DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sli and Slit3

DIOPT Version :9

Sequence 1:NP_001261017.1 Gene:sli / 36746 FlyBaseID:FBgn0264089 Length:2157 Species:Drosophila melanogaster
Sequence 2:NP_035542.2 Gene:Slit3 / 20564 MGIID:1315202 Length:1523 Species:Mus musculus


Alignment Length:1505 Identity:648/1505 - (43%)
Similarity:914/1505 - (60%) Gaps:93/1505 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 ARCPRVCSCTGLNVDCSHRGLTSVPRKISADVERLELQGNNLTVIYETDFQRLTKLRMLQLTDNQ 135
            |.||..|:|:..:|||...||.:|||.|..:.|||:|..||:|.|.:.||..|..||:|.|.|||
Mouse    32 AACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQ 96

  Fly   136 IHTIERNSFQDLVSLERLRLNNNRLKAIPENFVTSSASLLRLDISNNVITTVGRRVFKGAQSLRS 200
            :..|||.:||||..|||||||.|:|:.:||....|:..|.|||:|.|.|..:.|:.|:|...:::
Mouse    97 VSIIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGVTGVKN 161

  Fly   201 LQLDNNQITCLDEHAFKGLVELEILTLNNNNLTSLPHNIFGGLGRLRALRLSDNPFACDCHLSWL 265
            ||||||.|:|:::.||:.|.:||||||||||::.:....|..:.::|.|||..|...|||||:||
Mouse   162 LQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWL 226

  Fly   266 SRFLRSATRLAPYTRCQSPSQLKGQNVADLHDQEFKCSGLTEHAPMECGAEN-SCPHPCRCADGI 329
            |.:||....:..:|.|.:|..|:|.:|||:..:|:.|.|....|| .|.|.: |||..|.|::.|
Mouse   227 SDWLRQRRTIGQFTLCMAPVHLRGFSVADVQKKEYVCPGPHSEAP-ACNANSLSCPSACSCSNNI 290

  Fly   330 VDCREKSLTSVPVTLPDDTTELRLEQNFITELPPKSFSSFRRLRRIDLSNNNISRIAHDALSGLK 394
            ||||.|.||.:|..||:...|:|||||.|..:|..:|:.:::|:|||:|.|.||.||.||..|||
Mouse   291 VDCRGKGLTEIPANLPEGIVEIRLEQNSIKSIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLK 355

  Fly   395 QLTTLVLYGNKIKDLPSGVFKGLGSLQLLLLNANEISCIRKDAFRDLHSLSLLSLYDNNIQSLAN 459
            .||:||||||||.::|.|:|.||.||||||||||:|:|:|.:.|:||.:|:|||||||.:|:::.
Mouse   356 SLTSLVLYGNKITEIPKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISK 420

  Fly   460 GTFDAMKSIKTVHLAKNPFICDCNLRWLADYLHKNPIETSGARCESPKRMHRRRIESLREEKFKC 524
            |.|..::||:|:|||:|||:|||:|:||||||..||||||||||.||:|:..:||..::.:||:|
Mouse   421 GLFVPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKSKKFRC 485

  Fly   525 SWDE-LRMKLSGECRMDSDCPAMCHCEGTTVDCTGRGLKEIPRDIPLHTTELLLNDNELGRISSD 588
            |..| .|.:.|.||.||..||..|.||||.|||:.:.|..||..:|.:||:|.||||::..:.:.
Mouse   486 SGSEDYRNRFSSECFMDLVCPEKCRCEGTIVDCSNQKLARIPSHLPEYTTDLRLNDNDISVLEAT 550

  Fly   589 GLFGRLPHLVKLELKRNQLTGIEPNAFEGASHIQELQLGENKIKEISNKMFLGLHQLKT------ 647
            |:|.:||:|.|:.|..|::..:...||:||:.:|||.|..|:::.:..:||.||..|||      
Mouse   551 GIFKKLPNLRKINLSNNRIKEVREGAFDGAAGVQELMLTGNQLETMHGRMFRGLSSLKTLMLRSN 615

  Fly   648 ------------------LNLYDNQISCVMPGSFEHLNSLTSLNLASNPFNCNCHLAWFAEWLRK 694
                              |:||||:|:.:.||:|..|.||:::||.|||||||||:||...||||
Mouse   616 LISCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHMAWLGRWLRK 680

  Fly   695 KSLNGGAARCGAPSKVRDVQIKDLPHSEFKCSSENSEGCLGDGYCPPSCTCTGTVVRCSRNQLKE 759
            :.:..|..||..|..::::.|:|:...:|.|.......|.....||..|||..||||||...|..
Mouse   681 RRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCVETVVRCSNRGLHA 745

