DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sli and Slit1

DIOPT Version :9

Sequence 1:	NP_001261017.1	Gene:	sli / 36746	FlyBaseID:	FBgn0264089	Length:	2157	Species:	Drosophila melanogaster
Sequence 2:	NP_056563.2	Gene:	Slit1 / 20562	MGIID:	1315203	Length:	1531	Species:	Mus musculus

Alignment Length:	1521	Identity:	658/1521 - (43%)
Similarity:	928/1521 - (61%)	Gaps:	117/1521 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 CPRVCSCTGLNVDCSHRGLTSVPRKISADVERLELQGNNLTVIYETDFQRLTKLRMLQLTDNQIH 137
            ||.:|:|||..|||...||.::|:.|..:.|||||.|||:|.|::.||..|.:||:|||.:|||.
Mouse    34 CPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIG 98

  Fly   138 TIERNSFQDLVSLERLRLNNNRLKAIPENFVTSSASLLRLDISNNVITTVGRRVFKGAQSLRSLQ 202
            .:||.:|.|:..|||||||.|:|:.:||....::.:|.|||:|.|.:..|.|:.|:||..|::||
Mouse    99 AVERGAFDDMKELERLRLNRNQLQVLPELLFQNNQALSRLDLSENFLQAVPRKAFRGATDLKNLQ 163

  Fly   203 LDNNQITCLDEHAFKGLVELEILTLNNNNLTSLPHNIFGGLGRLRALRLSDNPFACDCHLSWLSR 267
            ||.|:|:|::|.||:.|..||:|||||||:|::|.:.|..:.:||..||..|...|||||:|||:
Mouse   164 LDKNRISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQ 228

  Fly   268 FLRSATRLAPYTRCQSPSQLKGQNVADLHDQEFKCSGLTE--HAPMECGAENSCPHPCRCADGIV 330
            :||....:..:|:|..|:.|:|.|||::...||.|||..|  .||....:..|||..|.|:.|||
Mouse   229 WLRQRPTIGLFTQCSGPASLRGLNVAEVQKGEFSCSGQGEAAGAPACTLSSGSCPAMCSCSSGIV 293

  Fly   331 DCREKSLTSVPVTLPDDTTELRLEQNFITELPPKSFSSFRRLRRIDLSNNNISRIAHDALSGLKQ 395
            |||.|.||::|..||:..||:|||.|.|..:||.:||.:|:|||||||||.|:.||.||..||:.
Mouse   294 DCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRS 358

  Fly   396 LTTLVLYGNKIKDLPSGVFKGLGSLQLLLLNANEISCIRKDAFRDLHSLSLLSLYDNNIQSLANG 460
            |.:||||||||.|||.|||.||.:|||||||||:|:|||.|||:||.:|||||||||.|||||.|
Mouse   359 LNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKG 423

  Fly   461 TFDAMKSIKTVHLAKNPFICDCNLRWLADYLHKNPIETSGARCESPKRMHRRRIESLREEKFKCS 525
            ||.::::|:|:|||:|||||||||:||||:|..|||||:||||.||:|:..:||..::.:||:||
Mouse   424 TFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETTGARCASPRRLANKRIGQIKSKKFRCS 488

  Fly   526 WDELRM-------KLSGECRMDSDCPAMCHCEGTTVDCTGRGLKEIPRDIPLHTTELLLNDNELG 583
            ..|...       .|:.||..|..||..|.||.:.|:|:...|.:||..||..||||.||:||:.
Mouse   489 AKEQYFIPGTEDYHLNSECTSDVACPHKCRCEASVVECSSLKLSKIPERIPQSTTELRLNNNEIS 553

  Fly   584 RISSDGLFGRLPHLVKLELKRNQLTGIEPNAFEGASHIQELQLGENKIKEISNKMFLGLHQLKT- 647
            .:.:.|||.:|.||.|:.|..|:::.||...||||:.:.||.|..|:::.|.:.||.||..|:|
Mouse   554 ILEATGLFKKLSHLKKINLSNNKVSEIEDGTFEGAASVSELHLTANQLESIRSGMFRGLDGLRTL 618

  Fly   648 -----------------------LNLYDNQISCVMPGSFEHLNSLTSLNLASNPFNCNCHLAWFA 689
                                   |:||||.|:.:.||:|:.|.:|::|||.:|||||||||:|..
Mouse   619 MLRNNRISCIHNDSFTGLRNVRLLSLYDNHITTISPGAFDTLQALSTLNLLANPFNCNCHLSWLG 683

