DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sli and Vasn

DIOPT Version :9

Sequence 1:	NP_001261017.1	Gene:	sli / 36746	FlyBaseID:	FBgn0264089	Length:	2157	Species:	Drosophila melanogaster
Sequence 2:	NP_647468.2	Gene:	Vasn / 246154	MGIID:	2177651	Length:	673	Species:	Mus musculus

Alignment Length:	494	Identity:	124/494 - (25%)
Similarity:	192/494 - (38%)	Gaps:	96/494 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   543 CPAMCHC-EGTTVDCTGRGLKEIPRDIPLHTTELLLNDNELGRISSDGLFGRLPHLVKLELKRNQ 606
            ||:.|.| :..||.||.|....:|||:|..|..|.:.:|.:..:.. |.|..||.|..|:|.:||
Mouse    25 CPSGCQCNQPQTVFCTARQGTTVPRDVPPDTVGLYIFENGITTLDV-GCFAGLPGLQLLDLSQNQ 88

  Fly   607 LTGIEPNAFEGASHIQELQLGENKIKEISNKMFLGLHQLKTLNLYDNQISCVMPGSFEHLNSLTS 671
            :|.:....|:...::..|.|..||:.||||:.|.||.:|:.|.|..|:|..:.||:|:.|:.|..
Mouse    89 ITSLPGGIFQPLVNLSNLDLTANKLHEISNETFRGLRRLERLYLGKNRIRHIQPGAFDALDRLLE 153

  Fly   672 LNLASNPFNCNCHLAWFAEWLRKKSLNGGAARCGAPSKVRDVQIKDLPHSEFKCSSENSEGCLGD 736
            |.|..|..                       |...|..:..:.:.||.|        ||...|..
Mouse   154 LKLPDNEL-----------------------RVLPPLHLPRLLLLDLSH--------NSIPALEA 187

  Fly   737 GYCPPSCTCTGTVVRCSRNQLKEIPRGIPAETSELY---LESNEIEQIHYERIRHLRSLTRLDLS 798
            |...   |.....:|.:...|:::..|:......|:   :..|::|.:. ..|:.||.||||.|:
Mouse   188 GILD---TANVEALRLAGLGLRQLDEGLFGRLLNLHDLDVSDNQLEHMP-SVIQGLRGLTRLRLA 248

  Fly   799 -NNQITILSNYTFANLTKLSTLIISYNKLQCLQRHALSGLNNLRVLSLHGNRISMLPEGSFEDLK 862
             |.:|..:.....|.||.|..|.:|...||.|.....|....||:|
Mouse   249 GNTRIAQIRPEDLAGLTALQELDVSNLSLQALPSDLSSLFPRLRLL------------------- 294

  Fly   863 SLTHIALGSNPLYCDCGLKWFSDWIKLDYV---EPGIARCAEPEQMKDKLILSTPSSSFVC---- 920
                 |...||..|.|.|.||..|::.::|   .|...||..|.:...:|:|....:.|.|
Mouse   295 -----AAARNPFNCLCPLSWFGPWVRENHVVLASPEETRCHFPPKNAGRLLLDLDYADFGCPVTT 354

  Fly   921 --------RGRVRNDILAKCNAC-----FEQPCQNQAQCVALPQREYQCLCQPGYHGKHCEFMID 972
                    |..:|...|:..:..     ..:|....:..::......:...||           .
Mouse   355 TTATVPTIRSTIREPTLSTSSQAPTWPSLTEPTTQASTVLSTAPPTMRPAPQP-----------Q 408