  Fly   760 IPRGIPAETSELYLESNEIEQIHYERIRHLRSLTRLDLSNNQITILSNYTFANLTKLSTLIISYN 824
            :|:|:|.:.:|||||.|.:..:..| :...|.||.:|||||.|::|:|:||:|::.|||||:|||
Mouse   746 LPKGMPKDVTELYLEGNHLTAVPKE-LSAFRQLTLIDLSNNSISMLTNHTFSNMSHLSTLILSYN 809

  Fly   825 KLQCLQRHALSGLNNLRVLSLHGNRISMLPEGSFEDLKSLTHIALGSNPLYCDCGLKWFSDWIKL 889
            :|:|:..||.:||.:||||:||||.||.:|||||.||.||:|:|||:|||:|||.|:|.|:|:|.
Mouse   810 RLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVKA 874

  Fly   890 DYVEPGIARCAEPEQMKDKLILSTPSSSFVCRGRVRNDILAKCNACFEQPCQNQAQCVALPQREY 954
            .|.|||||||:.||.|.|:|:|:||:..|.|:|.|..:|:||||||...||:|...|...|..:|
Mouse   875 GYKEPGIARCSSPESMADRLLLTTPTHRFQCKGPVDINIVAKCNACLSSPCKNNGTCSQDPVEQY 939

  Fly   955 QCLCQPGYHGKHCEFMIDACYGNPCRNNATCTVLEEGR--FSCQCAPGYTGARCETNIDDCLGEI 1017
            :|.|...|.||.|...|:.|..|||.:..||.:.|..|  |||.|..|:.|.|||.|.||| .:.
Mouse   940 RCTCPYSYKGKDCTVPINTCVQNPCEHGGTCHLSENLRDGFSCSCPLGFEGQRCEINPDDC-EDN 1003

  Fly  1018 KCQNNATCIDGVESYKCECQPGFSGEFCDTKIQFCSPEFNPCANGAKCMDHFTHYSCDCQAGFHG 1082
            .|:|:|||:||:.:|.|.|.|.::||.||..|.:|.||.|.|.:.|||:.....:.|:|..|:.|
Mouse  1004 DCENSATCVDGINNYACLCPPNYTGELCDEVIDYCVPEMNLCQHEAKCISLDKGFRCECVPGYSG 1068

  Fly  1083 TNCTDNIDDCQNHMCQNGGTCVDGINDYQCRCPDDYTGKYCEGHNMISMMYPQTSPCQNHECKHG 1147
            ..|..|.|||..|.|::|..|||.:|.|.|.||..::|.:||  :...|:..|||||..:||::|
Mouse  1069 KLCETNNDDCVAHKCRHGAQCVDEVNGYTCICPQGFSGLFCE--HPPPMVLLQTSPCDQYECQNG 1131

  Fly  1148 V-CFQPNAQGSDYLCRCHPGYTGKWCEYLTSISFVHNNSFVELEPLRTRPEANVTIVFSSAEQNG 1211
            . |.....:.:   |||.||:.|..||.|.:::||..:|:|||...:.||:||:::..::.:.||
Mouse  1132 AQCIVVQQEPT---CRCPPGFAGPRCEKLITVNFVGKDSYVELASAKVRPQANISLQVATDKDNG 1193

  Fly  1212 ILMYDGQDAHLAVELFNGRIRVSYDVGNHPVSTMYSFEMVADGKYHAVELLAIKKNFTLRVDRGL 1276
            ||:|.|.:..||:||:.|.:|:.||..:.|.:|:||.|.|.||::|:|||:.:.:...|.||:|.
Mouse  1194 ILLYKGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVMLNQTLNLVVDKGA 1258

  Fly  1277 ARSIINEGSNDYLKLTTPMFLGGLPVDPAQQAYKNWQIRNLTSFKGCMKEVWINHKLVDFGNAQR 1341
            .:|:........:...:|::|||:|......|.:....|.|..|.||:.||.||::|.||.....
Mouse  1259 PKSLGKLQKQPAVGSNSPLYLGGIPTSTGLSALRQGADRPLGGFHGCIHEVRINNELQDFKALPP 1323

  Fly  1342 QQ-KITPGC----ALLEGEQQEEEDDEQDFMDET------PHIKEEPVDPCLENKCRRGSRCVPN 1395
            |. .::|||    ....|..:..|.|  ..:.|.      |...:|..||||.:.||.|: |:..
Mouse  1324 QSLGVSPGCKSCTVCRHGLCRSVEKD--SVVCECHPGWTGPLCDQEARDPCLGHSCRHGT-CMAT 1385

