DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sli and Nyx

DIOPT Version :9

Sequence 1:	NP_001261017.1	Gene:	sli / 36746	FlyBaseID:	FBgn0264089	Length:	2157	Species:	Drosophila melanogaster
Sequence 2:	NP_001094437.1	Gene:	Nyx / 302516	RGDID:	1561300	Length:	476	Species:	Rattus norvegicus

Alignment Length:	450	Identity:	109/450 - (24%)
Similarity:	164/450 - (36%)	Gaps:	120/450 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 TEA---RCPRVCSCT----GLNVDCSHRGLTSVPRKISADVERLELQGNNLTVIYETDFQRLTKL 126
            |||   .||..|:|:    |.:|.|...||..||.:...:...::|..|.|.::.|..|..|..|
  Rat    19 TEACLRACPAACTCSNVERGCSVRCDRAGLQRVPTEFPCEAASIDLDRNGLRILGERAFGTLPSL 83

  Fly   127 RMLQLTDNQIHTIERNSFQDLVSLERLRL-NNNRLKAIPENFVTSSASLLRLDISNNVITTVGRR 190
            |.|.|..|.:..|...:|:.|..|..||| :|..|:.:......:...|.|||::...:.:|..|
  Rat    84 RCLSLRHNNLSFITPGAFKGLPRLAELRLAHNGELRYLHVRTFAALGRLRRLDLAACRLFSVPER 148

  Fly   191 VFKGAQSLRSLQLDNNQITCLDEHAFKGLVELEILTLNNNNLTSLPHNIFGGLGRLRALRLSDNP 255
            :.....:||.|...:|....: ..|.:||..|.......:.:.::..:...|:.|||:|.|..|
  Rat   149 LLAELPALRELTAFDNLFRRV-PGALRGLANLTHAHFERSRIEAVASSSLLGMRRLRSLSLQAN- 211

  Fly   256 FACDCHLSWLSRFLRSATRLAPYTRCQSPSQLKGQNVADLHDQEFKCSGLTEHAPMECGAENSCP 320
                                               .|..:|                .||...|
  Rat   212 -----------------------------------RVRAVH----------------AGAFGDC- 224

  Fly   321 HPCRCADGIVDCREKSLTSVPVTLPDDTTELRLEQNFITELPPKSFSSFRRLRRIDLSNNNISRI 385
                                 |.|    ..|.|..|.:..||..:|...||||.::|..|.:..:
  Rat   225 ---------------------VAL----EHLLLNDNLLASLPAAAFRGLRRLRTLNLGGNALGSV 264

  Fly   386 AHDALSGLKQLTTLVLYGNKIKDLPSGVFKGLGSLQLLLLNANEISCIRKDAFRDLHSLSLLSLY 450
            |.                        |.|..|..|:||.|:.|.|:.:.:.||::|..|..|.|.
  Rat   265 AR------------------------GWFSDLAELELLYLDRNSITFVEEGAFQNLSGLLALHLN 305

