DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8249 and HXT8

DIOPT Version :9

Sequence 1:	NP_001246349.1	Gene:	CG8249 / 36742	FlyBaseID:	FBgn0034045	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_012321.1	Gene:	HXT8 / 853216	SGDID:	S000003750	Length:	569	Species:	Saccharomyces cerevisiae

Alignment Length:	535	Identity:	112/535 - (20%)
Similarity:	219/535 - (40%)	Gaps:	84/535 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NQNGSESNGKQARIVSGLDRLLKTPPPGEQTRAVRRQVIAVILANVGVFSTGMTLAMPTATLHQL 73
            |::.||.||::|.         :...|.:...|.....|..:....|.|.:|    ..|.|:...
Yeast    39 NKDFSEYNGEEAE---------EVVVPEKPASAYATVSIMCLCMAFGGFMSG----WDTGTISGF 90

  Fly    74 KDTTE-------------PVHLNDSQASWFASVNALSAPIGGLLSGFLLDRIGRKKSLIVLNVLI 125
            .:.|:             ..:|::.:.....|:..:.:.||.|....|.|..||...||::.|:.
Yeast    91 VNQTDFLRRFGNYSHSKNTYYLSNVRTGLIVSIFNVGSAIGCLFLSKLGDIYGRCMGLIIVIVVY 155

  Fly   126 ILAWILLATPSESDQNAFFWQLIVSRFMLGVGMGLASAPPGVYAAEISVPKTRGSLILGTSISVA 190
            ::..::.....:.     ::|..:.|.:.|:|.|..|....:..:|.:....||:|:....:.|
Yeast   156 MVGIVIQIASIDK-----WYQYFIGRIIAGIGAGSISVLAPMLISETAPKHIRGTLLACWQLMV- 214

  Fly   191 GGITILYGIGYCIR---------DDFRLIALICCGYQLVALLCVLPLPESHCWLLSKKRVTEAKR 246
               |....:|||..         ..:|:...:|..:.::.:..:..:|||..:|:...::.:||.
Yeast   215 ---TFAIFLGYCTNYGTKTYSNSVQWRVPLGLCFAWAIIMIGGMTFVPESPRFLVQVGKIEQAKA 276

  Fly   247 SLNYFRGFNKSDEIT--HPQVLEEFQLLQKSLQQRNTAVKESFWRNL--HEPEVYKPLVILMSLF 307
            |      |.||::::  .|.|:.|..||...::... |:..:.|:.|  .:.:|::.|.:.:.:.
Yeast   277 S------FAKSNKLSVDDPAVVAEIDLLVAGVEAEE-AMGTASWKELFSRKTKVFQRLTMTVMIN 334

  Fly   308 AFQQLTGIFVVIVFAVQISQEAGIEIDPFMCAVLIGLARLITTCPMGYILEWWGRRRAGIISTLG 372
            :.|||||......:...|.:..|:. |.|..::::|:....:.....|.::..||||..::....
Yeast   335 SLQQLTGDNYFFYYGTTIFKSVGMN-DSFETSIVLGIVNFASCFFSLYSVDKLGRRRCLLLGAAT 398

  Fly   373 MSVCMFLLA------------------GHSQIEILKEVPYLPVVAIVGFIVLSTLGLYTLPFFMI 419
            |:.||.:.|                  |.....|:....|:       |....|.|  .:.:.:|
Yeast   399 MTACMVIYASVGVTRLYPNGKSEPSSKGAGNCTIVFTCFYI-------FCFSCTWG--PVCYVII 454

  Fly   420 SELFPQKVRGPASGLTVAVGMFISFVVLKTYPGIKEYLGMSNCFIIFGVMALFALIFVYLALPET 484
            ||.||.:||.....:..|..:...|::....|.|...:.....::..|.:| |:..:|:..:|||
Yeast   455 SETFPLRVRSKCMSVATAANLLWGFLIGFFTPFITSAINFYYGYVFMGCLA-FSYFYVFFFVPET 518

  Fly   485 RRRTLLEIEEQFRSG 499
            :..||.|::|.:..|
Yeast   519 KGLTLEEVDEMWMDG 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8249	NP_001246349.1	MFS	49..479	CDD:119392	95/473 (20%)
CG8249	NP_001246349.1	Sugar_tr	60..496	CDD:278511	100/479 (21%)
HXT8	NP_012321.1	Sugar_tr	69..530	CDD:395036	102/491 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342987
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	4	3.740