DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sli and Slit2

DIOPT Version :9

Sequence 1:	NP_001261017.1	Gene:	sli / 36746	FlyBaseID:	FBgn0264089	Length:	2157	Species:	Drosophila melanogaster
Sequence 2:	XP_017454764.1	Gene:	Slit2 / 360272	RGDID:	69310	Length:	1542	Species:	Rattus norvegicus

Alignment Length:	1526	Identity:	680/1526 - (44%)
Similarity:	947/1526 - (62%)	Gaps:	111/1526 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 CPRVCSCTGLNVDCSHRGLTSVPRKISADVERLELQGNNLTVIYETDFQRLTKLRMLQLTDNQIH 137
            ||..|||:|..|||....|.||||.|..:.|||:|.|||:|.|.:|||..|..||:|||.:|:|.
  Rat    28 CPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKIS 92

  Fly   138 TIERNSFQDLVSLERLRLNNNRLKAIPENFVTSSASLLRLDISNNVITTVGRRVFKGAQSLRSLQ 202
            ||||.:||||..|||||||.|.|:..||.....:|.|.|||:|.|.|..:.|:.|:||..:::||
  Rat    93 TIERGAFQDLKELERLRLNRNNLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQ 157

  Fly   203 LDNNQITCLDEHAFKGLVELEILTLNNNNLTSLPHNIFGGLGRLRALRLSDNPFACDCHLSWLSR 267
            ||.|||:|:::.||:.|.:||:|||||||:|.|....|..:.:||..||..|...|||||:|||.
  Rat   158 LDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSD 222

  Fly   268 FLRSATRLAPYTRCQSPSQLKGQNVADLHDQEFKCSGLTE-H----APMECGAENSCPHPCRCAD 327
            :||...|:..||:|..||.|:|.|||::..:||.||...| |    || .|...: ||..|.|::
  Rat   223 WLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSDEEEGHQSFMAP-SCSVLH-CPIACTCSN 285

  Fly   328 GIVDCREKSLTSVPVTLPDDTTELRLEQNFITELPPKSFSSFRRLRRIDLSNNNISRIAHDALSG 392
            .|||||.|.||.:|..||:..||:|||||.|..:||.:||.:::|||:|||||.||.:|.||..|
  Rat   286 NIVDCRGKGLTEIPTNLPETITEIRLEQNSIRVIPPGAFSPYKKLRRLDLSNNQISELAPDAFQG 350

  Fly   393 LKQLTTLVLYGNKIKDLPSGVFKGLGSLQLLLLNANEISCIRKDAFRDLHSLSLLSLYDNNIQSL 457
            |:.|.:||||||||.:||..:|:||.||||||||||:|:|:|.|||:|||:|:|||||||.:|::
  Rat   351 LRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTV 415

  Fly   458 ANGTFDAMKSIKTVHLAKNPFICDCNLRWLADYLHKNPIETSGARCESPKRMHRRRIESLREEKF 522
            |.|||.|:::|:|:|||:|||||||:|:|||||||.||||||||||.||:|:..:||..::.:||
  Rat   416 AKGTFSALRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKF 480

  Fly   523 KCS---------WDELRMKLSGECRMDSDCPAMCHCEGTTVDCTGRGLKEIPRDIPLHTTELLLN 578
            :||         .::.|.||||:|..|..||..|.||||||||:.:.|.:||..||.:|.||.||
  Rat   481 RCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPDHIPQYTAELRLN 545

  Fly   579 DNELGRISSDGLFGRLPHLVKLELKRNQLTGIEPNAFEGASHIQELQLGENKIKEISNKMFLGLH 643
            :||...:.:.|:|.:||.|.|:.|..|::|.||..||||||.:.|:.|..|:::.:.:|||.||.
  Rat   546 NNEFTVLEATGIFKKLPQLRKINLSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLE 610

  Fly   644 QLKT------------------------LNLYDNQISCVMPGSFEHLNSLTSLNLASNPFNCNCH 684
            .|||                        |:||||||:.|.||:|..|:||::|||.:||||||||
  Rat   611 SLKTLMLRSNRISCVGNDSFTGLGSVRLLSLYDNQITTVAPGAFGTLHSLSTLNLLANPFNCNCH 675

  Fly   685 LAWFAEWLRKKSLNGGAARCGAPSKVRDVQIKDLPHSEFKCSSENSE-GCLGDGYCPPSCTCTGT 748
            |||..||||:|.:..|..||..|..::::.|:|:...:|.|...|.: .|.....||..|||..|
  Rat   676 LAWLGEWLRRKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPSECTCLDT 740

