DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sli and ECM2

DIOPT Version :9

Sequence 1:	NP_001261017.1	Gene:	sli / 36746	FlyBaseID:	FBgn0264089	Length:	2157	Species:	Drosophila melanogaster
Sequence 2:	NP_001384.1	Gene:	ECM2 / 1842	HGNCID:	3154	Length:	699	Species:	Homo sapiens

Alignment Length:	428	Identity:	120/428 - (28%)
Similarity:	185/428 - (43%)	Gaps:	68/428 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 DLHDQEFKCSG----LTEHAPMECGAENS--CPHPCRCADGIVDCREKSLTSVPVTLPDDTTELR 352
            |..|:|....|    :...:|:......:  .|..|..:...:.|....||.:|.......|.|.
Human   285 DEEDEEDPVRGDMFRMPSRSPLPAPPRGTLRLPSGCSLSYRTISCINAMLTQIPPLTAPQITSLE 349

  Fly   353 LEQNFITELPPKSFSSFRRLRRIDLSNNNI--SRIAHDALSGLKQLTTLVLYGNKIKDLPSGVFK 415
            |..|.|..:|.::|:....|.|:|||.|||  |.|...|...||:|..|.:.||.:..:||.:
Human   350 LTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQL-- 412

  Fly   416 GLGSLQLLLLNANEISCIRKDAFRDLHSLSLLSLYDNNIQSLANG---TFDAMKSIKTVHLAKNP 477
             ..:|:.|.:|.|.:..|.:::..||:.|..|.|..||: |.||.   .|..:||:..:.|.||.
Human   413 -PSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNL-SEANVNPLAFKPLKSLAYLRLGKNK 475

  Fly   478 F-ICDCNLRWLAD--YLHKNPIETSGARCESPKRMHRRRIE--SLREEKFKCSWDELRMKLSGEC 537
            | |....|....:  ||..|.||.....|.:    |.|:|.  .||..|.    :|.|:
Human   476 FRIIPQGLPGSIEELYLENNQIEEITEICFN----HTRKINVIVLRYNKI----EENRI------ 526

  Fly   538 RMDSDCP-AMCHCEG-TTVDCTGRGLKEIPRDIPLHTTELLLNDNELGRISSDGLFGRL-PHLVK 599
                 .| |..:.|. .::|.:...|..:|..:|.....|:|..|::.||.. .:||.: |.|..
Human   527 -----APLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPG-YVFGHMEPGLEY 585

  Fly   600 LELKRNQLT--GIEPNAFEGASH-IQELQLGENKIKEISNKMFLGLHQLKTLN---LYDNQISCV 658
            |.|..|:|.  |::..:|.||.| ::||.|..|.:|.|..    |:.::|.|:   |.:|:|..:
Human   586 LYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPP----GIQEMKALHFLRLNNNKIRNI 646

