DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sli and NYX

DIOPT Version :9

Sequence 1:NP_001261017.1 Gene:sli / 36746 FlyBaseID:FBgn0264089 Length:2157 Species:Drosophila melanogaster
Sequence 2:NP_001365406.2 Gene:NYX / 60506 HGNCID:8082 Length:476 Species:Homo sapiens


Alignment Length:593 Identity:143/593 - (24%)
Similarity:212/593 - (35%) Gaps:162/593 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 ILLLLRHDAVHAEPYSGGFGSSAVSSGGLGSVGIHIPGGGVGVITEARCPRVCSCT----GLNVD 85
            :|:||.|..|...|.:...|:.|                       ..||..|:|:    |.:|.
Human     1 MLVLLLHAVVLGLPSAWAVGACA-----------------------RACPAACACSTVERGCSVR 42

  Fly    86 CSHRGLTSVPRKISADVERLELQGNNLTVIYETDFQRLTKLRMLQLTDNQIHTIERNSFQDLVSL 150
            |...||..||.::..:...::|..|.|..:.|..|..|..||.|.|..|.:..|...:|:.|..|
Human    43 CDRAGLLRVPAELPCEAVSIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRL 107

  Fly   151 ERLRL-NNNRLKAIPENFVTSSASLLRLDISNNVITTVGRRVFKGAQSLRSLQLDNNQITCLDEH 214
            ..||| :|..|:.:......:.:.|.|||::...:.:|..|:.....:||.|...:|....: ..
Human   108 AELRLAHNGDLRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRV-PG 171

  Fly   215 AFKGLVELEILTLNNNNLTSLPHNIFGGLGRLRALRLSDNPFACDCHLSWLSRFLRSATRLAPYT 279
            |.:||..|....|....:.::..:...||.|||:|.|..|                         
Human   172 ALRGLANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQAN------------------------- 211

  Fly   280 RCQSPSQLKGQNVADLHDQEFKCSGLTEHAPMECGAENSCPHPCRCADGIVDCREKSLTSVPVTL 344
                       .|..:|...|...|:.||                                    
Human   212 -----------RVRAVHAGAFGDCGVLEH------------------------------------ 229

  Fly   345 PDDTTELRLEQNFITELPPKSFSSFRRLRRIDLSNNNISRIAHDALSGLKQLTTLVLYGNKIKDL 409
                  |.|..|.:.|||..:|...||||.::|..|.:.|:|.                      
Human   230 ------LLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVAR---------------------- 266

  Fly   410 PSGVFKGLGSLQLLLLNANEISCIRKDAFRDLHSLSLLSLYDNNIQSLANGTFDAMKSIKTVHLA 474
              ..|..|..|:||.|:.|.|:.:.:.||::|..|..|.|..|.:..||...|.....:..:.|.
Human   267 --AWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLF 329

  Fly   475 KNPFICDCNLRWLADYLHKNPIETSG----ARCESPKRMHRRRIESLREEKFKCSWDEL-----R 530
            :||:.|||.|.||.|::     |.||    ..|.||..:...   .|.:..|..|.|.|     .
Human   330 RNPWCCDCRLEWLRDWM-----EGSGRVTDVPCASPGSVAGL---DLSQVTFGRSSDGLCVDPEE 386

  Fly   531 MKLSGECRMDSDCPAMCHCEGTTVDCTGRGLKEI--PRDIPL----HTTELLLNDNELGRISSDG 589
            :.|:......|..||     .|||......|.::  || :|:    :||..|.|.:....:||.|
Human   387 LNLTTSSPGPSPEPA-----ATTVSRFSSLLSKLLAPR-VPVEEAANTTGGLANASLSDSLSSRG 445

