DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8249 and HXT4

DIOPT Version :9

Sequence 1:	NP_001246349.1	Gene:	CG8249 / 36742	FlyBaseID:	FBgn0034045	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_011960.2	Gene:	HXT4 / 856492	SGDID:	S000001134	Length:	576	Species:	Saccharomyces cerevisiae

Alignment Length:	457	Identity:	103/457 - (22%)
Similarity:	198/457 - (43%)	Gaps:	72/457 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 HLNDSQASWFASVNALSAPIGGLLSGFLLDRIGRKKSLIVLNVLIILAWIL-LATPSESDQNAFF 144
            :|:..:.....|:..:...|||::...|.|..|||..|||:.|:.|:..|: :|:.::      :
Yeast   115 YLSKVRTGLIVSIFNIGCAIGGIILAKLGDMYGRKMGLIVVVVIYIIGIIIQIASINK------W 173

  Fly   145 WQLIVSRFMLGVGMGLASAPPGVYAAEISVPKTRGSLILGTSISVAGGITILYGIGYCIR----- 204
            :|..:.|.:.|:|:|..:....:..:|:|....||:|:....:.:..||.    :|||..
Yeast   174 YQYFIGRIISGLGVGGIAVLSPMLISEVSPKHIRGTLVSCYQLMITLGIF----LGYCTNYGTKT 234

  Fly   205 ----DDFRLIALICCGYQLVALLCVLPLPESHCWLLSKKRVTEAKRSLNYFRGFNKSDEITHPQV 265
                ..:|:...:...:.|..:..:..:|||..:|:...::.|||||:......:..|    |.|
Yeast   235 YTNSVQWRVPLGLGFAWALFMIGGMTFVPESPRYLVEVGKIEEAKRSIALSNKVSADD----PAV 295

  Fly   266 LEEFQLLQKSLQQRNTAVKESFWRNLH--EPEVYKPLVILMSLFAFQQLTGIFVVIVFAVQISQE 328
            :.|.:::|.:::....|...| |..:.  :.:|::.|::...:.:.|||||......:...:...
Yeast   296 MAEVEVVQATVEAEKLAGNAS-WGEIFSTKTKVFQRLIMGAMIQSLQQLTGDNYFFYYGTTVFTA 359

  Fly   329 AGIEIDPFMCAVLIGLARLITTCPMGYILEWWGRRRAGIISTLGMSVCMFLLA------------ 381
            .|:| |.|..::::|:....:|....:::|.:||||..:.....|:.||.:.|
Yeast   360 VGLE-DSFETSIVLGIVNFASTFVGIFLVERYGRRRCLLWGAASMTACMVVFASVGVTRLWPNGK 423

  Fly   382 ------GHSQIEILKEVPYLPVVAIVGFIVLSTLGLYTLPFFMISELFPQKVRGPASGLTVA--- 437
                  |.....|:....||       |...:|..  .:||.:.||.||.:|:.....:..|
Yeast   424 KNGSSKGAGNCMIVFTCFYL-------FCFATTWA--PIPFVVNSETFPLRVKSKCMAIAQACNW 479

  Fly   438 -----VGMFISFVVLKTYPGIKEYLGMSNCFIIFGVMALFALIFVYLALPETRRRTLLEIEEQFR 497
                 :|.|..|:    ...|..|.|    ::..|.: :|:..:|:..:|||:..||.|:...:.
Yeast   480 IWGFLIGFFTPFI----SGAIDFYYG----YVFMGCL-VFSYFYVFFFVPETKGLTLEEVNTLWE 535

  Fly   498 SG 499
            .|
Yeast   536 EG 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8249	NP_001246349.1	MFS	49..479	CDD:119392	96/435 (22%)
CG8249	NP_001246349.1	Sugar_tr	60..496	CDD:278511	102/452 (23%)
HXT4	NP_011960.2	Sugar_tr	74..534	CDD:395036	102/452 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342957
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	4	3.740