  Fly  1396 SNARDGYQCKCKHGQRGRYCDQGEGSTEPPTVTAASTCRKEQVR-----EYY------------- 1442
            .   |.|.|||..|..|..|||...|.   :..:|..|...|..     |.|             
Mouse  1386 G---DSYVCKCAEGYGGALCDQKNDSA---SACSAFKCHHGQCHISDRGEPYCLCQPGFSGHHCE 1444

  Fly  1443 TENDCRS-------RQPLKYAKCV-----------GGCGNQCCAAKIVRRRKVRMVCSNNRKYIK 1489
            .||.|..       |:...||.|.           ||||:|||.....:|||....|::...:::
Mouse  1445 QENPCMGEIVREAIRRQKDYASCATASKVPIMECRGGCGSQCCQPIRSKRRKYVFQCTDGSSFVE 1509

  Fly  1490 NLDIVRKCGC 1499
            .::...:|||
Mouse  1510 EVERHLECGC 1519

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sliNP_001261017.1 LRRNT 73..103 CDD:214470 13/29 (45%)
leucine-rich repeat 83..104 CDD:275380 9/20 (45%)
LRR_8 102..160 CDD:290566 33/57 (58%)
leucine-rich repeat 105..125 CDD:275380 9/19 (47%)
LRR_RI <119..259 CDD:238064 66/139 (47%)
leucine-rich repeat 126..149 CDD:275380 14/22 (64%)
LRR_8 149..208 CDD:290566 28/58 (48%)
leucine-rich repeat 150..173 CDD:275380 12/22 (55%)
leucine-rich repeat 174..197 CDD:275380 10/22 (45%)
LRR_8 197..256 CDD:290566 27/58 (47%)
leucine-rich repeat 198..221 CDD:275380 11/22 (50%)
leucine-rich repeat 222..245 CDD:275380 11/22 (50%)
leucine-rich repeat 246..371 CDD:275380 55/125 (44%)
LRRCT 254..303 CDD:214507 20/48 (42%)
LRRNT 319..350 CDD:214470 15/30 (50%)
LRR_8 349..406 CDD:290566 32/56 (57%)
LRR_4 371..411 CDD:289563 25/39 (64%)
leucine-rich repeat 372..395 CDD:275380 14/22 (64%)
leucine-rich repeat 396..415 CDD:275380 12/18 (67%)
leucine-rich repeat 420..443 CDD:275380 15/22 (68%)
leucine-rich repeat 444..465 CDD:275380 11/20 (55%)
leucine-rich repeat 468..480 CDD:275378 8/11 (73%)
LRRCT 476..525 CDD:214507 30/48 (63%)
leucine-rich repeat 484..545 CDD:275380 34/61 (56%)
LRRNT 542..574 CDD:214470 15/31 (48%)
leucine-rich repeat 552..570 CDD:275380 7/17 (41%)
leucine-rich repeat 572..596 CDD:275380 10/23 (43%)
LRR_RI <574..>678 CDD:238064 44/127 (35%)
LRR_8 595..655 CDD:290566 26/83 (31%)
leucine-rich repeat 597..620 CDD:275380 8/22 (36%)
leucine-rich repeat 621..644 CDD:275380 9/22 (41%)
leucine-rich repeat 645..668 CDD:275380 13/46 (28%)
leucine-rich repeat 669..756 CDD:275380 38/86 (44%)
LRRCT 677..726 CDD:214507 21/48 (44%)
LRRNT 739..770 CDD:214470 15/30 (50%)
leucine-rich repeat 757..791 CDD:275380 11/33 (33%)
LRR_4 770..807 CDD:289563 17/36 (47%)
LRR_8 790..850 CDD:290566 36/59 (61%)
LRR_4 791..830 CDD:289563 23/38 (61%)
leucine-rich repeat 792..815 CDD:275380 13/22 (59%)
LRR_4 814..863 CDD:289563 31/48 (65%)
leucine-rich repeat 816..839 CDD:275380 14/22 (64%)
leucine-rich repeat 840..861 CDD:275380 15/20 (75%)
LRRCT 872..920 CDD:214507 28/47 (60%)
EGF 935..966 CDD:278437 11/30 (37%)
EGF_CA 971..1007 CDD:238011 16/37 (43%)
EGF_CA 1009..1045 CDD:238011 17/35 (49%)
EGF_CA 1055..1086 CDD:238011 10/30 (33%)
EGF_CA 1088..1124 CDD:238011 16/35 (46%)
Laminin_G_1 1204..1335 CDD:278483 47/130 (36%)
CT 1435..1504 CDD:214482 24/101 (24%)
Slit3NP_035542.2 LRRNT 33..60 CDD:279764 12/26 (46%)
LRR_RI <49..220 CDD:238064 80/170 (47%)
LRR_8 61..121 CDD:290566 33/59 (56%)
LRR 1 62..83 10/20 (50%)
leucine-rich repeat 64..86 CDD:275380 11/21 (52%)
LRR 2 86..107 11/20 (55%)
