DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8249 and HXT11

DIOPT Version :9

Sequence 1:	NP_001246349.1	Gene:	CG8249 / 36742	FlyBaseID:	FBgn0034045	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_014486.1	Gene:	HXT11 / 854009	SGDID:	S000005516	Length:	567	Species:	Saccharomyces cerevisiae

Alignment Length:	458	Identity:	100/458 - (21%)
Similarity:	198/458 - (43%)	Gaps:	72/458 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 HLNDSQASWFASVNALSAPIGGLLSGFLLDRIGRKKSLIVLNVLIILAWILLATPSESDQNAFFW 145
            :|:..:.....|:..:...|||::...:.|..||:..||.:..:.::..::..|....     ::
Yeast   105 YLSKVRMGLIVSIFNIGCAIGGIVLSKVGDIYGRRIGLITVTAIYVVGILIQITSINK-----WY 164

  Fly   146 QLIVSRFMLGVGMGLASAPPGVYAAEISVPKTRGSLI-----LGTSISVAGGITILYGIGYCIR- 204
            |..:.|.:.|:|:|..:....:..:|::....||:|:     :||.     ||.    :|||..
Yeast   165 QYFIGRIISGLGVGGIAVLSPMLISEVAPKHIRGTLVQLYQLMGTM-----GIF----LGYCTNY 220

  Fly   205 --------DDFRLIALICCGYQLVALLCVLPLPESHCWLLSKKRVTEAKRSLNYFRGFNKSDEIT 261
                    ..:|:...:|..:....:..::.:|||..:|:...:..||||||      :||::::
Yeast   221 GTKNYHNATQWRVGLGLCFAWATFMVSGMMFVPESPRYLIEVGKDEEAKRSL------SKSNKVS 279

  Fly   262 --HPQVLEEFQLLQKSLQQRNTAVKESFWRNL--HEPEVYKPLVILMSLFAFQQLTGIFVVIVFA 322
              .|.:|.|:..::..::....|...| |..|  .:.:|::.:::.:.:.:.|||||......:.
Yeast   280 VDDPALLVEYDTIKAGIELEKLAGNAS-WSELLSTKTKVFQRVLMGVMIQSLQQLTGDNYFFYYG 343

  Fly   323 VQISQEAGIEIDPFMCAVLIGLARLITTCPMGYILEWWGRRRAGIISTLGMSVCMFLLA------ 381
            ..|.:..|:: |.|..:::||:....::....|.:|.:|||...:.....|..|..:.|
Yeast   344 TTIFKSVGLK-DSFQTSIIIGVVNFFSSFIAVYTIERFGRRTCLLWGAASMLCCFAVFASVGVTK 407

  Fly   382 ----GHSQIEILKEVPYLPVVAIVGFIVLSTL-----GLYTLPFFMISELFPQKVRGPASGLTVA 437
                |.|..:|..:.....::....|.:.|..     |.|.:    :||.||.:|:  :.|:.:|
Yeast   408 LWPQGSSHQDITSQGAGNCMIVFTMFFIFSFATTWAGGCYVI----VSETFPLRVK--SRGMAIA 466

  Fly   438 V------GMFISFVVLKTYPGIKEYLGMSNCFIIFGVMALFALIFVYLALPETRRRTLLEIEEQF 496
            .      |..|||........|..|.|    ::..|.: :||..:|:..:|||:..||.|:...:
Yeast   467 TAANWMWGFLISFFTPFITGAINFYYG----YVFLGCL-VFAYFYVFFFVPETKGLTLEEVNTMW 526

  Fly   497 RSG 499
            ..|
Yeast   527 LEG 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8249	NP_001246349.1	MFS	49..479	CDD:119392	93/436 (21%)
CG8249	NP_001246349.1	Sugar_tr	60..496	CDD:278511	99/453 (22%)
HXT11	NP_014486.1	Sugar_tr	64..526	CDD:395036	99/453 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342997
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	4	3.740