  Fly   690 EWLRKKSLNGGAARCGAPSKVRDVQIKDLPHSEFKCSSENSE-GCLGDGYCPPSCTCTGTVVRCS 753
            :||||:.:..|..||..|..:|.:.::|:...:|:|.....| |||....||..|.|..||||||
Mouse   684 DWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEVGCLPRPQCPQECACLDTVVRCS 748

  Fly   754 RNQLKEIPRGIPAETSELYLESNEIEQIHYERIRHLRSLTRLDLSNNQITILSNYTFANLTKLST 818
            ...|:.:|:|||...:||||:.|:...:. .::...:.|..:|||||:|:.|||.:|.|:::|:|
Mouse   749 NKHLQALPKGIPKNVTELYLDGNQFTLVP-GQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTT 812

  Fly   819 LIISYNKLQCLQRHALSGLNNLRVLSLHGNRISMLPEGSFEDLKSLTHIALGSNPLYCDCGLKWF 883
            ||:|||.|||:...|..||.:||:||||||.:|.|.||.|.|:.||:|:|:|:|||||||.|:|.
Mouse   813 LILSYNALQCIPPLAFQGLRSLRLLSLHGNDVSTLQEGIFADVTSLSHLAIGANPLYCDCRLRWL 877

  Fly   884 SDWIKLDYVEPGIARCAEPEQMKDKLILSTPSSSFVCRGRVRNDILAKCNACFEQPCQNQAQCVA 948
            |.|:|..|.||||||||.|.:|:.||:|:||:..|.|:|.....:.|||:.|...|||||..|..
Mouse   878 SSWVKTGYKEPGIARCAGPPEMEGKLLLTTPAKKFECQGPPSLAVQAKCDPCLSSPCQNQGTCHN 942

  Fly   949 LPQREYQCLCQPGYHGKHCEFMIDACYGNPCRNNATCTVL--EEGRFSCQCAPGYTGARCETNID 1011
            .|...|:|.|..||.|:|||..:|.|..|||.|..||...  |:..|:|.|..|:.|..|..:.|
Mouse   943 DPLEVYRCTCPSGYKGRHCEVSLDGCSSNPCGNGGTCHAQEGEDAGFTCSCPSGFEGPTCGVDTD 1007

  Fly  1012 DCLGEIKCQNNATCIDGVESYKCECQPGFSGEFCDTKIQFCSPEFNPCANGAKCMDHFTHYSCDC 1076
            ||: :..|.|...|:|||.:|.|:|...::|..|:..:.||||:.|||.:.|:|:.......|:|
Mouse  1008 DCV-KHACVNGGVCVDGVGNYTCQCPLQYTGRACEQLVDFCSPDMNPCQHEAQCVGTPDGPRCEC 1071

  Fly  1077 QAGFHGTNCTDNIDDCQNHMCQNGGTCVDGINDYQCRCPDDYTGKYCEGHNMISMMYPQT--SPC 1139
            ..|:.|.||::|.|||::|.||||..|||.:|.|.|.|.:.|:|:.||        .|..  |.|
Mouse  1072 MLGYTGDNCSENQDDCKDHKCQNGAQCVDEVNSYACLCVEGYSGQLCE--------IPPAPRSSC 1128

  Fly  1140 QNHECKHGV-CFQPNAQGSDYLCRCHPGYTGKWCEYLTSISFVHNNSFVELEPLRTRPEANVTIV 1203
            :..||::|. |..   |||..:|:|.||:.|..||.|.|::||..:::::...|:..|.||:|:.
Mouse  1129 EGTECQNGANCVD---QGSRPVCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPRANITLQ 1190

  Fly  1204 FSSAEQNGILMYDGQDAHLAVELFNGRIRVSYDVGNHPVSTMYSFEMVADGKYHAVELLAIKKNF 1268
            .|:||.||||:|:|.:.|:||||:.|.:|||||.|::|.|.:||.|.:.||::|.|||:...:..
Mouse  1191 VSTAEDNGILLYNGDNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVTFDQMV 1255

  Fly  1269 TLRVDRGLARSIINEGSNDYLKLTTPMFLGGLPVDPAQQAYKNWQIRNLTSFKGCMKEVWINHKL 1333
            .|.:|.|...::.|.|.:..|....|:::||:|||....|::.|||.|.|||.||::.::||::|
Mouse  1256 NLSIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVNSAAFRLWQILNGTSFHGCIRNLYINNEL 1320

  Fly  1334 VDFGNAQRQQKITPGCA------LLEGEQQEEEDDEQDFMDETP----HIK--------EEPVD- 1379
            .||...|.:..:.|||.      .|.|..|.         :.||    |.:        ::|||
Mouse  1321 QDFTKTQMKPGVVPGCEPCRKLYCLHGICQP---------NATPGPVCHCEAGWGGLHCDQPVDG 1376

