Protein Alignment sli and lrfn1

DIOPT Version :10

• Sequence 1: NP_001261017.1
• Gene: sli / 36746
• FlyBaseID: FBgn0264089
• Length: 2157
• Species: Drosophila melanogaster
• Sequence 2: NP_956909.3
• Gene: lrfn1 / 393587
• ZFINID: ZDB-GENE-040426-1227
• Length: 742
• Species: Danio rerio
• Alignment Length: 656
• Identity: 143/656 - (21%)
• Similarity: 215/656 - (32%)
• Gaps: 241/656 - (36%)

  Fly    66 GVITEAR-CPRVCSC----TGLNVDCSHRGLTSVPRKISADVERLELQGNNLTVIYETDFQRLTK 125
            |.:.:|: ||..|.|    ..|.:.|:..||..||..:......|.|..|.:|.:...||..:|.
Zfish    12 GALAKAQLCPGRCICQTISPTLTLLCAKTGLLFVPPTVDRKTVELRLTDNFITAVRRKDFLNMTS 76

  Fly   126 LRMLQLTDNQIHTIERNSFQDLVSLERLRLNNNRLKAIPENFVTSSASLLRLDISNNVITTVGRR 190
            |..|.|:.|.|..|..::|..|.||..|.::.|||..|      :|..|
Zfish    77 LVHLTLSRNTISQIAPHAFMGLKSLRALHMDGNRLSVI------NSDQL---------------- 119

  Fly   191 VFKGAQSLRSLQLDNNQITCLDEHAFKGLV-ELEILTLNNNNLTSLP----------------HN 238
              ||..:||.|.|.||||..::|.:|...| .:|.|.|:.|||.:||                ||
Zfish   120 --KGLMNLRHLILGNNQIHHIEESSFDEFVATIEDLDLSYNNLRTLPWEAIARMTNINTLTLDHN 182

  Fly   239 IFGGLG------------------RLRAL---------------------RLS----DNPFACDC 260
            :...:|                  ||:.|                     ||:    .||..|:|
Zfish   183 LIDHIGVGTFTLLTKLVRLDMTSNRLQTLPPDTLFQHAQVLSEPKTSSSSRLTVSFGGNPLHCNC 247

  Fly   261 HLSWLSRFLRSATRLAPYTRCQSPSQLKGQNVADLHDQEFKCSG--LTEHAPMECGAENSCPHPC 323
            .|.||.|.    ||......|.||..|..:....:.::||.|..  :|:|       :.:.|:
Zfish   248 ELLWLRRL----TREDDLETCASPEHLMDKYFWSIQEEEFICEPPLITKH-------QVTKPY-- 299

  Fly   324 RCADGIVDCREKSLTSVPVTLPDDTTELRLEQNFITELPPKSFSSFRRLRRIDLSNNNISRIAHD 388
                 :::.:..:|....:..||.....|....                   .|.:||
Zfish   300 -----VMEGQGVTLKCKAMGDPDPAIHWRFPDG-------------------KLVHNN------- 333

  Fly   389 ALSGLKQLTTLVLYGNKIKDLPSGVFKGLGSLQLLLLNANEISCIRKDAFRDLHSLSLLSLYDNN 453
                    :..:||.|...|:.....|..|:...:..||..|:    .|...:|.:.|..|.:|
Zfish   334 --------SRTLLYDNGTLDILITTLKDSGAFNCVASNAAGIA----TAAVHVHMIPLPLLVNN- 385

  Fly   454 IQSLANGTFDAMKSIKTVHLAK-NPFICDCNLRWLADYLHKNPIETSGARCESPKRMHRRR--IE 515
                            |.|:.: :|.:.|              |.||.....:..:.|.:|  :|
Zfish   386 ----------------TGHMREADPGLSD--------------ISTSSRSSSNDSKTHSKRVLVE 420

  Fly   516 SLREEKFKCSWDELRMKLSGECRMDSDCPAMCHCEG---------TTVDCTGRGLKEIPRDIPLH 571
            :|........|                 |:..|..|         :|||.|     .:.|.||..
Zfish   421 NLTAHSAVIHW-----------------PSERHIPGIRMYQIQYNSTVDDT-----LVYRMIPSA 463

  Fly   572 TTELLLNDNELGR--------ISSDGL-------------FGRLPHLVKLELKRNQLTGIEPNAF 615
            :....:||...||        :..||:             |..||       :.||...: |:.|
Zfish   464 SKTFRINDLAAGREYELCVLAVYDDGITSLTATRVVGCVHFHTLP-------ETNQCRFV-PSQF 520

  Fly   616 EGASHI 621
            .|.:.|
Zfish   521 LGGTMI 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sli	NP_001261017.1	LRRNT	73..103	CDD:214470	10/33 (30%)
		leucine-rich repeat	83..104	CDD:275380	5/20 (25%)
		LRR	98..>409	CDD:443914	83/372 (22%)
		leucine-rich repeat	105..125	CDD:275380	6/19 (32%)
		leucine-rich repeat	126..149	CDD:275380	8/22 (36%)
		leucine-rich repeat	150..173	CDD:275380	7/22 (32%)
		leucine-rich repeat	174..197	CDD:275380	3/22 (14%)
		leucine-rich repeat	198..221	CDD:275380	11/23 (48%)
		leucine-rich repeat	222..245	CDD:275380	11/56 (20%)
		leucine-rich repeat	246..371	CDD:275380	28/151 (19%)
		LRRCT	254..303	CDD:214507	16/48 (33%)
		LRR	<329..>498	CDD:443914	26/169 (15%)
		leucine-rich repeat	372..395	CDD:275380	3/22 (14%)
		leucine-rich repeat	396..415	CDD:275380	4/18 (22%)
		leucine-rich repeat	420..443	CDD:275380	4/22 (18%)
		leucine-rich repeat	444..465	CDD:275380	3/20 (15%)
		leucine-rich repeat	468..480	CDD:275378	3/12 (25%)
		LRRCT	476..525	CDD:214507	9/50 (18%)
		leucine-rich repeat	484..545	CDD:275380	8/62 (13%)
		LRRNT	542..574	CDD:214470	10/40 (25%)
		leucine-rich repeat	552..570	CDD:275380	6/17 (35%)
		LRR	572..>874	CDD:443914	15/71 (21%)
		leucine-rich repeat	572..596	CDD:275380	8/44 (18%)
		leucine-rich repeat	597..620	CDD:275380	5/22 (23%)
		leucine-rich repeat	621..644	CDD:275380	1/1 (100%)
		leucine-rich repeat	645..668	CDD:275380
		leucine-rich repeat	669..756	CDD:275380
		LRRCT	677..726	CDD:214507
		leucine-rich repeat	757..791	CDD:275380
		leucine-rich repeat	792..815	CDD:275380
		leucine-rich repeat	816..839	CDD:275380
		leucine-rich repeat	840..861	CDD:275380
		PCC	845..>986	CDD:188093
		EGF_CA	971..1007	CDD:238011
		EGF_CA	1009..1045	CDD:238011
		EGF_CA	1055..1086	CDD:238011
		EGF_CA	1088..1124	CDD:238011
		Laminin_G_1	1204..1335	CDD:395008
		CT	1435..1504	CDD:214482
lrfn1	NP_956909.3	None