DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sli and VASN

DIOPT Version :9

Sequence 1:	NP_001261017.1	Gene:	sli / 36746	FlyBaseID:	FBgn0264089	Length:	2157	Species:	Drosophila melanogaster
Sequence 2:	NP_612449.2	Gene:	VASN / 114990	HGNCID:	18517	Length:	673	Species:	Homo sapiens

Alignment Length:	493	Identity:	122/493 - (24%)
Similarity:	192/493 - (38%)	Gaps:	96/493 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   543 CPAMCHC-EGTTVDCTGRGLKEIPRDIPLHTTELLLNDNELGRISSDGLFGRLPHLVKLELKRNQ 606
            ||:.|.| :..||.||.|....:|||:|..|..|.:.:|.:..:.: |.|..||.|..|:|.:||
Human    24 CPSGCQCSQPQTVFCTARQGTTVPRDVPPDTVGLYVFENGITMLDA-GSFAGLPGLQLLDLSQNQ 87

  Fly   607 LTGIEPNAFEGASHIQELQLGENKIKEISNKMFLGLHQLKTLNLYDNQISCVMPGSFEHLNSLTS 671
            :..:....|:..:::..|.|..|::.||:|:.|.||.:|:.|.|..|:|..:.||:|:.|:.|..
Human    88 IASLPSGVFQPLANLSNLDLTANRLHEITNETFRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLE 152

  Fly   672 LNLASNPFNCNCHLAWFAEWLRKKSLNGGAARCGAPSKVRDVQIKDLPHSEFKCSSENSEGCLGD 736
            |.|..|..                       |...|.::..:.:.||.|        ||...|..
Human   153 LKLQDNEL-----------------------RALPPLRLPRLLLLDLSH--------NSLLALEP 186

  Fly   737 GYCPPSCTCTGTVVRCSRNQLKEIPRGIPAETSELY---LESNEIEQIHYERIRHLRSLTRLDLS 798
            |...   |.....:|.:...|:::..|:.:....|:   :..|::|::. ..||.||.||||.|:
Human   187 GILD---TANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVP-PVIRGLRGLTRLRLA 247

  Fly   799 -NNQITILSNYTFANLTKLSTLIISYNKLQCLQRHALSGLNNLRVLSLHGNRISMLPEGSFEDLK 862
             |.:|..|.....|.|..|..|.:|                ||.:.:|.|:...:.|.
Human   248 GNTRIAQLRPEDLAGLAALQELDVS----------------NLSLQALPGDLSGLFPR------- 289

  Fly   863 SLTHIALGSNPLYCDCGLKWFSDWIKLDYV---EPGIARCAEPEQMKDKLILSTPSSSFVCRGRV 924
             |..:|...||..|.|.|.||..|::..:|   .|...||..|.:...:|:|....:.|.|....
Human   290 -LRLLAAARNPFNCVCPLSWFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELDYADFGCPATT 353

  Fly   925 RNDILAKCNACFEQPCQNQAQCVAL------PQREYQC-----------LCQPGYHGKHCEFMID 972
            ....:........:|....:.....      |..|...           :.||           .
Human   354 TTATVPTTRPVVREPTALSSSLAPTWLSPTEPATEAPSPPSTAPPTVGPVPQP-----------Q 407

