DRSC/TRiP Functional Genomics Resources

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Protein Alignment sli and Rtn4rl1

DIOPT Version :9

Sequence 1:NP_001261017.1 Gene:sli / 36746 FlyBaseID:FBgn0264089 Length:2157 Species:Drosophila melanogaster
Sequence 2:NP_852042.1 Gene:Rtn4rl1 / 303311 RGDID:727812 Length:445 Species:Rattus norvegicus


Alignment Length:551 Identity:116/551 - (21%)
Similarity:173/551 - (31%) Gaps:247/551 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 ILLLLRHDAVHAEPYSGGFGSSAVSSGGLGSVGIHIPGGGVGVITEARCPRVCSC--TGLNVDCS 87
            :||||..:.    |.|||                              |||.|.|  :.:.|.|.
  Rat    11 LLLLLAGEL----PLSGG------------------------------CPRDCVCYPSPMTVSCQ 41

  Fly    88 HRGLTSVPRKISADVERLELQGNNLTVIYETDFQRLTKLRMLQLTDNQIHTIERNSFQDLVSLER 152
            .....::|..|..|.||:.||.|::|.:.:..|                                
  Rat    42 AHNFAAIPEGIPEDSERIFLQNNHITFLQQGHF-------------------------------- 74

  Fly   153 LRLNNNRLKAIPENFVTSSASLLRLDISNNVITTVGRRVFKGAQSLRSLQL-DNNQITCLDEHAF 216
                              |.:::.|.|.:|.||.:....|:|...|..|.| ||.|:..|....|
  Rat    75 ------------------SPAMVTLWIYSNNITFIAPNTFEGFVHLEELDLGDNRQLRTLAPETF 121

  Fly   217 KGLVELEILTLNNNNLTSLPHNIFGGLGRLRALRLSDNPFACDCHLSWLSRFLRSATRLAPYTRC 281
            :|||:|..|.|....|:|||..|||||..|:.|.|.||      |:.:|.               
  Rat   122 QGLVKLHALYLYKCGLSSLPAGIFGGLHSLQYLYLQDN------HIEYLQ--------------- 165

  Fly   282 QSPSQLKGQNVADLHDQEFKCSGLTEHAPMECGAENSCPHPCRCADGIVDCREKSLTSVPVTLPD 346
                                                                            |
  Rat   166 ----------------------------------------------------------------D 166

  Fly   347 DTTELRLEQNFITELPPKSFSSFRRLRRIDLSNNNISRIAHDALSGLKQLTTLVLYGNKIKDLPS 411
            |..                         :||.|                |:.|.|:|||:..|..
  Rat   167 DIF-------------------------VDLVN----------------LSHLFLHGNKLWSLGQ 190

  Fly   412 GVFKGLGSLQLLLLNANEISCIRKDAFRDLHSLSLLSLYDNNIQSLANGTFDAMKSIKTVHLAKN 476
            |:|:||.:|..|||:.|::..:...||.|||.|:.|.|::|::..|.......:.:::.:.|..|
  Rat   191 GIFRGLVNLDRLLLHENQLQWVHHKAFHDLHRLTTLFLFNNSLTELQGDCLAPLVALEFLRLNGN 255

  Fly   477 PFICDCNLRWLADYLHKNPIETSGARCESPKRMHRRRIESLREEKFKCSWDELRMKLSGECRMDS 541
            .:.|.|..|.|.::|.:....:|...|.:|:....:.::|||.|.|:                  
  Rat   256 AWDCGCRARSLWEWLRRFRGSSSVVPCATPELRQGQDLKSLRVEDFR------------------ 302

  Fly   542 DCPAMCHCEGTTVDCTGRGLKEIPRDIPLHT 572
                         :|||   ...|..|..||
  Rat   303 -------------NCTG---PASPHQIKSHT 317

