DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sli and Lrtm1

DIOPT Version :9

Sequence 1:	NP_001261017.1	Gene:	sli / 36746	FlyBaseID:	FBgn0264089	Length:	2157	Species:	Drosophila melanogaster
Sequence 2:	NP_795894.1	Gene:	Lrtm1 / 319476	MGIID:	2442106	Length:	356	Species:	Mus musculus

Alignment Length:	215	Identity:	67/215 - (31%)
Similarity:	107/215 - (49%)	Gaps:	8/215 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 SCPHPCRC--ADGIVDCREKSLTSVPVTLPDDTTELRLEQNFITELPPKSFSSFRRLRRIDLSNN 380
            |||..|.|  :...|||..:.|:.||..||..|..|.|:.|.|..||..:|.|...|..::||||
Mouse    32 SCPMKCLCHPSSNSVDCSGQGLSKVPRDLPPWTVTLLLQDNRIHWLPALAFQSVSLLSTLNLSNN 96

  Fly   381 NISRIAHDALSGLKQLTTLVLYGNKIKDLPSGVFKGLGSLQLLLLNANEISCIRKDAFRDLHSLS 445
            ::|.:|.:|..||..|..|.:..|.:..:.|.....|..|:.|.|::|.:..:.....:...:|:
Mouse    97 SLSNLAAEAFYGLPHLRVLNVTQNSLLSIESSFAHALPGLRELDLSSNSLRILPTSLGKPWENLT 161

  Fly   446 LLSLYDNNIQSLANGTFDAMKSIKTVHLAKNPFICDCNL----RWLADYLHKNPIETSGARCESP 506
            :.::..|::..|.....:||..::.|.|..||:||||:|    .||..:..:.. ||.||.|..|
Mouse   162 VFAVQQNHLLHLDRELLEAMPKVRLVLLKDNPWICDCHLLGLKLWLERFTFQGG-ETDGAICRLP 225

  Fly   507 KRMHRRRIESLREEKFK-CS 525
            :....:.:.|:..|.:: ||
Mouse   226 EPWQGKALLSIPHELYQPCS 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sli	NP_001261017.1	LRRNT	73..103	CDD:214470
		leucine-rich repeat	83..104	CDD:275380
		LRR_8	102..160	CDD:290566
		leucine-rich repeat	105..125	CDD:275380
		LRR_RI	<119..259	CDD:238064
		leucine-rich repeat	126..149	CDD:275380
		LRR_8	149..208	CDD:290566
		leucine-rich repeat	150..173	CDD:275380
		leucine-rich repeat	174..197	CDD:275380
		LRR_8	197..256	CDD:290566
		leucine-rich repeat	198..221	CDD:275380
		leucine-rich repeat	222..245	CDD:275380
		leucine-rich repeat	246..371	CDD:275380	22/54 (41%)
		LRRCT	254..303	CDD:214507
		LRRNT	319..350	CDD:214470	13/32 (41%)
		LRR_8	349..406	CDD:290566	21/56 (38%)
		LRR_4	371..411	CDD:289563	13/39 (33%)
		leucine-rich repeat	372..395	CDD:275380	10/22 (45%)
		leucine-rich repeat	396..415	CDD:275380	4/18 (22%)
		leucine-rich repeat	420..443	CDD:275380	4/22 (18%)
		leucine-rich repeat	444..465	CDD:275380	3/20 (15%)
		leucine-rich repeat	468..480	CDD:275378	4/11 (36%)
		LRRCT	476..525	CDD:214507	17/53 (32%)
		leucine-rich repeat	484..545	CDD:275380	13/47 (28%)
		LRRNT	542..574	CDD:214470
		leucine-rich repeat	552..570	CDD:275380
		leucine-rich repeat	572..596	CDD:275380
		LRR_RI	<574..>678	CDD:238064
		LRR_8	595..655	CDD:290566
		leucine-rich repeat	597..620	CDD:275380
		leucine-rich repeat	621..644	CDD:275380
		leucine-rich repeat	645..668	CDD:275380
		leucine-rich repeat	669..756	CDD:275380
		LRRCT	677..726	CDD:214507
		LRRNT	739..770	CDD:214470
		leucine-rich repeat	757..791	CDD:275380
		LRR_4	770..807	CDD:289563
		LRR_8	790..850	CDD:290566
		LRR_4	791..830	CDD:289563
		leucine-rich repeat	792..815	CDD:275380
		LRR_4	814..863	CDD:289563
		leucine-rich repeat	816..839	CDD:275380
		leucine-rich repeat	840..861	CDD:275380
		LRRCT	872..920	CDD:214507
		EGF	935..966	CDD:278437
		EGF_CA	971..1007	CDD:238011
		EGF_CA	1009..1045	CDD:238011
		EGF_CA	1055..1086	CDD:238011
		EGF_CA	1088..1124	CDD:238011
		Laminin_G_1	1204..1335	CDD:278483
		CT	1435..1504	CDD:214482
Lrtm1	NP_795894.1	LRRNT	33..62	CDD:214470	11/28 (39%)
		leucine-rich repeat	45..63	CDD:275380	8/17 (47%)
		LRR 1	63..84		8/20 (40%)
		leucine-rich repeat	64..111	CDD:275378	19/46 (41%)
		LRR 2	87..108		8/20 (40%)
		LRR_8	110..170	CDD:290566	11/59 (19%)
		LRR_4	110..151	CDD:289563	9/40 (23%)
		LRR 3	111..132		4/20 (20%)
		leucine-rich repeat	112..135	CDD:275378	5/22 (23%)
		LRR 4	135..156		4/20 (20%)
		leucine-rich repeat	136..159	CDD:275378	4/22 (18%)
		LRR 5	159..180		3/20 (15%)
		leucine-rich repeat	160..183	CDD:275378	5/22 (23%)
		leucine-rich repeat	184..196	CDD:275378	4/11 (36%)
		TPKR_C2	192..239	CDD:301599	16/47 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	255..288
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45836
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010