DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sli and slit1b

DIOPT Version :9

Sequence 1:	NP_001261017.1	Gene:	sli / 36746	FlyBaseID:	FBgn0264089	Length:	2157	Species:	Drosophila melanogaster
Sequence 2:	NP_001030147.1	Gene:	slit1b / 561685	ZFINID:	ZDB-GENE-030722-4	Length:	1532	Species:	Danio rerio

Alignment Length:	1531	Identity:	638/1531 - (41%)
Similarity:	900/1531 - (58%)	Gaps:	133/1531 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 CPRVCSCTGLNVDCSHRGLTSVPRKISADVERLELQGNNLTVIYETDFQRLTKLRMLQLTDNQIH 137
            ||..|||||..|||......||||.|....|||:|..||||.|.:.||..|..||:|.|.||||.
Zfish    31 CPPHCSCTGSTVDCHGLAFKSVPRNIPKTTERLDLNANNLTHIGKDDFAGLKHLRILHLMDNQIV 95

  Fly   138 TIERNSFQDLVSLERLRLNNNRLKAIPENFVTSSASLLRLDISNNVITTVGRRVFKGAQSLRSLQ 202
            :|:|.:|.||..|:|||||.|||:.:||.....:.:|.|||:|.|.|..:.||.|:||..:::||
Zfish    96 SIDRGAFSDLKELDRLRLNRNRLQQLPELLFLKNPALSRLDLSENNIQMIPRRAFRGATDIKNLQ 160

  Fly   203 LDNNQITCLDEHAFKGLVELEILTLNNNNLTSLPHNIFGGLGRLRALRLSDNPFACDCHLSWLSR 267
            ||.|.|:|:::.||:.:..||:|||||||::::|.:.|..:.:||..||..|...|||.|||||:
Zfish   161 LDKNHISCIEDGAFRAMRVLEVLTLNNNNISAIPISSFNHMPKLRTFRLHWNSLRCDCQLSWLSQ 225

  Fly   268 FLRSATRLAPYTRCQSPSQLKGQNVADLHDQEFKCSGLTEHAPMECG-AENSCPHPCRCADGIVD 331
            :||....|..||:|.||:.|.|.|:|:|..::|.|:|..:.:|..|| |..|||..|.|.:.|||
Zfish   226 WLRQRPALGLYTQCSSPAHLHGLNLAELQKKDFTCAGALDSSPQPCGLASGSCPPMCSCTNNIVD 290

  Fly   332 CREKSLTSVPVTLPDDTTELRLEQNFITELPPKSFSSFRRLRRIDLSNNNISRIAHDALSGLKQL 396
            ||.|.||::|..:|:..||:|||||.|..:||.:|||::||||||||||.||.||.||..||:.|
Zfish   291 CRGKGLTAIPANMPESMTEIRLEQNGIKSVPPGAFSSYKRLRRIDLSNNQISEIAPDAFHGLRSL 355

  Fly   397 TTLVLYGNKIKDLPSGVFKGLGSLQLLLLNANEISCIRKDAFRDLHSLSLLSLYDNNIQSLANGT 461
            .:||||||||.|||.|||.||.:|:|||||||:|.|:|.:.|:||.:|||||||||.||:||.||
Zfish   356 NSLVLYGNKITDLPRGVFDGLSALELLLLNANKIHCVRVNVFQDLENLSLLSLYDNKIQTLAKGT 420

  Fly   462 FDAMKSIKTVHLAKNPFICDCNLRWLADYLHKNPIETSGARCESPKRMHRRRIESLREEKFKCSW 526
            |..:|||:|:|||:|||:|||.|:||||:|..||||||||||.||:|:..:||..::.:||:||.
Zfish   421 FAPLKSIQTLHLAQNPFVCDCGLKWLADFLRSNPIETSGARCSSPRRLANKRISQIKSKKFRCSA 485

