repeat 396..415 CDD:275380 14/18 (78%)
leucine-rich repeat 420..443 CDD:275380 18/22 (82%)
leucine-rich repeat 444..465 CDD:275380 17/20 (85%)
leucine-rich repeat 468..480 CDD:275378 8/11 (73%)
LRRCT 476..525 CDD:214507 30/48 (63%)
leucine-rich repeat 484..545 CDD:275380 30/67 (45%)
LRRNT 542..574 CDD:214470 14/31 (45%)
leucine-rich repeat 552..570 CDD:275380 7/17 (41%)
leucine-rich repeat 572..596 CDD:275380 12/23 (52%)
LRR_RI <574..>678 CDD:238064 45/127 (35%)
LRR_8 595..655 CDD:290566 26/83 (31%)
leucine-rich repeat 597..620 CDD:275380 10/22 (45%)
leucine-rich repeat 621..644 CDD:275380 8/22 (36%)
leucine-rich repeat 645..668 CDD:275380 12/46 (26%)
leucine-rich repeat 669..756 CDD:275380 40/87 (46%)
LRRCT 677..726 CDD:214507 21/48 (44%)
LRRNT 739..770 CDD:214470 15/30 (50%)
leucine-rich repeat 757..791 CDD:275380 10/33 (30%)
LRR_4 770..807 CDD:289563 13/36 (36%)
LRR_8 790..850 CDD:290566 33/59 (56%)
LRR_4 791..830 CDD:289563 22/38 (58%)
leucine-rich repeat 792..815 CDD:275380 12/22 (55%)
LRR_4 814..863 CDD:289563 27/48 (56%)
leucine-rich repeat 816..839 CDD:275380 13/22 (59%)
leucine-rich repeat 840..861 CDD:275380 13/20 (65%)
LRRCT 872..920 CDD:214507 29/47 (62%)
EGF 935..966 CDD:278437 14/30 (47%)
EGF_CA 971..1007 CDD:238011 14/37 (38%)
EGF_CA 1009..1045 CDD:238011 13/35 (37%)
EGF_CA 1055..1086 CDD:238011 10/30 (33%)
EGF_CA 1088..1124 CDD:238011 19/35 (54%)
Laminin_G_1 1204..1335 CDD:278483 57/130 (44%)
CT 1435..1504 CDD:214482 20/70 (29%)
Slit1NP_075242.1 LRRNT 33..64 CDD:214470 13/29 (45%)
leucine-rich repeat 43..62 CDD:275380 7/18 (39%)
LRR_8 61..121 CDD:290566 33/59 (56%)
LRR 1 62..83 12/20 (60%)
leucine-rich repeat 63..86 CDD:275380 13/22 (59%)
LRR 2 86..107 11/20 (55%)
LRR_RI <87..275 CDD:238064 90/187 (48%)
leucine-rich repeat 87..110 CDD:275380 12/22 (55%)
LRR_8 109..169 CDD:290566 28/59 (47%)
LRR 3 110..131 11/20 (55%)
leucine-rich repeat 111..134 CDD:275380 11/22 (50%)
LRR 4 134..155 9/20 (45%)
leucine-rich repeat 135..158 CDD:275380 11/22 (50%)
LRR 5 158..179 12/20 (60%)
LRR_8 159..217 CDD:290566 30/57 (53%)
leucine-rich repeat 159..182 CDD:275380 13/22 (59%)
LRR 6 182..203 12/20 (60%)
leucine-rich repeat 183..206 CDD:275380 12/22 (55%)
leucine-rich repeat 207..334 CDD:275380 59/126 (47%)
LRRNT 282..313 CDD:214470 16/30 (53%)
LRR 7 310..331 10/20 (50%)
LRR_8 312..369 CDD:290566 35/56 (63%)
LRR_4 334..373 CDD:289563 26/38 (68%)
LRR 8 334..355 14/20 (70%)
leucine-rich repeat 335..358 CDD:275380 16/22 (73%)
LRR 9 358..379 15/20 (75%)
leucine-rich repeat 359..379 CDD:275380 15/19 (79%)
LRR 10 382..403 16/20 (80%)
leucine-rich repeat 383..406 CDD:275380 18/22 (82%)
LRR_8 389..441 CDD:290566 35/51 (69%)
LRR_RI <398..627 CDD:238064 110/228 (48%)
LRR 11 406..427 17/20 (85%)
leucine-rich repeat 407..428 CDD:275380 17/20 (85%)
leucine-rich repeat 431..528 CDD:275380 49/96 (51%)
leucine-rich repeat 529..566 CDD:275380 17/36 (47%)
LRR 12 541..562 10/20 (50%)
LRR_8 543..601 CDD:290566 26/57 (46%)
LRR_4 543..582 CDD:289563 17/38 (45%)
LRR 13 566..587 8/20 (40%)
leucine-rich repeat 567..590 CDD:275380 10/22 (45%)
LRR_8 589..649 CDD:290566 15/59 (25%)
LRR 14 590..611 6/20 (30%)
leucine-rich repeat 591..614 CDD:275380 8/22 (36%)
LRR 15 614..635 2/20 (10%)
LRR_4 615..654 CDD:289563 8/38 (21%)
leucine-rich repeat 615..638 CDD:275380 2/22 (9%)
LRR 16 638..659 9/20 (45%)
leucine-rich repeat 639..660 CDD:275380 9/20 (45%)
leucine-rich repeat 663..754 CDD:275380 41/90 (46%)
LRRCT 671..719 CDD:214507 21/47 (45%)
LRRNT 733..765 CDD:214470 15/31 (48%)
leucine-rich repeat 755..785 CDD:275380 9/30 (30%)
LRR_8 761..820 CDD:290566 24/59 (41%)
LRR 17 762..783 5/21 (24%)
LRR 18 785..806 11/20 (55%)
LRR_4 786..827 CDD:289563 22/40 (55%)
leucine-rich repeat 786..809 CDD:275380 12/22 (55%)
LRR 19 809..830 11/20 (55%)
leucine-rich repeat 810..830 CDD:275380 11/19 (58%)
LRR 20 833..854 13/20 (65%)
leucine-rich repeat 834..857 CDD:275380 14/22 (64%)
LRRCT 866..915 CDD:214507 29/48 (60%)
EGF_CA 927..962 CDD:238011 14/34 (41%)
EGF_CA 966..1002 CDD:238011 14/35 (40%)
EGF_CA 1005..1041 CDD:238011 13/36 (36%)
EGF_CA 1044..1080 CDD:238011 13/35 (37%)
EGF_CA 1085..1119 CDD:238011 18/33 (55%)
LamG 1186..1319 CDD:214598 58/132 (44%)
GHB_like <1494..1529 CDD:304424 11/34 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 124 1.000 Domainoid score I5380
eggNOG 1 0.900 - - E2759_KOG4237
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1301 1.000 Inparanoid score I144
OMA 1 1.010 - - QHG45950
OrthoDB 1 1.010 - - D20003at33208
OrthoFinder 1 1.000 - - FOG0001593
OrthoInspector 1 1.000 - - otm44679
orthoMCL 1 0.900 - - OOG6_103623
Panther 1 1.100 - - O PTHR45836
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1145
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.840

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