  Fly   590 L--FGRLP 595
            :  .||.|
Human   446 VGGAGRQP 453

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sliNP_001261017.1 LRRNT 73..103 CDD:214470 11/33 (33%)
leucine-rich repeat 83..104 CDD:275380 6/20 (30%)
LRR_8 102..160 CDD:290566 19/58 (33%)
leucine-rich repeat 105..125 CDD:275380 6/19 (32%)
LRR_RI <119..259 CDD:238064 39/140 (28%)
leucine-rich repeat 126..149 CDD:275380 8/22 (36%)
LRR_8 149..208 CDD:290566 16/59 (27%)
leucine-rich repeat 150..173 CDD:275380 6/23 (26%)
leucine-rich repeat 174..197 CDD:275380 6/22 (27%)
LRR_8 197..256 CDD:290566 17/58 (29%)
leucine-rich repeat 198..221 CDD:275380 7/22 (32%)
leucine-rich repeat 222..245 CDD:275380 4/22 (18%)
leucine-rich repeat 246..371 CDD:275380 18/124 (15%)
LRRCT 254..303 CDD:214507 4/48 (8%)
LRRNT 319..350 CDD:214470 0/30 (0%)
LRR_8 349..406 CDD:290566 15/56 (27%)
LRR_4 371..411 CDD:289563 7/39 (18%)
leucine-rich repeat 372..395 CDD:275380 6/22 (27%)
leucine-rich repeat 396..415 CDD:275380 0/18 (0%)
leucine-rich repeat 420..443 CDD:275380 9/22 (41%)
leucine-rich repeat 444..465 CDD:275380 7/20 (35%)
leucine-rich repeat 468..480 CDD:275378 3/11 (27%)
LRRCT 476..525 CDD:214507 17/52 (33%)
leucine-rich repeat 484..545 CDD:275380 17/69 (25%)
LRRNT 542..574 CDD:214470 10/37 (27%)
leucine-rich repeat 552..570 CDD:275380 6/19 (32%)
leucine-rich repeat 572..596 CDD:275380 10/26 (38%)
LRR_RI <574..>678 CDD:238064 8/24 (33%)
LRR_8 595..655 CDD:290566 1/1 (100%)
leucine-rich repeat 597..620 CDD:275380
leucine-rich repeat 621..644 CDD:275380
leucine-rich repeat 645..668 CDD:275380
leucine-rich repeat 669..756 CDD:275380
LRRCT 677..726 CDD:214507
LRRNT 739..770 CDD:214470
leucine-rich repeat 757..791 CDD:275380
LRR_4 770..807 CDD:289563
LRR_8 790..850 CDD:290566
LRR_4 791..830 CDD:289563
leucine-rich repeat 792..815 CDD:275380
LRR_4 814..863 CDD:289563
leucine-rich repeat 816..839 CDD:275380
leucine-rich repeat 840..861 CDD:275380
LRRCT 872..920 CDD:214507
EGF 935..966 CDD:278437
EGF_CA 971..1007 CDD:238011
EGF_CA 1009..1045 CDD:238011
EGF_CA 1055..1086 CDD:238011
EGF_CA 1088..1124 CDD:238011
Laminin_G_1 1204..1335 CDD:278483
CT 1435..1504 CDD:214482
NYXNP_001365406.2 LRR_8 61..115 CDD:404697 18/53 (34%)
leucine-rich repeat 63..82 CDD:275380 6/18 (33%)
leucine-rich repeat 83..106 CDD:275380 8/22 (36%)
leucine-rich repeat 107..131 CDD:275380 6/23 (26%)
leucine-rich repeat 132..155 CDD:275380 6/22 (27%)
PPP1R42 150..310 CDD:411060 53/262 (20%)
leucine-rich repeat 156..178 CDD:275380 7/22 (32%)
leucine-rich repeat 179..202 CDD:275380 4/22 (18%)
leucine-rich repeat 203..226 CDD:275380 8/58 (14%)
LRR_8 227..285 CDD:404697 24/123 (20%)
leucine-rich repeat 227..250 CDD:275380 9/64 (14%)
leucine-rich repeat 251..274 CDD:275380 8/46 (17%)
leucine-rich repeat 275..296 CDD:275380 8/20 (40%)
leucine-rich repeat 323..335 CDD:275378 3/11 (27%)
LRRCT 331..>365 CDD:214507 15/38 (39%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4237
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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