DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sli and LRRC55

DIOPT Version :9

Sequence 1:	NP_001261017.1	Gene:	sli / 36746	FlyBaseID:	FBgn0264089	Length:	2157	Species:	Drosophila melanogaster
Sequence 2:	NP_001005210.2	Gene:	LRRC55 / 219527	HGNCID:	32324	Length:	298	Species:	Homo sapiens

Alignment Length:	218	Identity:	64/218 - (29%)
Similarity:	102/218 - (46%)	Gaps:	5/218 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   311 MECGAENSCPHPCRCADGIVDCREKSLTSVPVTLPDDTTELRLEQNFITELPPKSFSSFRRLRRI 375
            |...|..|||..|.|.:.:|||..:.|.|||..||.||..|.|..|.||.:||...:.:..|:.:
Human    30 MHSDAGTSCPVLCTCRNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRITAVPPGYLTCYMELQVL 94

  Fly   376 DLSNNNISRIAHDALSGLKQLTTLVLYGNKIKDLPSGVFKGLGSLQLLLLNANE-ISCIRKDAFR 439
            ||.||::..:........|:|..|.|..|....:|:.:|:....|..:.|:.|. :..:...||:
Human    95 DLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRRVHPQAFQ 159

  Fly   440 DLHSLSLLSLYDNNIQSLANGTFDAMKSIKTVHLAKNPFICDCN----LRWLADYLHKNPIETSG 500
            .|..|..|.|....:..|:....:.:..:.|:.:..||::|.|.    |:||.:.:.:...::..
Human   160 GLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLRNRIQRCTADSQL 224

  Fly   501 ARCESPKRMHRRRIESLREEKFK 523
            |.|..|..:....:.||.||.||
Human   225 AECRGPPEVEGAPLFSLTEESFK 247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sli	NP_001261017.1	LRRNT	73..103	CDD:214470
		leucine-rich repeat	83..104	CDD:275380
		LRR_8	102..160	CDD:290566
		leucine-rich repeat	105..125	CDD:275380
		LRR_RI	<119..259	CDD:238064
		leucine-rich repeat	126..149	CDD:275380
		LRR_8	149..208	CDD:290566
		leucine-rich repeat	150..173	CDD:275380
		leucine-rich repeat	174..197	CDD:275380
		LRR_8	197..256	CDD:290566
		leucine-rich repeat	198..221	CDD:275380
		leucine-rich repeat	222..245	CDD:275380
		leucine-rich repeat	246..371	CDD:275380	25/59 (42%)
		LRRCT	254..303	CDD:214507
		LRRNT	319..350	CDD:214470	15/30 (50%)
		LRR_8	349..406	CDD:290566	17/56 (30%)
		LRR_4	371..411	CDD:289563	10/39 (26%)
		leucine-rich repeat	372..395	CDD:275380	5/22 (23%)
		leucine-rich repeat	396..415	CDD:275380	5/18 (28%)
		leucine-rich repeat	420..443	CDD:275380	6/23 (26%)
		leucine-rich repeat	444..465	CDD:275380	4/20 (20%)
		leucine-rich repeat	468..480	CDD:275378	3/11 (27%)
		LRRCT	476..525	CDD:214507	16/52 (31%)
		leucine-rich repeat	484..545	CDD:275380	12/40 (30%)
		LRRNT	542..574	CDD:214470
		leucine-rich repeat	552..570	CDD:275380
		leucine-rich repeat	572..596	CDD:275380
		LRR_RI	<574..>678	CDD:238064
		LRR_8	595..655	CDD:290566
		leucine-rich repeat	597..620	CDD:275380
		leucine-rich repeat	621..644	CDD:275380
		leucine-rich repeat	645..668	CDD:275380
		leucine-rich repeat	669..756	CDD:275380
		LRRCT	677..726	CDD:214507
		LRRNT	739..770	CDD:214470
		leucine-rich repeat	757..791	CDD:275380
		LRR_4	770..807	CDD:289563
		LRR_8	790..850	CDD:290566
		LRR_4	791..830	CDD:289563
		leucine-rich repeat	792..815	CDD:275380
		LRR_4	814..863	CDD:289563
		leucine-rich repeat	816..839	CDD:275380
		leucine-rich repeat	840..861	CDD:275380
		LRRCT	872..920	CDD:214507
		EGF	935..966	CDD:278437
		EGF_CA	971..1007	CDD:238011
		EGF_CA	1009..1045	CDD:238011
		EGF_CA	1055..1086	CDD:238011
		EGF_CA	1088..1124	CDD:238011
		Laminin_G_1	1204..1335	CDD:278483
		CT	1435..1504	CDD:214482
LRRC55	NP_001005210.2	PLN00113	<47..>201	CDD:331614	43/153 (28%)
		leucine-rich repeat	47..66	CDD:275380	9/18 (50%)
		LRR 1	66..87		9/20 (45%)
		leucine-rich repeat	67..90	CDD:275380	8/22 (36%)
		LRR_8	90..148	CDD:316378	14/57 (25%)
		LRR 2	90..111		5/20 (25%)
		leucine-rich repeat	91..114	CDD:275380	5/22 (23%)
		LRR 3	114..135		6/20 (30%)
		leucine-rich repeat	115..138	CDD:275380	6/22 (27%)
		LRR 4	138..160		5/21 (24%)
		leucine-rich repeat	139..163	CDD:275380	6/23 (26%)
		LRR 5	163..186		4/22 (18%)
		leucine-rich repeat	164..187	CDD:275380	4/22 (18%)
		TPKR_C2	196..247	CDD:326558	14/50 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910