  Fly   527 DELRMKLSG--ECRMDSD------CPAMCHCEGTTVDCTGRGLKEIPRDIPLHTTELLLNDNELG 583
            .:.:..:.|  :.||:.|      ||..|.||.|.|||:...|.:.|..:||.||||.||:|:|.
Zfish   486 AKEQYYIPGSEDTRMNKDCNSKPVCPPKCRCEATVVDCSNLRLTKFPEHLPLSTTELRLNNNDLS 550

  Fly   584 RISSDGLFGRLPHLVKLELKRNQLTGIEPNAFEGASHIQE------------------------L 624
            .:.:.|||..|.||.|:.|..|::|.||..||||||.:.|                        |
Zfish   551 ILEATGLFRPLTHLKKINLSNNKITEIEDGAFEGASSVVELHLTANLLVSVRGGMFRGMDGLRML 615

  Fly   625 QLGENKIKEISNKMFLGLHQLKTLNLYDNQISCVMPGSFEHLNSLTSLNLASNPFNCNCHLAWFA 689
            .|..|.|:.:.|..|.||..::.|:|||||:|.:|||:|:.|.:|::|||.:|||:|:|.|:|..
Zfish   616 MLRNNHIRCVHNSSFSGLQNVRLLSLYDNQLSTIMPGAFDSLPNLSTLNLLANPFSCDCRLSWLG 680

  Fly   690 EWLRKKSLNGGAARCGAPSKVRDVQIKDLPHSEFKCSS---ENSEGCLGDGYCPPSCTCTGTVVR 751
            ||||.:.:..|..||..|:.:|::.::|:...:|.|..   |....|:....||..|||..:|||
Zfish   681 EWLRSRQIVTGNPRCQNPAFLREIPLQDVAKPDFICDKDVLEQDVSCIPKPQCPEQCTCVDSVVR 745

  Fly   752 CSRNQLKEIPRGIPAETSELYLESNEIEQIHYERIRHLRSLTRLDLSNNQITILSNYTFANLTKL 816
            ||...|..:|||:|...:||||:.|....|..| :...|.|..||||||:|:.|:|.:|.|:::|
Zfish   746 CSNKHLSALPRGVPLNVTELYLDGNVFVSIPQE-LSAFRQLQLLDLSNNKISSLTNTSFTNMSQL 809

  Fly   817 STLIISYNKLQCLQRHALSGLNNLRVLSLHGNRISMLPEGSFEDLKSLTHIALGSNPLYCDCGLK 881
            :|||:|||.|:|:......||::||:||||||.||.|.:..|.|..||:|:|:|:|||||||.|:
Zfish   810 TTLILSYNALRCIPPLVFGGLSSLRLLSLHGNNISELHQQIFRDAASLSHLAIGANPLYCDCRLR 874

  Fly   882 WFSDWIKLDYVEPGIARCAEPEQMKDKLILSTPSSSFVCRGRVRNDILAKCNACFEQPCQNQAQC 946
            |.|||:|..|.||||||||.|:.|:.||:|:||.::|.|.|.|...:..||:.|...|||||.:|
Zfish   875 WLSDWVKSGYKEPGIARCAGPQGMEGKLLLTTPGNTFQCTGPVDASVSGKCSPCSSNPCQNQGRC 939

  Fly   947 VALPQREYQCLCQPGYHGKHCEFMIDACYGNPCRNNATCTVLEEGR-FSCQCAPGYTGARCETNI 1010
            ...|..:|:|.|..||.|::||..|.||..|||.|..||...|..| |.|.|..|:.|..||.::
Zfish   940 HNDPLHQYKCSCPQGYKGRNCELSISACEANPCVNGGTCRPEESRRGFRCVCPLGFEGLFCELDV 1004

