DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sli and rtn4rl2a

DIOPT Version :9

Sequence 1:	NP_001261017.1	Gene:	sli / 36746	FlyBaseID:	FBgn0264089	Length:	2157	Species:	Drosophila melanogaster
Sequence 2:	NP_982346.1	Gene:	rtn4rl2a / 403307	ZFINID:	ZDB-GENE-040310-4	Length:	458	Species:	Danio rerio

Alignment Length:	452	Identity:	98/452 - (21%)
Similarity:	149/452 - (32%)	Gaps:	177/452 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 CPRVCSC--TGLNVDCSHRGLTSVPRKISADVERLELQGNNLTVIYETDFQRLTKLRMLQLTDNQ 135
            ||..|.|  |.:.|.|..:..|.||..:..:.:|:.||.|.:|.:....|...|  ::|.|..|.
Zfish    41 CPHRCVCYPTPMTVSCQAQNFTIVPHGMPYESQRVFLQNNRITELRVGSFAFGT--QVLWLFSNN 103

  Fly   136 IHTIERNSFQDLVSLERLRLNNNRLKAIPENFVTSSASLLRLDISNNVITTVGRRVFKGAQSLRS 200
            |..||..:|.:|..||.|.|.
Zfish   104 ITWIEAGAFSELRDLEELDLG-------------------------------------------- 124

  Fly   201 LQLDNNQITCLDEHAFKGLVELEILTLNNNNLTSLPHNIFGGLGRLRALRLSDNPFACDCHLSWL 265
               ||..:..|:..||:||.:|:.|.::...|.:|||:||..|..|:.|.|.:|
Zfish   125 ---DNPNLHRLEGGAFRGLEKLQSLHMHRCKLAALPHDIFHKLYSLQFLYLQEN----------- 175

  Fly   266 SRFLRSATRLAPYTRCQSPSQLKGQNVADLHDQEFKCSGLTEHAPMECGAENSCPHPCRCADGIV 330
                                        .||
Zfish   176 ----------------------------QLH---------------------------------- 178

  Fly   331 DCREKSLTSVPVTLPDDTTELRLEQNFITELPPKSFSSFRRLRRIDLSNNNISRIAHDALSGLKQ 395
                                      ||.:                           |..:.|..
Zfish   179 --------------------------FIQD---------------------------DLFADLIN 190

  Fly   396 LTTLVLYGNKIKDLPSGVFKGLGSLQLLLLNANEISCIRKDAFRDLHSLSLLSLYDNNIQSLANG 460
            |:.|.|:||:|:.|...||:||.:|..|||:.|.:..:.:.|||||..|::|.|::|::..|...
Zfish   191 LSQLFLHGNRIRTLSENVFRGLVNLDRLLLHDNRVRQVNRRAFRDLGQLTMLFLFNNSLAELPGQ 255

  Fly   461 TFDAMKSIKTVHLAKNPFICDCNLRWLADYLHKNPIETSGARCESPKRMHRRRIESLREEKF 522
            ....:.||:.:.|..||:.|.|..|.|.::.....:.:|...|.||.....:.:..|||..|
Zfish   256 AMRDVSSIEFLRLNNNPWACGCEARPLWEFFRGARLSSSEVLCASPASRRGQDLRFLREMDF 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sli	NP_001261017.1	LRRNT	73..103	CDD:214470	10/31 (32%)
		leucine-rich repeat	83..104	CDD:275380	5/20 (25%)
		LRR_8	102..160	CDD:290566	19/57 (33%)
		leucine-rich repeat	105..125	CDD:275380	5/19 (26%)
		LRR_RI	<119..259	CDD:238064	34/139 (24%)
		leucine-rich repeat	126..149	CDD:275380	8/22 (36%)
		LRR_8	149..208	CDD:290566	6/58 (10%)
		leucine-rich repeat	150..173	CDD:275380	4/22 (18%)
		leucine-rich repeat	174..197	CDD:275380	0/22 (0%)
		LRR_8	197..256	CDD:290566	20/58 (34%)
		leucine-rich repeat	198..221	CDD:275380	7/22 (32%)
		leucine-rich repeat	222..245	CDD:275380	9/22 (41%)
		leucine-rich repeat	246..371	CDD:275380	8/124 (6%)
		LRRCT	254..303	CDD:214507	3/48 (6%)
		LRRNT	319..350	CDD:214470	0/30 (0%)
		LRR_8	349..406	CDD:290566	9/56 (16%)
		LRR_4	371..411	CDD:289563	9/39 (23%)
		leucine-rich repeat	372..395	CDD:275380	2/22 (9%)
		leucine-rich repeat	396..415	CDD:275380	8/18 (44%)
		leucine-rich repeat	420..443	CDD:275380	10/22 (45%)
		leucine-rich repeat	444..465	CDD:275380	5/20 (25%)
		leucine-rich repeat	468..480	CDD:275378	4/11 (36%)
		LRRCT	476..525	CDD:214507	14/47 (30%)
		leucine-rich repeat	484..545	CDD:275380	10/39 (26%)
		LRRNT	542..574	CDD:214470
		leucine-rich repeat	552..570	CDD:275380
		leucine-rich repeat	572..596	CDD:275380
		LRR_RI	<574..>678	CDD:238064
		LRR_8	595..655	CDD:290566
		leucine-rich repeat	597..620	CDD:275380
		leucine-rich repeat	621..644	CDD:275380
		leucine-rich repeat	645..668	CDD:275380
		leucine-rich repeat	669..756	CDD:275380
		LRRCT	677..726	CDD:214507
		LRRNT	739..770	CDD:214470
		leucine-rich repeat	757..791	CDD:275380
		LRR_4	770..807	CDD:289563
		LRR_8	790..850	CDD:290566
		LRR_4	791..830	CDD:289563
		leucine-rich repeat	792..815	CDD:275380
		LRR_4	814..863	CDD:289563
		leucine-rich repeat	816..839	CDD:275380
		leucine-rich repeat	840..861	CDD:275380
		LRRCT	872..920	CDD:214507
		EGF	935..966	CDD:278437
		EGF_CA	971..1007	CDD:238011
		EGF_CA	1009..1045	CDD:238011
		EGF_CA	1055..1086	CDD:238011
		EGF_CA	1088..1124	CDD:238011
		Laminin_G_1	1204..1335	CDD:278483
		CT	1435..1504	CDD:214482
rtn4rl2a	NP_982346.1	leucine-rich repeat	53..70	CDD:275380	5/16 (31%)
		LRR_8	73..127	CDD:290566	20/102 (20%)
		leucine-rich repeat	73..93	CDD:275380	6/19 (32%)
		LRR_RI	94..>329	CDD:238064	82/399 (21%)
		leucine-rich repeat	95..117	CDD:275380	8/21 (38%)
		leucine-rich repeat	118..142	CDD:275380	11/70 (16%)
		leucine-rich repeat	143..166	CDD:275380	9/22 (41%)
		LRR_8	166..225	CDD:290566	26/184 (14%)
		leucine-rich repeat	167..190	CDD:275380	10/148 (7%)
		leucine-rich repeat	191..214	CDD:275380	11/22 (50%)
		LRR_8	214..272	CDD:290566	18/57 (32%)
		leucine-rich repeat	215..238	CDD:275380	10/22 (45%)
		leucine-rich repeat	239..262	CDD:275380	5/22 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910