  Fly   973 ACYGNPCRNNATCTVLEEGRFSCQCAPGYTGARCETNI 1010
            .|..:.|.|..||.:......:|.|..|:||..||:.:
Human   408 DCPPSTCLNGGTCHLGTRHHLACLCPEGFTGLYCESQM 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sli	NP_001261017.1	LRRNT	73..103	CDD:214470
		leucine-rich repeat	83..104	CDD:275380
		LRR_8	102..160	CDD:290566
		leucine-rich repeat	105..125	CDD:275380
		LRR_RI	<119..259	CDD:238064
		leucine-rich repeat	126..149	CDD:275380
		LRR_8	149..208	CDD:290566
		leucine-rich repeat	150..173	CDD:275380
		leucine-rich repeat	174..197	CDD:275380
		LRR_8	197..256	CDD:290566
		leucine-rich repeat	198..221	CDD:275380
		leucine-rich repeat	222..245	CDD:275380
		leucine-rich repeat	246..371	CDD:275380
		LRRCT	254..303	CDD:214507
		LRRNT	319..350	CDD:214470
		LRR_8	349..406	CDD:290566
		LRR_4	371..411	CDD:289563
		leucine-rich repeat	372..395	CDD:275380
		leucine-rich repeat	396..415	CDD:275380
		leucine-rich repeat	420..443	CDD:275380
		leucine-rich repeat	444..465	CDD:275380
		leucine-rich repeat	468..480	CDD:275378
		LRRCT	476..525	CDD:214507
		leucine-rich repeat	484..545	CDD:275380	1/1 (100%)
		LRRNT	542..574	CDD:214470	14/31 (45%)
		leucine-rich repeat	552..570	CDD:275380	8/17 (47%)
		leucine-rich repeat	572..596	CDD:275380	6/23 (26%)
		LRR_RI	<574..>678	CDD:238064	33/103 (32%)
		LRR_8	595..655	CDD:290566	20/59 (34%)
		leucine-rich repeat	597..620	CDD:275380	6/22 (27%)
		leucine-rich repeat	621..644	CDD:275380	9/22 (41%)
		leucine-rich repeat	645..668	CDD:275380	9/22 (41%)
		leucine-rich repeat	669..756	CDD:275380	15/86 (17%)
		LRRCT	677..726	CDD:214507	6/48 (13%)
		LRRNT	739..770	CDD:214470	4/30 (13%)
		leucine-rich repeat	757..791	CDD:275380	8/36 (22%)
		LRR_4	770..807	CDD:289563	15/40 (38%)
		LRR_8	790..850	CDD:290566	18/60 (30%)
		LRR_4	791..830	CDD:289563	13/39 (33%)
		leucine-rich repeat	792..815	CDD:275380	10/23 (43%)
		LRR_4	814..863	CDD:289563	8/48 (17%)
		leucine-rich repeat	816..839	CDD:275380	3/22 (14%)
		leucine-rich repeat	840..861	CDD:275380	4/20 (20%)
		LRRCT	872..920	CDD:214507	16/50 (32%)
		EGF	935..966	CDD:278437	5/47 (11%)
		EGF_CA	971..1007	CDD:238011	10/35 (29%)
		EGF_CA	1009..1045	CDD:238011	0/2 (0%)
		EGF_CA	1055..1086	CDD:238011
		EGF_CA	1088..1124	CDD:238011
		Laminin_G_1	1204..1335	CDD:278483
		CT	1435..1504	CDD:214482
VASN	NP_612449.2	LRR 8	217..238		5/21 (24%)
		leucine-rich repeat	218..240	CDD:275380	6/22 (27%)
		LRR 9	240..262		8/21 (38%)
		leucine-rich repeat	241..265	CDD:275380	10/23 (43%)
		LRR 10	265..287		7/37 (19%)
		leucine-rich repeat	266..286	CDD:275380	7/35 (20%)
		LRRCT	298..349	CDD:214507	16/50 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..404		3/45 (7%)
		EGF	409..440	CDD:278437	10/30 (33%)
		fn3	466..535	CDD:278470
		LRRNT	23..54	CDD:214470	13/29 (45%)
		leucine-rich repeat	34..56	CDD:275380	10/21 (48%)
		LRR 1	52..74		5/22 (23%)
		leucine-rich repeat	57..77	CDD:275380	5/20 (25%)
		LRR_8	62..112	CDD:290566	14/50 (28%)
		LRR_4	76..117	CDD:289563	12/40 (30%)
		LRR 2	77..98		6/20 (30%)
		leucine-rich repeat	78..101	CDD:275380	6/22 (27%)
		LRR_8	101..158	CDD:290566	21/56 (38%)
		LRR_4	101..141	CDD:289563	14/39 (36%)
		LRR 3	101..122		7/20 (35%)
		leucine-rich repeat	102..125	CDD:275380	9/22 (41%)
		LRR_8	124..228	CDD:290566	28/137 (20%)
		LRR 4	125..146		8/20 (40%)
		leucine-rich repeat	126..149	CDD:275380	9/22 (41%)
		LRR 5	149..170		6/43 (14%)
		leucine-rich repeat	150..193	CDD:275380	14/76 (18%)
		LRR 6	171..191		7/30 (23%)
		LRR 7	193..214		3/20 (15%)
		leucine-rich repeat	194..217	CDD:275380	3/22 (14%)
		LRR_8	216..273	CDD:290566	20/73 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910