  Fly  1380 PCLENKCRRGSRCVPNSNARDGYQCKCKHGQRGRYCDQGEGSTEP-------------------- 1424
            ||..:||..| :|||....  .|.|:|:.|..|..|:|.....||
Mouse  1377 PCHGHKCVHG-KCVPLDAL--AYSCQCQDGYSGALCNQVGAVAEPCGGLQCLHGHCQASATKGAH 1438

  Fly  1425 ----PTVTA-----ASTCRKEQVREYYTEND----CRSRQPLKYAKCVGGC-GNQCCAAKIVRRR 1475
                |..:.     .|.||.:.||:::....    |::.:||.:.:|.|.| |..||....::||
Mouse  1439 CVCSPGFSGELCEQESECRGDPVRDFHRVQRGYAICQTTRPLSWVECRGACPGQGCCQGLRLKRR 1503

  Fly  1476 KVRMVCSNNRKYIKNLDIVRKCGCTK 1501
            |:...||:...:.:.::...||||.:
Mouse  1504 KLTFECSDGTSFAEEVEKPTKCGCAQ 1529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sli	NP_001261017.1	LRRNT	73..103	CDD:214470	13/29 (45%)
		leucine-rich repeat	83..104	CDD:275380	7/20 (35%)
		LRR_8	102..160	CDD:290566	33/57 (58%)
		leucine-rich repeat	105..125	CDD:275380	11/19 (58%)
		LRR_RI	<119..259	CDD:238064	66/139 (47%)
		leucine-rich repeat	126..149	CDD:275380	12/22 (55%)
		LRR_8	149..208	CDD:290566	28/58 (48%)
		leucine-rich repeat	150..173	CDD:275380	11/22 (50%)
		leucine-rich repeat	174..197	CDD:275380	11/22 (50%)
		LRR_8	197..256	CDD:290566	29/58 (50%)
		leucine-rich repeat	198..221	CDD:275380	12/22 (55%)
		leucine-rich repeat	222..245	CDD:275380	12/22 (55%)
		leucine-rich repeat	246..371	CDD:275380	59/126 (47%)
		LRRCT	254..303	CDD:214507	21/48 (44%)
		LRRNT	319..350	CDD:214470	16/30 (53%)
		LRR_8	349..406	CDD:290566	35/56 (63%)
		LRR_4	371..411	CDD:289563	27/39 (69%)
		leucine-rich repeat	372..395	CDD:275380	16/22 (73%)
		leucine-rich repeat	396..415	CDD:275380	14/18 (78%)
		leucine-rich repeat	420..443	CDD:275380	18/22 (82%)
		leucine-rich repeat	444..465	CDD:275380	17/20 (85%)
		leucine-rich repeat	468..480	CDD:275378	8/11 (73%)
		LRRCT	476..525	CDD:214507	30/48 (63%)
		leucine-rich repeat	484..545	CDD:275380	30/67 (45%)
		LRRNT	542..574	CDD:214470	13/31 (42%)
		leucine-rich repeat	552..570	CDD:275380	6/17 (35%)
		leucine-rich repeat	572..596	CDD:275380	12/23 (52%)
		LRR_RI	<574..>678	CDD:238064	46/127 (36%)
		LRR_8	595..655	CDD:290566	27/83 (33%)
		leucine-rich repeat	597..620	CDD:275380	10/22 (45%)
		leucine-rich repeat	621..644	CDD:275380	9/22 (41%)
		leucine-rich repeat	645..668	CDD:275380	12/46 (26%)
		leucine-rich repeat	669..756	CDD:275380	40/87 (46%)
		LRRCT	677..726	CDD:214507	21/48 (44%)
		LRRNT	739..770	CDD:214470	15/30 (50%)
		leucine-rich repeat	757..791	CDD:275380	10/33 (30%)
		LRR_4	770..807	CDD:289563	13/36 (36%)
		LRR_8	790..850	CDD:290566	33/59 (56%)
		LRR_4	791..830	CDD:289563	22/38 (58%)
		leucine-rich repeat	792..815	CDD:275380	12/22 (55%)
		LRR_4	814..863	CDD:289563	27/48 (56%)
		leucine-rich repeat	816..839	CDD:275380	13/22 (59%)
		leucine-rich repeat	840..861	CDD:275380	13/20 (65%)
		LRRCT	872..920	CDD:214507	29/47 (62%)
		EGF	935..966	CDD:278437	14/30 (47%)
		EGF_CA	971..1007	CDD:238011	14/37 (38%)
		EGF_CA	1009..1045	CDD:238011	13/35 (37%)
		EGF_CA	1055..1086	CDD:238011	10/30 (33%)
		EGF_CA	1088..1124	CDD:238011	18/35 (51%)
		Laminin_G_1	1204..1335	CDD:278483	57/130 (44%)
