DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8249 and HXT3

DIOPT Version :9

Sequence 1:	NP_001246349.1	Gene:	CG8249 / 36742	FlyBaseID:	FBgn0034045	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_010632.1	Gene:	HXT3 / 851946	SGDID:	S000002753	Length:	567	Species:	Saccharomyces cerevisiae

Alignment Length:	550	Identity:	118/550 - (21%)
Similarity:	235/550 - (42%)	Gaps:	88/550 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DEQHQNLNQNGS------ESNGKQARIVSGLDRLLKTPPPGEQTRAVRRQVIAVILANVGVFSTG 60
            :..:.:|..|.|      |..|.|....:..|::|..|..|      :...:.|.:..|.|...|
Yeast    15 ENSNADLPSNSSQVMNMPEEKGVQDDFQAEADQVLTNPNTG------KGAYVTVSICCVMVAFGG 73

  Fly    61 MTLAMPTATL------------HQLKDTTEPVHLNDSQASWFASVNALSAPIGGLLSGFLLDRIG 113
            ......|.|:            ..:|......:|:..:.....|:..:...|||::...|.|..|
Yeast    74 FVFGWDTGTISGFVAQTDFLRRFGMKHKDGSYYLSKVRTGLIVSIFNIGCAIGGIILAKLGDMYG 138

  Fly   114 RKKSLIVLNVLIILAWIL-LATPSESDQNAFFWQLIVSRFMLGVGMGLASAPPGVYAAEISVPKT 177
            ||..|||:.|:.|:..|: :|:.::      ::|..:.|.:.|:|:|..:....:..:|::..:.
Yeast   139 RKMGLIVVVVIYIIGIIIQIASINK------WYQYFIGRIISGLGVGGIAVLSPMLISEVAPKEM 197

  Fly   178 RGSLILGTSISVAGGITILYGIGYCIR---------DDFRLIALICCGYQLVALLCVLPLPESHC 233
            ||:|:....:.:..||.    :|||..         ..:|:...:|..:.|..:..:..:|||..
Yeast   198 RGTLVSCYQLMITLGIF----LGYCTNFGTKNYSNSVQWRVPLGLCFAWALFMIGGMTFVPESPR 258

  Fly   234 WLLSKKRVTEAKRSLNYFRGFNKSDEIT--HPQVLEEFQLLQKSLQQRNTAVKESFWRNLH--EP 294
            :|:...::.||:.||      :|.:::.  ||.:.:|.::::.|:::...|...| |..|.  :|
Yeast   259 YLVEAGQIDEARASL------SKVNKVAPDHPFIQQELEVIEASVEEARAAGSAS-WGELFTGKP 316

  Fly   295 EVYKPLVILMSLFAFQQLTGIFVVIVFAVQISQEAGIEIDPFMCAVLIGLARLITTCPMGYILEW 359
            .::|..::.:.:.:.|||||......:...:....|:. |.|..:::.|:....:||...|.::.
Yeast   317 AMFKRTMMGIMIQSLQQLTGDNYFFYYGTTVFNAVGMS-DSFETSIVFGVVNFFSTCCSLYTVDR 380

  Fly   360 WGRRRAGIISTLGMSVCMFLLAGHSQIEILKEVP------------YLPVVAIVGFIVLSTLGLY 412
            :|||...:...:|| ||.:::  ::.:.:.:..|            ...:|....:|........
Yeast   381 FGRRNCLLYGAIGM-VCCYVV--YASVGVTRLWPNGEGNGSSKGAGNCMIVFACFYIFCFATTWA 442

  Fly   413 TLPFFMISELFPQKVRGPASGLTVA--------VGMFISFVVLKTYPGIKEYLGMSNCFIIFGVM 469
            .:.:.:|||.||.:|:..|..:..|        :|.|..|:.    ..|..|.|    ::..|.|
Yeast   443 PIAYVVISETFPLRVKSKAMSIATAANWLWGFLIGFFTPFIT----GAINFYYG----YVFMGCM 499

  Fly   470 ALFALIFVYLALPETRRRTLLEIEEQFRSG 499
             :||..:|:..:|||:..||.|:.:.:..|
Yeast   500 -VFAYFYVFFFVPETKGLTLEEVNDMYAEG 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8249	NP_001246349.1	MFS	49..479	CDD:119392	101/475 (21%)
CG8249	NP_001246349.1	Sugar_tr	60..496	CDD:278511	104/481 (22%)
HXT3	NP_010632.1	Sugar_tr	65..525	CDD:395036	106/489 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342932
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	4	3.740