  Fly   749 VVRCSRNQLKEIPRGIPAETSELYLESNEIEQIHYERIRHLRSLTRLDLSNNQITILSNYTFANL 813
            |||||...||.:|:|||.:.:||||:.|:...:..| :.:.:.||.:|||||:|:.|||.:|:|:
  Rat   741 VVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKE-LSNYKHLTLIDLSNNRISTLSNQSFSNM 804

  Fly   814 TKLSTLIISYNKLQCLQRHALSGLNNLRVLSLHGNRISMLPEGSFEDLKSLTHIALGSNPLYCDC 878
            |:|.|||:|||:|:|:......||.:||:||||||.||::|||:|.||.:|:|:|:|:|||||||
  Rat   805 TQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFGDLSALSHLAIGANPLYCDC 869

  Fly   879 GLKWFSDWIKLDYVEPGIARCAEPEQMKDKLILSTPSSSFVCRGRVRNDILAKCNACFEQPCQNQ 943
            .::|.|||:|.:|.||||||||.|.:|.|||:|:|||..|.|:|.|...|.||||.|...||:|.
  Rat   870 NMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPVDVTIQAKCNPCLSNPCKND 934

  Fly   944 AQCVALPQREYQCLCQPGYHGKHCEFMIDACYGNPCRNNATCTVLEEGR---FSCQCAPGYTGAR 1005
            ..|...|...|:|.|..|:.|:.|:..|.||..|||::..||. |:||.   |.|.||.|:.|..
  Rat   935 GTCNNDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCH-LKEGENDGFWCTCADGFEGES 998

  Fly  1006 CETNIDDCLGEIKCQNNATCIDGVESYKCECQPGFS---------GEFCDTKIQFCSPEFNPCAN 1061
            |:.||||| .:..|:||:||:||:.:|.|.|.|.::         ||.|:.|:.||:.:.|||.:
  Rat   999 CDINIDDC-EDNDCENNSTCVDGINNYTCLCPPEYTAANLNEVEKGELCEEKLDFCAQDLNPCQH 1062

  Fly  1062 GAKCMDHFTHYSCDCQAGFHGTNCTDNIDDCQNHMCQNGGTCVDGINDYQCRCPDDYTGKYCEGH 1126
            .:||:.....:.|||..|:.|.:|..:.||||::.|:||..|.|.:|.|.|.||:.|:|.:||..
  Rat  1063 DSKCILTPKGFKCDCTPGYIGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCVCPEGYSGLFCEFS 1127

  Fly  1127 NMISMMYPQTSPCQNHECKHGVCFQPNAQGSDYLCRCHPGYTGKWCEYLTSISFVHNNSFVELEP 1191
            .  .|:.|:||||.|.:|::|.  |...:.::.:|:|.|||.|:.||.|.|::||:..|::::..
  Rat  1128 P--PMVLPRTSPCDNFDCQNGA--QCIIRVNEPICQCLPGYLGEKCEKLVSVNFVNKESYLQIPS 1188

  Fly  1192 LRTRPEANVTIVFSSAEQNGILMYDGQDAHLAVELFNGRIRVSYDVGNHPVSTMYSFEMVADGKY 1256
            .:.||:.|:|:..::.|.:|||:|.|...|:||||:.||:|.|||.|:||.|.:||.|.:.||.:
  Rat  1189 AKVRPQTNITLQIATDEDSGILLYKGDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNF 1253

  Fly  1257 HAVELLAIKKNFTLRVDRGLARSIINEGSNDYLKLTTPMFLGGLPVDPAQQAYKNWQIRNLTSFK 1321
            |.||||.:..:.:|.||.|..:.|.|......|...:|:::||:|......:.:....:|.|||.
  Rat  1254 HIVELLTLDSSLSLSVDGGSPKIITNLSKQSTLNFDSPLYVGGMPGKNNVASLRQAPGQNGTSFH 1318

  Fly  1322 GCMKEVWINHKLVDFGNAQRQQKITPGC------ALLEGEQQEEEDD------EQDFMDETPHIK 1374
            ||::.::||.:|.||.....|..|.|||      ....|..|.....      |:.:|.  |...
  Rat  1319 GCIRNLYINSELQDFRKVPMQTGILPGCEPCHKKVCAHGTCQPSSQSGFTCECEEGWMG--PLCD 1381

  Fly  1375 EEPVDPCLENKCRRGSRCVPNSNARDGYQCKCKHGQRGRYCDQGEGSTEP--------------- 1424
            :...||||.|||..|: |:| .|| ..|.|||..|..|..||:.|....|
  Rat  1382 QRTNDPCLGNKCVHGT-CLP-INA-FSYSCKCLEGHGGVLCDEEEDLFNPCQVIKCKHGKCRLSG 1443