		CT	1435..1504	CDD:214482	20/72 (28%)
Slit1	NP_056563.2	LRRNT	33..64	CDD:214470	13/29 (45%)
		leucine-rich repeat	43..62	CDD:275380	7/18 (39%)
		LRR	<62..>219	CDD:227223	76/156 (49%)
		LRR 1	62..83		12/20 (60%)
		leucine-rich repeat	63..86	CDD:275380	13/22 (59%)
		LRR 2	86..107		11/20 (55%)
		leucine-rich repeat	87..110	CDD:275380	12/22 (55%)
		LRR 3	110..131		11/20 (55%)
		leucine-rich repeat	111..134	CDD:275380	11/22 (50%)
		LRR 4	134..155		9/20 (45%)
		leucine-rich repeat	135..158	CDD:275380	11/22 (50%)
		LRR 5	158..179		11/20 (55%)
		LRR_8	159..217	CDD:338972	29/57 (51%)
		leucine-rich repeat	159..182	CDD:275380	12/22 (55%)
		LRR 6	182..203		12/20 (60%)
		leucine-rich repeat	183..206	CDD:275380	12/22 (55%)
		PCC	188..>328	CDD:188093	65/139 (47%)
		leucine-rich repeat	207..334	CDD:275380	59/126 (47%)
		LRR 7	310..331		10/20 (50%)
		internalin_A	311..>682	CDD:380193	191/370 (52%)
		LRR 8	334..355		14/20 (70%)
		leucine-rich repeat	335..358	CDD:275380	16/22 (73%)
		LRR 9	358..379		15/20 (75%)
		leucine-rich repeat	359..379	CDD:275380	15/19 (79%)
		LRR 10	382..403		16/20 (80%)
		leucine-rich repeat	383..406	CDD:275380	18/22 (82%)
		LRR 11	406..427		17/20 (85%)
		leucine-rich repeat	407..428	CDD:275380	17/20 (85%)
		leucine-rich repeat	431..528	CDD:275380	49/96 (51%)
		leucine-rich repeat	529..566	CDD:275380	17/36 (47%)
		LRR 12	541..562		10/20 (50%)
		LRR 13	566..587		8/20 (40%)
		leucine-rich repeat	567..590	CDD:275380	10/22 (45%)
		LRR 14	590..611		7/20 (35%)
		leucine-rich repeat	591..614	CDD:275380	9/22 (41%)
		LRR 15	614..635		2/20 (10%)
		leucine-rich repeat	615..638	CDD:275380	2/22 (9%)
		LRR 16	638..659		9/20 (45%)
		leucine-rich repeat	639..660	CDD:275380	9/20 (45%)
		PCC	644..>730	CDD:188093	38/85 (45%)
		leucine-rich repeat	663..754	CDD:275380	41/90 (46%)
		LRRNT	733..765	CDD:214470	15/31 (48%)
		leucine-rich repeat	755..785	CDD:275380	9/30 (30%)
		LRR_8	762..820	CDD:338972	24/58 (41%)
		LRR 17	762..783		5/21 (24%)
		LRR 18	785..806		11/20 (55%)
		leucine-rich repeat	786..809	CDD:275380	12/22 (55%)
		LRR 19	809..830		11/20 (55%)
		leucine-rich repeat	810..830	CDD:275380	11/19 (58%)
		LRR 20	833..854		13/20 (65%)
		leucine-rich repeat	834..857	CDD:275380	14/22 (64%)
		PCC	842..>1002	CDD:188093	77/159 (48%)
		EGF_CA	1005..1041	CDD:238011	13/36 (36%)
		EGF_CA	1044..1080	CDD:238011	13/35 (37%)
		EGF_CA	1085..1119	CDD:238011	17/33 (52%)
		LamG	1186..1319	CDD:214598	58/132 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	124	1.000	Domainoid score	I5492
eggNOG	1	0.900	-	-		E2759_KOG4237
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1356	1.000	Inparanoid score	I137
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45950
OrthoDB	1	1.010	-	-		D20003at33208
OrthoFinder	1	1.000	-	-		FOG0001593
OrthoInspector	1	1.000	-	-		otm42612
orthoMCL	1	0.900	-	-		OOG6_103623
Panther	1	1.100	-	-	O	PTHR45836
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3290
SonicParanoid	1	1.000	-	-		X1145
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.870