  Fly   659 MP-----------GSFEHL----NSLTSLNLASNPFNC 681
            :|           .:.|||    |.:....:.|..|:|
Human   647 LPEEICNAEEDDDSNLEHLHLENNYIKIREIPSYTFSC 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sli	NP_001261017.1	LRRNT	73..103	CDD:214470
		leucine-rich repeat	83..104	CDD:275380
		LRR_8	102..160	CDD:290566
		leucine-rich repeat	105..125	CDD:275380
		LRR_RI	<119..259	CDD:238064
		leucine-rich repeat	126..149	CDD:275380
		LRR_8	149..208	CDD:290566
		leucine-rich repeat	150..173	CDD:275380
		leucine-rich repeat	174..197	CDD:275380
		LRR_8	197..256	CDD:290566
		leucine-rich repeat	198..221	CDD:275380
		leucine-rich repeat	222..245	CDD:275380
		leucine-rich repeat	246..371	CDD:275380	18/82 (22%)
		LRRCT	254..303	CDD:214507	3/8 (38%)
		LRRNT	319..350	CDD:214470	6/30 (20%)
		LRR_8	349..406	CDD:290566	24/58 (41%)
		LRR_4	371..411	CDD:289563	17/41 (41%)
		leucine-rich repeat	372..395	CDD:275380	12/24 (50%)
		leucine-rich repeat	396..415	CDD:275380	6/18 (33%)
		leucine-rich repeat	420..443	CDD:275380	7/22 (32%)
		leucine-rich repeat	444..465	CDD:275380	9/23 (39%)
		leucine-rich repeat	468..480	CDD:275378	4/12 (33%)
		LRRCT	476..525	CDD:214507	16/53 (30%)
		leucine-rich repeat	484..545	CDD:275380	16/65 (25%)
		LRRNT	542..574	CDD:214470	7/33 (21%)
		leucine-rich repeat	552..570	CDD:275380	3/17 (18%)
		leucine-rich repeat	572..596	CDD:275380	7/24 (29%)
		LRR_RI	<574..>678	CDD:238064	36/125 (29%)
		LRR_8	595..655	CDD:290566	22/65 (34%)
		leucine-rich repeat	597..620	CDD:275380	9/24 (38%)
		leucine-rich repeat	621..644	CDD:275380	7/22 (32%)
		leucine-rich repeat	645..668	CDD:275380	9/40 (23%)
		leucine-rich repeat	669..756	CDD:275380	3/13 (23%)
		LRRCT	677..726	CDD:214507	2/5 (40%)
		LRRNT	739..770	CDD:214470
		leucine-rich repeat	757..791	CDD:275380
		LRR_4	770..807	CDD:289563
		LRR_8	790..850	CDD:290566
		LRR_4	791..830	CDD:289563
		leucine-rich repeat	792..815	CDD:275380
		LRR_4	814..863	CDD:289563
		leucine-rich repeat	816..839	CDD:275380
		leucine-rich repeat	840..861	CDD:275380
		LRRCT	872..920	CDD:214507
		EGF	935..966	CDD:278437
		EGF_CA	971..1007	CDD:238011
		EGF_CA	1009..1045	CDD:238011
		EGF_CA	1055..1086	CDD:238011
		EGF_CA	1088..1124	CDD:238011
		Laminin_G_1	1204..1335	CDD:278483
		CT	1435..1504	CDD:214482
ECM2	NP_001384.1	VWC	103..157	CDD:278520
		Amnionless	<116..>213	CDD:317263
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..316		5/30 (17%)
		Cell attachment site. /evidence=ECO:0000255	294..296		0/1 (0%)
		NEL	<320..>572	CDD:330839	80/274 (29%)
		leucine-rich repeat	321..344	CDD:275380	4/22 (18%)
		leucine-rich repeat	345..368	CDD:275380	7/22 (32%)
		LRR 1	368..388		10/19 (53%)
		leucine-rich repeat	369..394	CDD:275380	12/24 (50%)
		LRR 2	394..415		6/23 (26%)
		leucine-rich repeat	395..415	CDD:275380	6/22 (27%)
		leucine-rich repeat	416..439	CDD:275380	7/22 (32%)
		LRR 3	416..436		5/19 (26%)
		LRR 4	439..459		8/20 (40%)
		leucine-rich repeat	440..465	CDD:275380	9/25 (36%)
		LRR 5	465..484		6/18 (33%)
		leucine-rich repeat	466..486	CDD:275380	6/19 (32%)
		LRR 6	486..507		6/24 (25%)
		leucine-rich repeat	487..510	CDD:275380	7/26 (27%)
		LRR	491..>673	CDD:227223	56/205 (27%)
		LRR 7	510..530		7/34 (21%)
		leucine-rich repeat	511..536	CDD:275380	8/39 (21%)
		LRR 8	536..557		4/20 (20%)
		LRR 9	558..578		6/20 (30%)
		LRR 10	582..602		6/19 (32%)
		leucine-rich repeat	583..606	CDD:275380	7/22 (32%)
		LRR 11	609..630		7/24 (29%)
		leucine-rich repeat	610..632	CDD:275380	7/25 (28%)
		LRR 12	632..653		5/20 (25%)
		leucine-rich repeat	633..653	CDD:275380	5/19 (26%)
		LRR 13	661..684		6/22 (27%)
		leucine-rich repeat	662..687	CDD:275380	7/23 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910