  Fly  1425 ---PTVTAAS-----------TCRKEQVREYYTEND----CRSRQPLKYAKCVGGC-GNQCCAAK 1470
               |....:|           :||.|::|:||.:..    |::.:.:...:|.||| |.|||...
  Rat  1444 LGQPYCECSSGFTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPL 1508

  Fly  1471 IVRRRKVRMVCSNNRKYIKNLDIVRKCGCTK 1501
            ..:|||....|::...::..::.|.|||||:
  Rat  1509 RSKRRKYSFECTDGSSFVDEVEKVVKCGCTR 1539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sli	NP_001261017.1	LRRNT	73..103	CDD:214470	15/29 (52%)
		leucine-rich repeat	83..104	CDD:275380	9/20 (45%)
		LRR_8	102..160	CDD:290566	36/57 (63%)
		leucine-rich repeat	105..125	CDD:275380	11/19 (58%)
		LRR_RI	<119..259	CDD:238064	69/139 (50%)
		leucine-rich repeat	126..149	CDD:275380	15/22 (68%)
		LRR_8	149..208	CDD:290566	28/58 (48%)
		leucine-rich repeat	150..173	CDD:275380	11/22 (50%)
		leucine-rich repeat	174..197	CDD:275380	11/22 (50%)
		LRR_8	197..256	CDD:290566	28/58 (48%)
		leucine-rich repeat	198..221	CDD:275380	11/22 (50%)
		leucine-rich repeat	222..245	CDD:275380	12/22 (55%)
		leucine-rich repeat	246..371	CDD:275380	62/129 (48%)
		LRRCT	254..303	CDD:214507	24/48 (50%)
		LRRNT	319..350	CDD:214470	15/30 (50%)
		LRR_8	349..406	CDD:290566	34/56 (61%)
		LRR_4	371..411	CDD:289563	25/39 (64%)
		leucine-rich repeat	372..395	CDD:275380	15/22 (68%)
		leucine-rich repeat	396..415	CDD:275380	11/18 (61%)
		leucine-rich repeat	420..443	CDD:275380	17/22 (77%)
		leucine-rich repeat	444..465	CDD:275380	13/20 (65%)
		leucine-rich repeat	468..480	CDD:275378	8/11 (73%)
		LRRCT	476..525	CDD:214507	32/48 (67%)
		leucine-rich repeat	484..545	CDD:275380	35/69 (51%)
		LRRNT	542..574	CDD:214470	17/31 (55%)
		leucine-rich repeat	552..570	CDD:275380	9/17 (53%)
		leucine-rich repeat	572..596	CDD:275380	10/23 (43%)
		LRR_RI	<574..>678	CDD:238064	51/127 (40%)
		LRR_8	595..655	CDD:290566	30/83 (36%)
		leucine-rich repeat	597..620	CDD:275380	12/22 (55%)
		leucine-rich repeat	621..644	CDD:275380	8/22 (36%)
		leucine-rich repeat	645..668	CDD:275380	15/46 (33%)
		leucine-rich repeat	669..756	CDD:275380	41/87 (47%)
		LRRCT	677..726	CDD:214507	23/48 (48%)
		LRRNT	739..770	CDD:214470	17/30 (57%)
		leucine-rich repeat	757..791	CDD:275380	12/33 (36%)
		LRR_4	770..807	CDD:289563	15/36 (42%)
		LRR_8	790..850	CDD:290566	33/59 (56%)
		LRR_4	791..830	CDD:289563	23/38 (61%)
		leucine-rich repeat	792..815	CDD:275380	13/22 (59%)
		LRR_4	814..863	CDD:289563	28/48 (58%)
		leucine-rich repeat	816..839	CDD:275380	11/22 (50%)
		leucine-rich repeat	840..861	CDD:275380	14/20 (70%)
		LRRCT	872..920	CDD:214507	31/47 (66%)
		EGF	935..966	CDD:278437	11/30 (37%)
		EGF_CA	971..1007	CDD:238011	17/38 (45%)
		EGF_CA	1009..1045	CDD:238011	18/44 (41%)
		EGF_CA	1055..1086	CDD:238011	10/30 (33%)
		EGF_CA	1088..1124	CDD:238011	16/35 (46%)
		Laminin_G_1	1204..1335	CDD:278483	51/130 (39%)
		CT	1435..1504	CDD:214482	23/72 (32%)
Slit2	XP_017454764.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I11669
eggNOG	1	0.900	-	-		E2759_KOG4237
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H3516
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D20003at33208
OrthoFinder	1	1.000	-	-		FOG0001593
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103623
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.680