DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sli and chad

DIOPT Version :9

Sequence 1:	NP_001261017.1	Gene:	sli / 36746	FlyBaseID:	FBgn0264089	Length:	2157	Species:	Drosophila melanogaster
Sequence 2:	NP_957357.1	Gene:	chad / 394038	ZFINID:	ZDB-GENE-040426-1130	Length:	363	Species:	Danio rerio

Alignment Length:	416	Identity:	104/416 - (25%)
Similarity:	161/416 - (38%)	Gaps:	116/416 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   541 SDCPAMCHCEGTT--VDCTGRGLKEIPRDIPLHTTELLLNDNELGRISSDGLFGRLPHLVKLELK 603
            :.||:.|||.|..  |.|...|||:||| |...|..|.|..|.||.:.:.| |..:..|:.|
Zfish    25 TQCPSQCHCHGDLQHVICDNVGLKKIPR-ISEATRLLNLQRNNLGNLPTGG-FSEMKGLISL--- 84

  Fly   604 RNQLTGIEPNAFEGASHIQELQLGENKIKEISNKMFLGLHQLKTLNLYDNQISCVMPGSFEHLNS 668
                            |:|..|     |:|:|.:.|.||::|..|.|.||:||.:.||:||.|..
Zfish    85 ----------------HLQHCQ-----IRELSGQAFKGLNKLIYLYLSDNEISTIKPGAFEDLTE 128

  Fly   669 LTSLNLASNPFNCNCHLAWFAEWLRKKSLNGGAARCGAPSKVRDVQIKDLPHSEFKCSSENSEGC 733
            ||.|.|..|                                    ||..||...|
Zfish   129 LTYLYLDGN------------------------------------QITSLPKGIF---------- 147

  Fly   734 LGDGYCPPSCTCTGTVVRCSRNQLKEIPRGI---PAETSELYLESNEIEQIH---YERIRHLRSL 792
                    |......:::.:.|:|:|:..|.   ..:...||:..||:..|.   .:.:.:|..|
Zfish   148 --------SPMINLFILQLNNNKLRELQPGTFKGAKDLRWLYMSGNELSSIQPGSLDEVENLAIL 204

  Fly   793 T---------------------RLDLSNNQITILSNYTFANLTK-LSTLIISYNKLQCLQRHALS 835
            |                     .|:||.|.::::.::.|.:..: :..|.::...|:.....|..
Zfish   205 TLDQNNLSTYPLLAMSKLRVVEELNLSKNPLSLIPDHAFRSFGRYMEKLHLNDMSLEKFSNAAFE 269

  Fly   836 GLNNLRVLSLHGNRISMLPEGSFEDLKSLTHIALGSNPLYCDCGLKWFSDWIKLDYVEPGIARCA 900
            |:..|:.|.|..|::..||...  :..::.:|.|.:||..|.|.|.....|:......|. |.||
Zfish   270 GVTALKSLHLENNKLRSLPNSL--EFSTIQNITLFNNPWSCTCPLTNLRKWMDTTRNRPD-AVCA 331

  Fly   901 EPEQMKDKLILSTPSSSFV-CRGRVR 925
            .|...|.|.|  ..|::|. |:|:.:
Zfish   332 SPANQKGKQI--RDSTAFTRCKGKTK 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sli	NP_001261017.1	LRRNT	73..103	CDD:214470
		leucine-rich repeat	83..104	CDD:275380
		LRR_8	102..160	CDD:290566
		leucine-rich repeat	105..125	CDD:275380
		LRR_RI	<119..259	CDD:238064
		leucine-rich repeat	126..149	CDD:275380
		LRR_8	149..208	CDD:290566
		leucine-rich repeat	150..173	CDD:275380
		leucine-rich repeat	174..197	CDD:275380
		LRR_8	197..256	CDD:290566
		leucine-rich repeat	198..221	CDD:275380
		leucine-rich repeat	222..245	CDD:275380
		leucine-rich repeat	246..371	CDD:275380
		LRRCT	254..303	CDD:214507
		LRRNT	319..350	CDD:214470
		LRR_8	349..406	CDD:290566
		LRR_4	371..411	CDD:289563
		leucine-rich repeat	372..395	CDD:275380
		leucine-rich repeat	396..415	CDD:275380
		leucine-rich repeat	420..443	CDD:275380
		leucine-rich repeat	444..465	CDD:275380
		leucine-rich repeat	468..480	CDD:275378
		LRRCT	476..525	CDD:214507
		leucine-rich repeat	484..545	CDD:275380	1/3 (33%)
		LRRNT	542..574	CDD:214470	16/33 (48%)
		leucine-rich repeat	552..570	CDD:275380	9/19 (47%)
		leucine-rich repeat	572..596	CDD:275380	8/23 (35%)
		LRR_RI	<574..>678	CDD:238064	34/103 (33%)
		LRR_8	595..655	CDD:290566	16/59 (27%)
		leucine-rich repeat	597..620	CDD:275380	2/22 (9%)
		leucine-rich repeat	621..644	CDD:275380	8/22 (36%)
		leucine-rich repeat	645..668	CDD:275380	12/22 (55%)
		leucine-rich repeat	669..756	CDD:275380	11/86 (13%)
		LRRCT	677..726	CDD:214507	6/48 (13%)
		LRRNT	739..770	CDD:214470	5/33 (15%)
		leucine-rich repeat	757..791	CDD:275380	9/39 (23%)
		LRR_4	770..807	CDD:289563	12/60 (20%)
		LRR_8	790..850	CDD:290566	15/81 (19%)
		LRR_4	791..830	CDD:289563	9/60 (15%)
		leucine-rich repeat	792..815	CDD:275380	7/43 (16%)
		LRR_4	814..863	CDD:289563	10/49 (20%)
		leucine-rich repeat	816..839	CDD:275380	4/22 (18%)
		leucine-rich repeat	840..861	CDD:275380	6/20 (30%)
		LRRCT	872..920	CDD:214507	16/48 (33%)
		EGF	935..966	CDD:278437
		EGF_CA	971..1007	CDD:238011
		EGF_CA	1009..1045	CDD:238011
		EGF_CA	1055..1086	CDD:238011
		EGF_CA	1088..1124	CDD:238011
		Laminin_G_1	1204..1335	CDD:278483
		CT	1435..1504	CDD:214482
chad	NP_957357.1	LRRNT	26..52	CDD:279764	12/25 (48%)
		leucine-rich repeat	57..80	CDD:275380	8/23 (35%)
		LRR_8	79..139	CDD:290566	28/119 (24%)
		leucine-rich repeat	81..104	CDD:275380	11/46 (24%)
		LRR_RI	<96..304	CDD:238064	55/263 (21%)
		LRR_4	104..143	CDD:289563	19/74 (26%)
		leucine-rich repeat	105..128	CDD:275380	12/22 (55%)
		LRR_8	127..187	CDD:290566	18/113 (16%)
		leucine-rich repeat	129..152	CDD:275380	11/76 (14%)
		leucine-rich repeat	153..176	CDD:275380	4/22 (18%)
		LRR_8	177..235	CDD:290566	12/57 (21%)
		leucine-rich repeat	177..200	CDD:275380	5/22 (23%)
		leucine-rich repeat	201..224	CDD:275380	3/22 (14%)
		LRR_8	225..284	CDD:290566	13/58 (22%)
		leucine-rich repeat	225..248	CDD:275380	5/22 (23%)
		leucine-rich repeat	250..273	CDD:275380	4/22 (18%)
		LRRCT	304..351	CDD:214507	16/49 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45836
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010