  Fly  1011 DDCLGEIKCQNNATCIDGVESYKCECQPGFSGEFCDT-KIQFCSPEFNPCANGAKCMDHFTHYSC 1074
            |||: :.:|.|...|:|||.:|.|.|...|||:.|:. :...|.|..|||..|:.|:...:...|
Zfish  1005 DDCV-DHQCVNGTICVDGVGNYSCVCAQPFSGQKCEEYEEDLCYPGQNPCQRGSTCIPTVSGPKC 1068

  Fly  1075 DCQAGFHGTNCTDNIDDCQNHMCQNGGTCVDGINDYQCRCPDDYTGKYCEGHNMISMMYPQTSPC 1139
            .|..||.|.:|:.:.::|:.|.||||..|||.:..|.|.||..|:|:.||.         ..|.|
Zfish  1069 ICPPGFVGDDCSVDYNECEGHYCQNGARCVDHVAGYTCVCPAGYSGRLCEA---------SVSAC 1124

  Fly  1140 QNHECKHGV-CFQPNAQGSDYLCRCHPGYTGKWCEYLTSISFVHNNSFVELEPLRTRPEA---NV 1200
            ...:|.:|. |.:.:...   :|:|.||:.|..||.|.|::|:..:|::.|  ||...::   |:
Zfish  1125 DLLQCVNGAPCEEISGTA---VCQCLPGFNGLRCEKLLSVNFIDRDSYLLL--LRDATQSTHNNI 1184

  Fly  1201 TIVFSSAEQNGILMYDGQDAHLAVELFNGRIRVSYDVGNHPVSTMYSFEMVADGKYHAVELLAIK 1265
            |:..|:||.||||:|:|.:.|:||||.:|.::|:||.|..|.||:||.|:|.||::|.|||:..:
Zfish  1185 TLQVSTAEDNGILLYNGVNEHIAVELHDGHVKVTYDAGRQPGSTIYSSEIVNDGQFHTVELVTYE 1249

  Fly  1266 KNFTLRVDRGLARSIINEGSNDYLKLTTPMFLGGLPVDPAQQAYKNWQIRNLTSFKGCMKEVWIN 1330
            :...|.:|.||..::.:.|....|....|:::||:|.:....:..:|...|.:||:||::.::||
Zfish  1250 RMVNLSIDGGLPTTLDSSGHIQPLTRDAPLYVGGMPENAKSLSSNHWPPVNGSSFQGCIRNLYIN 1314

  Fly  1331 HKLVDFGNAQRQQKITPGCALLE--------------------------GEQQEEEDDEQDFMDE 1369
            ::|.||...|.:..:.|||...:                          |:.          .|:
Zfish  1315 NELQDFTQTQMKPGVVPGCQACQELLCVNGLCQPDSAIGPVCHCQPGWGGKH----------CDQ 1369

  Fly  1370 TPHIKEEPVDPCLENKCRRGSRCVPNSNARD--GYQCKCKHGQRGRYCDQGEGST---------- 1422
            .........:||.::||..|. ||    |.|  .|:|:|..|..|:.|.|.:..|
Zfish  1370 ILLTAAAATNPCQKHKCVHGV-CV----AVDLQSYRCECVEGFHGQLCSQQDPCTALSCQHGLCQ 1429

  Fly  1423 -----EPPTV----------TAASTCRKEQVREYYT----ENDCRSRQPLKYAKCVGGC---GNQ 1465
                 :|..|          ...|.|:.|.||:::.    :..|||..|:.:.:|.|||   ...
Zfish  1430 ISPTGQPQCVCDSGYSGQLCDIVSPCQGEPVRDFHRVQRGDVQCRSTLPMSWTECRGGCRADSGL 1494