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sliNP_001261017.1 LRRNT 73..103 CDD:214470 10/31 (32%)
leucine-rich repeat 83..104 CDD:275380 5/20 (25%)
LRR_8 102..160 CDD:290566 7/57 (12%)
leucine-rich repeat 105..125 CDD:275380 5/19 (26%)
LRR_RI <119..259 CDD:238064 37/140 (26%)
leucine-rich repeat 126..149 CDD:275380 0/22 (0%)
LRR_8 149..208 CDD:290566 13/59 (22%)
leucine-rich repeat 150..173 CDD:275380 1/22 (5%)
leucine-rich repeat 174..197 CDD:275380 7/22 (32%)
LRR_8 197..256 CDD:290566 28/59 (47%)
leucine-rich repeat 198..221 CDD:275380 10/23 (43%)
leucine-rich repeat 222..245 CDD:275380 12/22 (55%)
leucine-rich repeat 246..371 CDD:275380 9/124 (7%)
LRRCT 254..303 CDD:214507 3/48 (6%)
LRRNT 319..350 CDD:214470 2/30 (7%)
LRR_8 349..406 CDD:290566 8/56 (14%)
LRR_4 371..411 CDD:289563 10/39 (26%)
leucine-rich repeat 372..395 CDD:275380 3/22 (14%)
leucine-rich repeat 396..415 CDD:275380 8/18 (44%)
leucine-rich repeat 420..443 CDD:275380 9/22 (41%)
leucine-rich repeat 444..465 CDD:275380 5/20 (25%)
leucine-rich repeat 468..480 CDD:275378 2/11 (18%)
LRRCT 476..525 CDD:214507 14/48 (29%)
leucine-rich repeat 484..545 CDD:275380 11/60 (18%)
LRRNT 542..574 CDD:214470 7/31 (23%)
leucine-rich repeat 552..570 CDD:275380 5/17 (29%)
leucine-rich repeat 572..596 CDD:275380 1/1 (100%)
LRR_RI <574..>678 CDD:238064
LRR_8 595..655 CDD:290566
leucine-rich repeat 597..620 CDD:275380
leucine-rich repeat 621..644 CDD:275380
leucine-rich repeat 645..668 CDD:275380
leucine-rich repeat 669..756 CDD:275380
LRRCT 677..726 CDD:214507
LRRNT 739..770 CDD:214470
leucine-rich repeat 757..791 CDD:275380
LRR_4 770..807 CDD:289563
LRR_8 790..850 CDD:290566
LRR_4 791..830 CDD:289563
leucine-rich repeat 792..815 CDD:275380
LRR_4 814..863 CDD:289563
leucine-rich repeat 816..839 CDD:275380
leucine-rich repeat 840..861 CDD:275380
LRRCT 872..920 CDD:214507
EGF 935..966 CDD:278437
EGF_CA 971..1007 CDD:238011
EGF_CA 1009..1045 CDD:238011
EGF_CA 1055..1086 CDD:238011
EGF_CA 1088..1124 CDD:238011
Laminin_G_1 1204..1335 CDD:278483
CT 1435..1504 CDD:214482
Rtn4rl1NP_852042.1 leucine-rich repeat 37..58 CDD:275380 5/20 (25%)
LRR 1 55..76 8/70 (11%)
LRR 2 77..98 6/20 (30%)
leucine-rich repeat 78..101 CDD:275380 7/22 (32%)
LRR_8 85..132 CDD:404697 18/46 (39%)
LRR 3 101..123 8/21 (38%)
leucine-rich repeat 102..126 CDD:275380 10/23 (43%)
PPP1R42 126..>255 CDD:411060 51/254 (20%)
LRR 4 126..147 9/20 (45%)
leucine-rich repeat 127..150 CDD:275380 12/22 (55%)
LRR 5 150..171 9/130 (7%)
leucine-rich repeat 151..174 CDD:275380 11/132 (8%)
LRR_8 174..233 CDD:404697 26/74 (35%)
LRR 6 174..195 10/36 (28%)
leucine-rich repeat 175..198 CDD:275380 11/22 (50%)
LRR 7 198..219 7/20 (35%)
leucine-rich repeat 199..222 CDD:275380 9/22 (41%)
LRR 8 222..243 5/20 (25%)
leucine-rich repeat 223..246 CDD:275380 5/22 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 304..380 7/17 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 401..421
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45836
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
33.010

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