DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8249 and HXT17

DIOPT Version :9

Sequence 1:	NP_001246349.1	Gene:	CG8249 / 36742	FlyBaseID:	FBgn0034045	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_014470.1	Gene:	HXT17 / 855809	SGDID:	S000005355	Length:	564	Species:	Saccharomyces cerevisiae

Alignment Length:	552	Identity:	116/552 - (21%)
Similarity:	230/552 - (41%)	Gaps:	91/552 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 QNGSESNGKQARIVSGLDRLLKTPPP----------------GEQTRAVRRQVIAVIL------- 51
            |:.:||:   ..|..|.|..:...||                |:.....:|.:|..::
Yeast     2 QSSTESD---RDIQDGPDADIHVAPPVEKEWSDGFDDNEVINGDNVEPPKRGLIGYLVIYLLCYP 63

  Fly    52 ANVGVFSTGMTLAMPTATLH---------QLKDTTEPVHLNDSQASWFASVNALSAPIGGLLSGF 107
            .:.|.|..|....:....::         ..|.:|...:|::.:.....::.::...||||:...
Yeast    64 ISFGGFLPGWDSGITAGFINMDNFKMNFGSYKHSTGEYYLSNVRMGLLVAMFSIGCAIGGLIFAR 128

  Fly   108 LLDRIGRKKSLIVLNVLIILAWILLATPSESDQNAFFWQLIVSRFMLGVGMGLASAPPGVYAAEI 172
            |.|.:||:.::::: ||:.:...::...|    |..::|..|.:.:.|:|.|..|....:..:||
Yeast   129 LADTLGRRLAIVIV-VLVYMVGAIIQISS----NHKWYQYFVGKIIYGLGAGGCSVLCPMLLSEI 188

  Fly   173 SVPKTRGSLILGTSISVAGGITILYGIGYCI---------RDDFRLIALICCGYQLVALLCVLPL 228
            :....||.|:....:::..||.    :|||.         ...:|:...:|..:.|:.::.:|.:
Yeast   189 APTDLRGGLVSLYQLNMTFGIF----LGYCSVYGTRKYDNTAQWRVPLGLCFLWTLIIIIGMLLV 249

  Fly   229 PESHCWLLSKKRVTEAKRSLNYFRGFNKSDEITHPQVLEEFQLLQKS-LQQRNTAVKESFWRNLH 292
            |||..:|:..:|..||:.|:......:..|    |.||::...:... |.||.  :.|:.|:.|.
Yeast   250 PESPRYLIECERHEEARASIAKINKVSPED----PWVLKQADEINAGVLAQRE--LGEASWKELF 308

  Fly   293 --EPEVYKPLVILMSLFAFQQLTGIFVVIVFAVQISQEAGIEIDPFMCAVLIGLARLITTCPMGY 355
              :.:|.:.|:..:.:..|.||||......:...|.:..|: .|.|..::::|.....:|.....
Yeast   309 SVKTKVLQRLITGILVQTFLQLTGENYFFFYGTTIFKSVGL-TDGFETSIVLGTVNFFSTIIAVM 372

  Fly   356 ILEWWGRRRAGIISTLGMSVCMFLLAG--------HSQIEILKEVPYLPVVAIVGFIVLSTLGLY 412
            :::..|||:..:....||..||.:.|.        |.|.....:.....::....|.:......:
Yeast   373 VVDKIGRRKCLLFGAAGMMACMVIFASIGVKCLYPHGQDGPSSKGAGNAMIVFTCFYIFCFATTW 437

  Fly   413 T-LPFFMISELFPQKVRGPASGLTVA--------VGMFISFVVLKTYPGIKEYLGMSNCFIIFG- 467
            . :.:.:::|.||.||:..|..::.|        :|.|..|:.    ..|..|.|    ::..|
Yeast   438 APVAYIVVAESFPSKVKSRAMSISTACNWLWQFLIGFFTPFIT----GSIHFYYG----YVFVGC 494

  Fly   468 VMALFALIFVYLALPETRRRTLLEIEEQFRSG 499
            ::|:|  ::|:..||||...:|.||:..:..|
Yeast   495 LVAMF--LYVFFFLPETIGLSLEEIQLLYEEG 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8249	NP_001246349.1	MFS	49..479	CDD:119392	97/475 (20%)
CG8249	NP_001246349.1	Sugar_tr	60..496	CDD:278511	102/474 (22%)
HXT17	NP_014470.1	Sugar_tr	60..521	CDD:395036	104/486 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342947
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	4	3.740