  Fly   973 ACYGNPCRNNATCTVLEEGRFSCQCAPGYTGARCETNID 1011
            .|..:.|.|..:|.:.....:.|.|..|:.|..||:.::
Mouse   409 DCPASICLNGGSCRLGARHHWECLCPEGFIGLYCESPVE 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sli	NP_001261017.1	LRRNT	73..103	CDD:214470
		leucine-rich repeat	83..104	CDD:275380
		LRR_8	102..160	CDD:290566
		leucine-rich repeat	105..125	CDD:275380
		LRR_RI	<119..259	CDD:238064
		leucine-rich repeat	126..149	CDD:275380
		LRR_8	149..208	CDD:290566
		leucine-rich repeat	150..173	CDD:275380
		leucine-rich repeat	174..197	CDD:275380
		LRR_8	197..256	CDD:290566
		leucine-rich repeat	198..221	CDD:275380
		leucine-rich repeat	222..245	CDD:275380
		leucine-rich repeat	246..371	CDD:275380
		LRRCT	254..303	CDD:214507
		LRRNT	319..350	CDD:214470
		LRR_8	349..406	CDD:290566
		LRR_4	371..411	CDD:289563
		leucine-rich repeat	372..395	CDD:275380
		leucine-rich repeat	396..415	CDD:275380
		leucine-rich repeat	420..443	CDD:275380
		leucine-rich repeat	444..465	CDD:275380
		leucine-rich repeat	468..480	CDD:275378
		LRRCT	476..525	CDD:214507
		leucine-rich repeat	484..545	CDD:275380	1/1 (100%)
		LRRNT	542..574	CDD:214470	14/31 (45%)
		leucine-rich repeat	552..570	CDD:275380	8/17 (47%)
		leucine-rich repeat	572..596	CDD:275380	6/23 (26%)
		LRR_RI	<574..>678	CDD:238064	36/103 (35%)
		LRR_8	595..655	CDD:290566	23/59 (39%)
		leucine-rich repeat	597..620	CDD:275380	7/22 (32%)
		leucine-rich repeat	621..644	CDD:275380	11/22 (50%)
		leucine-rich repeat	645..668	CDD:275380	9/22 (41%)
		leucine-rich repeat	669..756	CDD:275380	15/86 (17%)
		LRRCT	677..726	CDD:214507	6/48 (13%)
		LRRNT	739..770	CDD:214470	4/30 (13%)
		leucine-rich repeat	757..791	CDD:275380	7/36 (19%)
		LRR_4	770..807	CDD:289563	13/40 (33%)
		LRR_8	790..850	CDD:290566	21/60 (35%)
		LRR_4	791..830	CDD:289563	15/39 (38%)
		leucine-rich repeat	792..815	CDD:275380	9/23 (39%)
		LRR_4	814..863	CDD:289563	11/48 (23%)
		leucine-rich repeat	816..839	CDD:275380	7/22 (32%)
		leucine-rich repeat	840..861	CDD:275380	3/20 (15%)
		LRRCT	872..920	CDD:214507	16/50 (32%)
		EGF	935..966	CDD:278437	3/35 (9%)
		EGF_CA	971..1007	CDD:238011	8/35 (23%)
		EGF_CA	1009..1045	CDD:238011	0/3 (0%)
		EGF_CA	1055..1086	CDD:238011
		EGF_CA	1088..1124	CDD:238011
		Laminin_G_1	1204..1335	CDD:278483
		CT	1435..1504	CDD:214482
Vasn	NP_647468.2	LRRNT	24..55	CDD:214470	13/29 (45%)
		leucine-rich repeat	35..57	CDD:275380	10/21 (48%)
		LRR 1	54..75		5/21 (24%)
		LRR_8	58..113	CDD:290566	16/55 (29%)
		leucine-rich repeat	58..78	CDD:275380	5/20 (25%)
		LRR_RI	<76..273	CDD:238064	64/231 (28%)
		LRR_4	77..118	CDD:289563	14/40 (35%)
		LRR 2	78..99		7/20 (35%)
		leucine-rich repeat	79..102	CDD:275380	7/22 (32%)
		LRR_8	102..161	CDD:290566	24/58 (41%)
		LRR 3	102..123		9/20 (45%)
		leucine-rich repeat	103..126	CDD:275380	11/22 (50%)
		LRR 4	126..147		8/20 (40%)
		leucine-rich repeat	127..150	CDD:275380	9/22 (41%)
		LRR 5	150..170		6/42 (14%)
		leucine-rich repeat	151..194	CDD:275380	14/76 (18%)
		LRR 6	171..192		7/31 (23%)
		LRR_8	194..250	CDD:290566	14/56 (25%)
		LRR 7	194..215		3/20 (15%)
		leucine-rich repeat	195..218	CDD:275380	3/22 (14%)
		LRR 8	218..239		4/21 (19%)
		leucine-rich repeat	219..241	CDD:275380	5/22 (23%)
		LRR_8	240..301	CDD:290566	23/84 (27%)
		LRR 9	241..265		8/23 (35%)
		leucine-rich repeat	242..266	CDD:275380	9/23 (39%)
		LRR 10	266..288		7/21 (33%)
		LRRCT	299..350	CDD:214507	16/50 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	369..389		2/19 (11%)
		EGF	410..441	CDD:278437	8/30 (27%)
		fn3	468..537	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	608..648
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910