  Fly  1466 CCAAKIVRRRKVRMVCSNNRKYIKNLDIVRKCGCTK 1501
            ||....||||:....|.:...:.:.::...:|||.|
Zfish  1495 CCVGLRVRRRRYGFECDDGTTFTQEVEKTVECGCGK 1530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sli	NP_001261017.1	LRRNT	73..103	CDD:214470	15/29 (52%)
		leucine-rich repeat	83..104	CDD:275380	8/20 (40%)
		LRR_8	102..160	CDD:290566	32/57 (56%)
		leucine-rich repeat	105..125	CDD:275380	10/19 (53%)
		LRR_RI	<119..259	CDD:238064	64/139 (46%)
		leucine-rich repeat	126..149	CDD:275380	13/22 (59%)
		LRR_8	149..208	CDD:290566	28/58 (48%)
		leucine-rich repeat	150..173	CDD:275380	11/22 (50%)
		leucine-rich repeat	174..197	CDD:275380	12/22 (55%)
		LRR_8	197..256	CDD:290566	25/58 (43%)
		leucine-rich repeat	198..221	CDD:275380	9/22 (41%)
		leucine-rich repeat	222..245	CDD:275380	11/22 (50%)
		leucine-rich repeat	246..371	CDD:275380	61/125 (49%)
		LRRCT	254..303	CDD:214507	23/48 (48%)
		LRRNT	319..350	CDD:214470	14/30 (47%)
		LRR_8	349..406	CDD:290566	38/56 (68%)
		LRR_4	371..411	CDD:289563	29/39 (74%)
		leucine-rich repeat	372..395	CDD:275380	17/22 (77%)
		leucine-rich repeat	396..415	CDD:275380	14/18 (78%)
		leucine-rich repeat	420..443	CDD:275380	14/22 (64%)
		leucine-rich repeat	444..465	CDD:275380	16/20 (80%)
		leucine-rich repeat	468..480	CDD:275378	8/11 (73%)
		LRRCT	476..525	CDD:214507	29/48 (60%)
		leucine-rich repeat	484..545	CDD:275380	30/68 (44%)
		LRRNT	542..574	CDD:214470	15/37 (41%)
		leucine-rich repeat	552..570	CDD:275380	6/17 (35%)
		leucine-rich repeat	572..596	CDD:275380	12/23 (52%)
		LRR_RI	<574..>678	CDD:238064	49/127 (39%)
		LRR_8	595..655	CDD:290566	28/83 (34%)
		leucine-rich repeat	597..620	CDD:275380	12/22 (55%)
		leucine-rich repeat	621..644	CDD:275380	9/46 (20%)
		leucine-rich repeat	645..668	CDD:275380	12/22 (55%)
		leucine-rich repeat	669..756	CDD:275380	35/89 (39%)
		LRRCT	677..726	CDD:214507	18/48 (38%)
		LRRNT	739..770	CDD:214470	15/30 (50%)
		leucine-rich repeat	757..791	CDD:275380	12/33 (36%)
		LRR_4	770..807	CDD:289563	17/36 (47%)
		LRR_8	790..850	CDD:290566	32/59 (54%)
		LRR_4	791..830	CDD:289563	21/38 (55%)
		leucine-rich repeat	792..815	CDD:275380	12/22 (55%)
		LRR_4	814..863	CDD:289563	24/48 (50%)
		leucine-rich repeat	816..839	CDD:275380	11/22 (50%)
		leucine-rich repeat	840..861	CDD:275380	12/20 (60%)
		LRRCT	872..920	CDD:214507	30/47 (64%)
		EGF	935..966	CDD:278437	14/30 (47%)
		EGF_CA	971..1007	CDD:238011	16/36 (44%)
		EGF_CA	1009..1045	CDD:238011	15/35 (43%)
		EGF_CA	1055..1086	CDD:238011	10/30 (33%)
		EGF_CA	1088..1124	CDD:238011	15/35 (43%)
		Laminin_G_1	1204..1335	CDD:278483	51/130 (39%)
		CT	1435..1504	CDD:214482	22/74 (30%)
slit1b	NP_001030147.1	LRR_8	306..365	CDD:290566	38/58 (66%)