  Fly   451 DNNIQSLANGTFDAMKSIKTVHLAKNPFICDCNLRWLADYLHKNPIETSG----ARCESP 506
            .|.:..|:...|.....:..:.|.:||:.|||:|.||.|::     |.||    ..|.||
  Rat   306 GNRLTVLSWAAFQPGFFLGRLFLFRNPWRCDCHLEWLRDWM-----EGSGRVADVACASP 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sli	NP_001261017.1	LRRNT	73..103	CDD:214470	11/33 (33%)
		leucine-rich repeat	83..104	CDD:275380	6/20 (30%)
		LRR_8	102..160	CDD:290566	19/58 (33%)
		leucine-rich repeat	105..125	CDD:275380	6/19 (32%)
		LRR_RI	<119..259	CDD:238064	37/140 (26%)
		leucine-rich repeat	126..149	CDD:275380	8/22 (36%)
		LRR_8	149..208	CDD:290566	16/59 (27%)
		leucine-rich repeat	150..173	CDD:275380	6/23 (26%)
		leucine-rich repeat	174..197	CDD:275380	6/22 (27%)
		LRR_8	197..256	CDD:290566	15/58 (26%)
		leucine-rich repeat	198..221	CDD:275380	7/22 (32%)
		leucine-rich repeat	222..245	CDD:275380	2/22 (9%)
		leucine-rich repeat	246..371	CDD:275380	18/124 (15%)
		LRRCT	254..303	CDD:214507	3/48 (6%)
		LRRNT	319..350	CDD:214470	3/30 (10%)
		LRR_8	349..406	CDD:290566	13/56 (23%)
		LRR_4	371..411	CDD:289563	6/39 (15%)
		leucine-rich repeat	372..395	CDD:275380	5/22 (23%)
		leucine-rich repeat	396..415	CDD:275380	1/18 (6%)
		leucine-rich repeat	420..443	CDD:275380	9/22 (41%)
		leucine-rich repeat	444..465	CDD:275380	6/20 (30%)
		leucine-rich repeat	468..480	CDD:275378	3/11 (27%)
		LRRCT	476..525	CDD:214507	14/34 (41%)
		leucine-rich repeat	484..545	CDD:275380	9/26 (35%)
		LRRNT	542..574	CDD:214470
		leucine-rich repeat	552..570	CDD:275380
		leucine-rich repeat	572..596	CDD:275380
		LRR_RI	<574..>678	CDD:238064
		LRR_8	595..655	CDD:290566
		leucine-rich repeat	597..620	CDD:275380
		leucine-rich repeat	621..644	CDD:275380
		leucine-rich repeat	645..668	CDD:275380
		leucine-rich repeat	669..756	CDD:275380
		LRRCT	677..726	CDD:214507
		LRRNT	739..770	CDD:214470
		leucine-rich repeat	757..791	CDD:275380
		LRR_4	770..807	CDD:289563
		LRR_8	790..850	CDD:290566
		LRR_4	791..830	CDD:289563
		leucine-rich repeat	792..815	CDD:275380
		LRR_4	814..863	CDD:289563
		leucine-rich repeat	816..839	CDD:275380
		leucine-rich repeat	840..861	CDD:275380
		LRRCT	872..920	CDD:214507
		EGF	935..966	CDD:278437
		EGF_CA	971..1007	CDD:238011
		EGF_CA	1009..1045	CDD:238011
		EGF_CA	1055..1086	CDD:238011
		EGF_CA	1088..1124	CDD:238011
		Laminin_G_1	1204..1335	CDD:278483
		CT	1435..1504	CDD:214482
Nyx	NP_001094437.1	LRRNT	25..56	CDD:214470	11/30 (37%)
		leucine-rich repeat	63..82	CDD:275380	6/18 (33%)
		LRR_RI	<68..312	CDD:238064	75/346 (22%)
		LRR_8	81..142	CDD:290566	18/60 (30%)
		leucine-rich repeat	83..106	CDD:275380	8/22 (36%)
		leucine-rich repeat	107..131	CDD:275380	6/23 (26%)
		leucine-rich repeat	132..155	CDD:275380	6/22 (27%)
		leucine-rich repeat	156..178	CDD:275380	7/22 (32%)
		leucine-rich repeat	179..202	CDD:275380	2/22 (9%)
		LRR_8	201..261	CDD:290566	25/137 (18%)
		leucine-rich repeat	203..226	CDD:275380	10/96 (10%)
		leucine-rich repeat	227..250	CDD:275380	7/26 (27%)
		LRR_8	249..309	CDD:290566	23/83 (28%)
		leucine-rich repeat	251..274	CDD:275380	8/46 (17%)
		leucine-rich repeat	275..296	CDD:275380	8/20 (40%)
		leucine-rich repeat	299..318	CDD:275380	5/18 (28%)
		LRRCT	331..>366	CDD:214507	14/34 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4237
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810