DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sli and Lrrc3

DIOPT Version :9

Sequence 1:	NP_001261017.1	Gene:	sli / 36746	FlyBaseID:	FBgn0264089	Length:	2157	Species:	Drosophila melanogaster
Sequence 2:	NP_660134.1	Gene:	Lrrc3 / 237387	MGIID:	2447899	Length:	257	Species:	Mus musculus

Alignment Length:	217	Identity:	61/217 - (28%)
Similarity:	85/217 - (39%)	Gaps:	67/217 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   535 GEC-------RMDSDCPAMCHCE----GTTVDCTGRGLKEIPRDIPLHTTELLLNDNELGRISSD 588
            |.|       |:.:.||..|.|.    ...|.|:.|||:|||||||..|..|.|:.|.:.|: .:
Mouse    18 GSCFFILFCLRLGASCPQACQCPDHAGAVAVHCSSRGLQEIPRDIPADTVLLKLDANRISRV-PN 81

  Fly   589 GLFGRLPHLVKLELKRNQLTGIEPNAFEG-ASHIQELQLGENKIKEISNKMFLGLHQLKTLNLYD 652
            |.|..||.|.:|:|..|.:..|.|.||.| |..::.|.|..|:|:.|..
Mouse    82 GAFQHLPQLRELDLSHNAIEAIGPAAFSGLAGGLRLLDLSHNRIRRIPK---------------- 130

  Fly   653 NQISCVMPGSFEHLNSLTS-LNLASNPFNCNCHLAWFAEWLRK---------------------- 694
                       :.|..|:: :.|:.||.:|.|.|. .|.|..|
Mouse   131 -----------DALGKLSAKIRLSHNPLHCECALQ-EALWELKLDPDSVDEIACHTSAQEQFVGK 183

  Fly   695 ---KSLNGGAARCGAPSKVRDV 713
               :.|:.||:.|....|..||
Mouse   184 PLIQVLDSGASFCSTHRKTTDV 205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sli	NP_001261017.1	LRRNT	73..103	CDD:214470
		leucine-rich repeat	83..104	CDD:275380
		LRR_8	102..160	CDD:290566
		leucine-rich repeat	105..125	CDD:275380
		LRR_RI	<119..259	CDD:238064
		leucine-rich repeat	126..149	CDD:275380
		LRR_8	149..208	CDD:290566
		leucine-rich repeat	150..173	CDD:275380
		leucine-rich repeat	174..197	CDD:275380
		LRR_8	197..256	CDD:290566
		leucine-rich repeat	198..221	CDD:275380
		leucine-rich repeat	222..245	CDD:275380
		leucine-rich repeat	246..371	CDD:275380
		LRRCT	254..303	CDD:214507
		LRRNT	319..350	CDD:214470
		LRR_8	349..406	CDD:290566
		LRR_4	371..411	CDD:289563
		leucine-rich repeat	372..395	CDD:275380
		leucine-rich repeat	396..415	CDD:275380
		leucine-rich repeat	420..443	CDD:275380
		leucine-rich repeat	444..465	CDD:275380
		leucine-rich repeat	468..480	CDD:275378
		LRRCT	476..525	CDD:214507
		leucine-rich repeat	484..545	CDD:275380	4/16 (25%)
		LRRNT	542..574	CDD:214470	17/35 (49%)
		leucine-rich repeat	552..570	CDD:275380	11/17 (65%)
		leucine-rich repeat	572..596	CDD:275380	8/23 (35%)
		LRR_RI	<574..>678	CDD:238064	26/105 (25%)
		LRR_8	595..655	CDD:290566	16/60 (27%)
		leucine-rich repeat	597..620	CDD:275380	10/23 (43%)
		leucine-rich repeat	621..644	CDD:275380	5/22 (23%)
		leucine-rich repeat	645..668	CDD:275380	1/22 (5%)
		leucine-rich repeat	669..756	CDD:275380	17/71 (24%)
		LRRCT	677..726	CDD:214507	15/62 (24%)
		LRRNT	739..770	CDD:214470
		leucine-rich repeat	757..791	CDD:275380
		LRR_4	770..807	CDD:289563
		LRR_8	790..850	CDD:290566
		LRR_4	791..830	CDD:289563
		leucine-rich repeat	792..815	CDD:275380
		LRR_4	814..863	CDD:289563
		leucine-rich repeat	816..839	CDD:275380
		leucine-rich repeat	840..861	CDD:275380
		LRRCT	872..920	CDD:214507
		EGF	935..966	CDD:278437
		EGF_CA	971..1007	CDD:238011
		EGF_CA	1009..1045	CDD:238011
		EGF_CA	1055..1086	CDD:238011
		EGF_CA	1088..1124	CDD:238011
		Laminin_G_1	1204..1335	CDD:278483
		CT	1435..1504	CDD:214482
Lrrc3	NP_660134.1	LRRNT	33..68	CDD:214470	17/34 (50%)
		leucine-rich repeat	48..68	CDD:275378	13/19 (68%)
		LRR 1	65..86		7/21 (33%)
		LRR_8	69..125	CDD:290566	21/56 (38%)
		LRR_4	69..105	CDD:289563	13/36 (36%)
		leucine-rich repeat	69..89	CDD:275378	7/20 (35%)
		LRR_4	88..129	CDD:289563	15/40 (38%)
		LRR 2	89..110		8/20 (40%)
		leucine-rich repeat	90..114	CDD:275378	10/23 (43%)
		LRR 3	114..135		6/47 (13%)
		leucine-rich repeat	115..138	CDD:275378	7/49 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4237
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810