DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sli and Lrtm2

DIOPT Version :9

Sequence 1:	NP_001261017.1	Gene:	sli / 36746	FlyBaseID:	FBgn0264089	Length:	2157	Species:	Drosophila melanogaster
Sequence 2:	NP_001165678.1	Gene:	Lrtm2 / 211187	MGIID:	2141485	Length:	370	Species:	Mus musculus

Alignment Length:	295	Identity:	87/295 - (29%)
Similarity:	131/295 - (44%)	Gaps:	61/295 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 PGGG-------------------------VGVITEARCPRVCSC--TGLNVDCSHRGLTSVPRKI 98
            ||||                         |.||  ..||..|:|  ..|.||||..|||:||..:
Mouse     4 PGGGPEQRSKLVLQWRQVSWITCWIALCAVEVI--PACPFSCTCDSRSLEVDCSGLGLTTVPPDV 66

  Fly    99 SADVERLELQGNNLTVIYETDFQRLTKLRMLQLTDNQIHTIERNSFQDLVSLERLRLNNNRLKAI 163
            .|..:.|.|..|.|:.:....|..|:.|:.|.|::|.:..:.|:.|:|||:|..|:|.||.::.:
Mouse    67 PAATQSLLLLNNKLSALPSWAFANLSNLQRLDLSNNFLDQLPRSIFEDLVNLTELQLRNNSIRTL 131

  Fly   164 PENFVTSSASLLRLDISNNVITTVGRRVFKGAQSLRSLQLDNNQITCLDEHAFKGLVELEILTLN 228
            ..:.:..|..|..||:|.|.:..:...:|.|..:||||.|.:|::..||...|:.|..|::
Mouse   132 DRDLLQHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQSLDRLTFEPLASLQL---- 192

  Fly   229 NNNLTSLPHNIFGGLGRLRALRLSDNPFACDCHL----SWLSRFLRSATRLAPYTRCQSPSQLKG 289
                                |::.|||:.|||:|    .||..|.....|| ....|..|.:|:|
Mouse   193 --------------------LQVGDNPWECDCNLREFKHWLEWFSYRGGRL-DQLACTLPKELRG 236

  Fly   290 QNVADLHDQEFK-CSGLTEHAPMECGAENSCPHPC 323
            :::..:..:.|. ||.| |......|.:...| ||
Mouse   237 KDMRAVPMEMFNYCSQL-EDENNSAGLDAPGP-PC 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sli	NP_001261017.1	LRRNT	73..103	CDD:214470	15/31 (48%)
		leucine-rich repeat	83..104	CDD:275380	10/20 (50%)
		LRR_8	102..160	CDD:290566	20/57 (35%)
		leucine-rich repeat	105..125	CDD:275380	6/19 (32%)
		LRR_RI	<119..259	CDD:238064	39/139 (28%)
		leucine-rich repeat	126..149	CDD:275380	8/22 (36%)
		LRR_8	149..208	CDD:290566	19/58 (33%)
		leucine-rich repeat	150..173	CDD:275380	6/22 (27%)
		leucine-rich repeat	174..197	CDD:275380	7/22 (32%)
		LRR_8	197..256	CDD:290566	14/58 (24%)
		leucine-rich repeat	198..221	CDD:275380	10/22 (45%)
		leucine-rich repeat	222..245	CDD:275380	1/22 (5%)
		leucine-rich repeat	246..371	CDD:275380	26/83 (31%)
		LRRCT	254..303	CDD:214507	16/53 (30%)
		LRRNT	319..350	CDD:214470	3/5 (60%)
		LRR_8	349..406	CDD:290566
		LRR_4	371..411	CDD:289563
		leucine-rich repeat	372..395	CDD:275380
		leucine-rich repeat	396..415	CDD:275380
		leucine-rich repeat	420..443	CDD:275380
		leucine-rich repeat	444..465	CDD:275380
		leucine-rich repeat	468..480	CDD:275378
		LRRCT	476..525	CDD:214507
		leucine-rich repeat	484..545	CDD:275380
		LRRNT	542..574	CDD:214470
		leucine-rich repeat	552..570	CDD:275380
		leucine-rich repeat	572..596	CDD:275380
		LRR_RI	<574..>678	CDD:238064
		LRR_8	595..655	CDD:290566
		leucine-rich repeat	597..620	CDD:275380
		leucine-rich repeat	621..644	CDD:275380
		leucine-rich repeat	645..668	CDD:275380
		leucine-rich repeat	669..756	CDD:275380
		LRRCT	677..726	CDD:214507
		LRRNT	739..770	CDD:214470
		leucine-rich repeat	757..791	CDD:275380
		LRR_4	770..807	CDD:289563
		LRR_8	790..850	CDD:290566
		LRR_4	791..830	CDD:289563
		leucine-rich repeat	792..815	CDD:275380
		LRR_4	814..863	CDD:289563
		leucine-rich repeat	816..839	CDD:275380
		leucine-rich repeat	840..861	CDD:275380
		LRRCT	872..920	CDD:214507
		EGF	935..966	CDD:278437
		EGF_CA	971..1007	CDD:238011
		EGF_CA	1009..1045	CDD:238011
		EGF_CA	1055..1086	CDD:238011
		EGF_CA	1088..1124	CDD:238011
		Laminin_G_1	1204..1335	CDD:278483
		CT	1435..1504	CDD:214482
Lrtm2	NP_001165678.1	LRRNT	38..67	CDD:396168	14/28 (50%)
		leucine-rich repeat	51..93	CDD:275378	16/41 (39%)
		LRR 1	69..90		5/20 (25%)
		LRR_8	92..152	CDD:404697	20/59 (34%)
		LRR 2	93..114		6/20 (30%)
		leucine-rich repeat	94..117	CDD:275378	8/22 (36%)
		LRR 3	117..138		5/20 (25%)
		leucine-rich repeat	118..141	CDD:275378	6/22 (27%)
		LRR 4	141..162		6/20 (30%)
		leucine-rich repeat	142..189	CDD:275378	17/46 (37%)
		LRR 5	165..186		9/20 (45%)
		leucine-rich repeat	166..186	CDD:275380	9/19 (47%)
		leucine-rich repeat	190..202	CDD:275378	5/35 (14%)
		TPKR_C2	198..247	CDD:417692	15/49 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..297		4/11 (36%)
		Herpes_glycop_D	<261..335	CDD:421518	4/10 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	351..370
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45836
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010