leucine-rich repeat 87..110 CDD:275380 14/22 (64%)
LRR_8 109..169 CDD:290566 28/59 (47%)
LRR 3 110..131 11/20 (55%)
leucine-rich repeat 111..134 CDD:275380 12/22 (55%)
LRR 4 134..155 9/20 (45%)
leucine-rich repeat 135..158 CDD:275380 10/22 (45%)
LRR_8 157..217 CDD:290566 27/59 (46%)
LRR 5 158..179 10/20 (50%)
leucine-rich repeat 159..182 CDD:275380 11/22 (50%)
LRR 6 182..203 11/20 (55%)
leucine-rich repeat 183..206 CDD:275380 11/22 (50%)
leucine-rich repeat 207..309 CDD:275380 46/102 (45%)
LRRNT 280..311 CDD:214470 15/30 (50%)
LRR 7 308..329 9/20 (45%)
LRR_8 311..367 CDD:290566 32/55 (58%)
leucine-rich repeat 311..332 CDD:275380 9/20 (45%)
LRR_4 331..371 CDD:289563 25/39 (64%)
LRR 8 332..353 12/20 (60%)
leucine-rich repeat 333..356 CDD:275380 14/22 (64%)
LRR_8 355..439 CDD:290566 50/83 (60%)
LRR 9 356..377 13/20 (65%)
leucine-rich repeat 357..377 CDD:275380 13/19 (68%)
LRR 10 380..401 14/20 (70%)
leucine-rich repeat 381..404 CDD:275380 15/22 (68%)
LRR 11 404..425 11/20 (55%)
leucine-rich repeat 405..426 CDD:275380 11/20 (55%)
leucine-rich repeat 429..522 CDD:275380 54/92 (59%)
TPKR_C2 437..>467 CDD:301599 23/29 (79%)
LRRNT 505..535 CDD:214470 14/29 (48%)
LRR 12 533..554 8/20 (40%)
leucine-rich repeat 534..558 CDD:275380 10/23 (43%)
LRR_4 535..574 CDD:289563 14/38 (37%)
LRR_8 557..617 CDD:290566 21/59 (36%)
LRR 13 558..579 6/20 (30%)
leucine-rich repeat 559..582 CDD:275380 8/22 (36%)
LRR 14 582..603 7/20 (35%)
leucine-rich repeat 583..606 CDD:275380 9/22 (41%)
LRR_8 605..665 CDD:290566 19/59 (32%)
LRR 15 606..627 3/20 (15%)
leucine-rich repeat 607..630 CDD:275380 3/22 (14%)
LRR 16 630..651 9/20 (45%)
leucine-rich repeat 631..654 CDD:275380 10/22 (45%)
leucine-rich repeat 655..745 CDD:275380 39/89 (44%)
LRRCT 663..712 CDD:214507 21/48 (44%)
LRRNT 725..756 CDD:214470 15/30 (50%)
leucine-rich repeat 746..776 CDD:275380 10/30 (33%)
LRR_RI <751..869 CDD:238064 67/118 (57%)
LRR 17 753..774 7/21 (33%)
LRR_8 775..835 CDD:290566 36/59 (61%)
LRR 18 776..797 12/20 (60%)
leucine-rich repeat 777..800 CDD:275380 13/22 (59%)
LRR 19 800..821 12/20 (60%)
leucine-rich repeat 801..824 CDD:275380 14/22 (64%)
LRR 20 824..845 15/20 (75%)
leucine-rich repeat 825..846 CDD:275380 15/20 (75%)
LRRCT 857..906 CDD:214507 28/48 (58%)
EGF_CA 956..994 CDD:238011 16/37 (43%)
EGF_CA 998..1031 CDD:238011 16/33 (48%)
EGF_CA 1035..1072 CDD:238011 13/36 (36%)
EGF_CA 1076..1110 CDD:238011 15/33 (45%)
EGF 1123..1153 CDD:278437 11/32 (34%)
Laminin_G_2 1188..1314 CDD:280389 46/125 (37%)
GHB_like 1463..1519 CDD:304424 15/55 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 124 1.000 Domainoid score I5492
eggNOG 1 0.900 - - E2759_KOG4237
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1356 1.000 Inparanoid score I137
Isobase 1 0.950 - 0 Normalized mean entropy S3289
OMA 1 1.010 - - QHG45950
OrthoDB 1 1.010 - - D20003at33208
OrthoFinder 1 1.000 - - FOG0001593
OrthoInspector 1 1.000 - - otm42612
orthoMCL 1 0.900 - - OOG6_103623
Panther 1 1.100 - - O PTHR45836
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3290
SonicParanoid 1 1.000 - - X1145
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1514.820

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