DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sli and Adgra3

DIOPT Version :9

Sequence 1:	NP_001261017.1	Gene:	sli / 36746	FlyBaseID:	FBgn0264089	Length:	2157	Species:	Drosophila melanogaster
Sequence 2:	XP_038948686.1	Gene:	Adgra3 / 305408	RGDID:	1304914	Length:	1307	Species:	Rattus norvegicus

Alignment Length:	795	Identity:	168/795 - (21%)
Similarity:	258/795 - (32%)	Gaps:	273/795 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   319 CPHPCRC--------ADGIVDCREKSLTSV--PVTLPDDTTELRLEQNFITELPPKSFSSFRRLR 373
            |.|..|.        |:|.|.|....|..|  |.|||:.|..|.|..|.|:||...|||....|.
  Rat    30 CKHDGRARGTGRAAGAEGKVVCSSLELAQVLPPDTLPNRTVTLILSNNKISELKNGSFSGLSLLE 94

  Fly   374 RIDLSNNNISRIAHDALSGLKQLTTLVLYGNKIKDLPSGVFKGLGSLQLLLLNANEISCIRKDAF 438
            |:||.||.|||||                        .|.|.||.||:.|.|..|.|.|:..|.|
  Rat    95 RLDLRNNLISRIA------------------------PGAFWGLSSLKRLDLTNNRIGCLNADVF 135

  Fly   439 RDLHSLSLLSLYDNNIQSLANGTFDAMKSIKTVHLAKNPFICDCNLRWLADYLHKNPIETSGARC 503
            |.|.:|..|:|..|...||:.||||.:.|::::.......:||||:.|:..::.:..|.....||
  Rat   136 RGLTNLVRLNLSGNLFTSLSQGTFDYLGSLRSLEFQTEYLLCDCNILWMHRWVKERNITVRDTRC 200

  Fly   504 ESPKRMHRRRIESLREEKFKCSWDELRMKLSGECRMDSDCPAMCHCEGTTVDCTGRGLKEIPR-- 566
            ..||.:..:.:..:::|...|.                  |.:                |:|.
  Rat   201 VYPKSLQAQPVTGVKQELLTCG------------------PPL----------------ELPSFY 231

  Fly   567 DIPLHTTELLLNDNELGRISSDGLFGRLPHLVKLELKRNQLTGIEPNAFEGASHI-QELQL---G 627
            ..|.|...:...|:             ||....                  ||:| |::|:   .
  Rat   232 MTPSHRQVVFEGDS-------------LPFQCM------------------ASYIDQDMQVLWYQ 265

  Fly   628 ENKIKEI--SNKMFLGLHQLKTLNLYDNQISCVMPGSFEHLNSLTSLNL-ASNPFNCNCHLAWFA 689
            :.:|.|.  |..:|:....:...:|.              .::||..|: |.:..|..||:.
  Rat   266 DGRIVETDESQGIFVEKSMIHNCSLI--------------ASALTISNIQAGSTGNWGCHIQ--- 313

  Fly   690 EWLRKKSLNGGAARCGAPSKVRDVQIKDLPHSEFKCSSENSEGCLGDGYCPPSCTCTGTVVRCSR 754
               .|:..|           .|.|.|..|..|...|..|......||...|.:.......::|:|
  Rat   314 ---TKRGNN-----------TRTVDIVVLESSAQYCPPERVVNNKGDFRWPRTLAGITAYLQCTR 364

  Fly   755 NQLKEIPRGIPAETSELYLESNEIEQ--------------IHYERIRHLRSLTRLDLSNNQITIL 805
            |          :.:|.:|..:.:.|:              ..|.|.::...:||:....||:.:
  Rat   365 N----------SHSSGVYPGNTQDERKAWRRCDRGGFWADDDYSRCQYANDVTRVLYMFNQMPL- 418

  Fly   806 SNYTFANLTKLSTLIISYNKLQCLQRHALSGLNNLRVLSLHGNRISMLPEGSFEDLKSLTHIALG 870
             |.|  |....:..:::|.                            :...:|.|...:..:|
  Rat   419 -NLT--NAVATARQLLAYT----------------------------VEAANFSDKMDVIFVA-- 450

  Fly   871 SNPLYCDCGLKWFSDWIKLDYVEPGIARCAEPEQMKD--KLILSTPSSSFVCRGRVRNDILAKCN 933
                               :.:|. ..|..:.|:.|:  .:::...|:..:...||......:..
  Rat   451 -------------------EMIEK-FGRFTKEEKSKELGDVMVDVASNIMLADERVLWLAQREAK 495

  Fly   934 ACFEQPCQNQAQCVALPQREYQCLCQPGYH----GKHCEFMIDACYGNPCRNNA-TCTVLEEGRF 993
            ||               .|..|||.:...|    |.|       .|.....|.| ...|::
  Rat   496 AC---------------SRIVQCLQRIATHRLASGAH-------VYSTYSPNIALEAYVIK---- 534