		LRR_4	329..369	CDD:289563	28/39 (72%)
		leucine-rich repeat	331..354	CDD:275380	17/22 (77%)
		LRR_8	353..437	CDD:290566	55/83 (66%)
		leucine-rich repeat	355..375	CDD:275380	15/19 (79%)
		leucine-rich repeat	403..426	CDD:275380	16/22 (73%)
		leucine-rich repeat	427..482	CDD:275380	33/54 (61%)
		TPKR_C2	435..>465	CDD:301599	22/29 (76%)
		LRR_RI	<511..625	CDD:238064	43/113 (38%)
		leucine-rich repeat	519..538	CDD:275380	7/18 (39%)
		leucine-rich repeat	539..563	CDD:275380	12/23 (52%)
		LRR_8	562..622	CDD:290566	18/59 (31%)
		leucine-rich repeat	564..587	CDD:275380	12/22 (55%)
		leucine-rich repeat	588..611	CDD:275380	1/22 (5%)
		LRR_8	611..670	CDD:290566	25/58 (43%)
		leucine-rich repeat	612..635	CDD:275380	8/22 (36%)
		leucine-rich repeat	636..659	CDD:275380	12/22 (55%)
		leucine-rich repeat	660..753	CDD:275380	36/92 (39%)
		LRRCT	668..717	CDD:214507	18/48 (38%)
		LRRNT	732..764	CDD:214470	15/31 (48%)
		leucine-rich repeat	754..784	CDD:275380	11/30 (37%)
		LRR_8	783..843	CDD:290566	32/59 (54%)
		LRR_4	784..825	CDD:289563	21/40 (53%)
		leucine-rich repeat	785..808	CDD:275380	12/22 (55%)
		leucine-rich repeat	809..829	CDD:275380	9/19 (47%)
		leucine-rich repeat	833..856	CDD:275380	13/22 (59%)
		LRRCT	865..914	CDD:214507	30/48 (63%)
		EGF_CA	929..961	CDD:238011	13/31 (42%)
		EGF_CA	968..1001	CDD:238011	13/32 (41%)
		EGF_CA	1003..1039	CDD:238011	15/36 (42%)
		EGF_CA	<1051..1079	CDD:238011	10/27 (37%)
		LRRNT	30..61	CDD:214470	15/29 (52%)
		leucine-rich repeat	41..58	CDD:275380	8/16 (50%)
		leucine-rich repeat	60..83	CDD:275380	12/22 (55%)
		LRR_8	61..118	CDD:290566	32/56 (57%)
		LRR_4	61..98	CDD:289563	20/36 (56%)
		LRR_RI	<84..217	CDD:238064	61/132 (46%)
		leucine-rich repeat	84..107	CDD:275380	13/22 (59%)
		leucine-rich repeat	108..131	CDD:275380	11/22 (50%)
		LRR_8	130..190	CDD:290566	29/59 (49%)
		leucine-rich repeat	132..155	CDD:275380	12/22 (55%)
		leucine-rich repeat	156..179	CDD:275380	9/22 (41%)
		leucine-rich repeat	180..203	CDD:275380	11/22 (50%)
		leucine-rich repeat	204..247	CDD:275380	22/42 (52%)
		LRRCT	212..260	CDD:214507	23/47 (49%)
		leucine-rich repeat	248..330	CDD:275380	38/81 (47%)
		LRRNT	278..309	CDD:214470	14/30 (47%)
		EGF_CA	1082..1118	CDD:238011	15/35 (43%)
		LamG	1160..1314	CDD:238058	56/155 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	111	1.000	Domainoid score	I6186
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1305	1.000	Inparanoid score	I151
OMA	1	1.010	-	-		QHG45950
OrthoDB	1	1.010	-	-		D20003at33208
OrthoFinder	1	1.000	-	-		FOG0001593
OrthoInspector	1	1.000	-	-		otm24689
orthoMCL	1	0.900	-	-		OOG6_103623
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1145
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.880