  Fly   994 SCQCAPGYTGARC----------ETNIDDCLGEIKCQNNATCIDGVESYKCECQPGFS-----GE 1043
                |.|:||..|          .|.:.| .|......|   :|...|:||.....||     ..
  Rat   535 ----AAGFTGMTCSVFQKVAASDRTGLSD-YGRRDPDGN---LDKQLSFKCNVSSTFSSLALKNT 591

  Fly  1044 FCDTKIQFCSPEFNP 1058
            ..:..||..|..|:|
  Rat   592 IMEASIQLPSSLFSP 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sli	NP_001261017.1	LRRNT	73..103	CDD:214470
		leucine-rich repeat	83..104	CDD:275380
		LRR_8	102..160	CDD:290566
		leucine-rich repeat	105..125	CDD:275380
		LRR_RI	<119..259	CDD:238064
		leucine-rich repeat	126..149	CDD:275380
		LRR_8	149..208	CDD:290566
		leucine-rich repeat	150..173	CDD:275380
		leucine-rich repeat	174..197	CDD:275380
		LRR_8	197..256	CDD:290566
		leucine-rich repeat	198..221	CDD:275380
		leucine-rich repeat	222..245	CDD:275380
		leucine-rich repeat	246..371	CDD:275380	23/61 (38%)
		LRRCT	254..303	CDD:214507
		LRRNT	319..350	CDD:214470	14/40 (35%)
		LRR_8	349..406	CDD:290566	20/56 (36%)
		LRR_4	371..411	CDD:289563	11/39 (28%)
		leucine-rich repeat	372..395	CDD:275380	11/22 (50%)
		leucine-rich repeat	396..415	CDD:275380	1/18 (6%)
		leucine-rich repeat	420..443	CDD:275380	10/22 (45%)
		leucine-rich repeat	444..465	CDD:275380	10/20 (50%)
		leucine-rich repeat	468..480	CDD:275378	0/11 (0%)
		LRRCT	476..525	CDD:214507	11/48 (23%)
		leucine-rich repeat	484..545	CDD:275380	8/60 (13%)
		LRRNT	542..574	CDD:214470	5/33 (15%)
		leucine-rich repeat	552..570	CDD:275380	2/19 (11%)
		leucine-rich repeat	572..596	CDD:275380	2/23 (9%)
		LRR_RI	<574..>678	CDD:238064	17/110 (15%)
		LRR_8	595..655	CDD:290566	11/65 (17%)
		leucine-rich repeat	597..620	CDD:275380	1/22 (5%)
		leucine-rich repeat	621..644	CDD:275380	7/28 (25%)
		leucine-rich repeat	645..668	CDD:275380	1/22 (5%)
		leucine-rich repeat	669..756	CDD:275380	21/87 (24%)
		LRRCT	677..726	CDD:214507	10/48 (21%)
		LRRNT	739..770	CDD:214470	4/30 (13%)
		leucine-rich repeat	757..791	CDD:275380	5/47 (11%)
		LRR_4	770..807	CDD:289563	8/50 (16%)
		LRR_8	790..850	CDD:290566	8/59 (14%)
		LRR_4	791..830	CDD:289563	8/38 (21%)
		leucine-rich repeat	792..815	CDD:275380	7/22 (32%)
		LRR_4	814..863	CDD:289563	3/48 (6%)
		leucine-rich repeat	816..839	CDD:275380	1/22 (5%)
		leucine-rich repeat	840..861	CDD:275380	1/20 (5%)
		LRRCT	872..920	CDD:214507	5/49 (10%)
		EGF	935..966	CDD:278437	7/34 (21%)
		EGF_CA	971..1007	CDD:238011	9/46 (20%)
		EGF_CA	1009..1045	CDD:238011	9/40 (23%)
		EGF_CA	1055..1086	CDD:238011	2/4 (50%)
		EGF_CA	1088..1124	CDD:238011
		Laminin_G_1	1204..1335	CDD:278483
		CT	1435..1504	CDD:214482
Adgra3	XP_038948686.1	leucine-rich repeat	69..92	CDD:275378	10/22 (45%)
		LRR_8	71..127	CDD:404697	29/79 (37%)
		leucine-rich repeat	93..116	CDD:275378	15/46 (33%)
		LRR_8	115..168	CDD:404697	22/52 (42%)
		leucine-rich repeat	117..140	CDD:275378	10/22 (45%)
		PCC	121..>226	CDD:188093	32/138 (23%)
		leucine-rich repeat	141..164	CDD:275378	10/22 (45%)
		Ig_3	228..310	CDD:404760	21/126 (17%)
		HRM	<349..402	CDD:397086	9/62 (15%)
		GPS	685..729	CDD:396408
		7tmB2_GPR125	742..1049	CDD:320665
		TM helix 1	745..769	CDD:320665
		TM helix 2	781..802	CDD:320665
		TM helix 3	812..834	CDD:320665
		TM helix 4	862..878	CDD:320665
		TM helix 5	899..922	CDD:320665
		TM helix 6	982..1004	CDD:320665
		TM helix 7	1011..1036	CDD:320665
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910