DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8249 and HXT10

DIOPT Version :9

Sequence 1:	NP_001246349.1	Gene:	CG8249 / 36742	FlyBaseID:	FBgn0034045	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_116644.1	Gene:	HXT10 / 850536	SGDID:	S000001883	Length:	546	Species:	Saccharomyces cerevisiae

Alignment Length:	524	Identity:	114/524 - (21%)
Similarity:	223/524 - (42%)	Gaps:	64/524 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SNGKQARIVSGLDRLLKTPPPGEQTRAVRRQVIAVILANVG----VFSTGMTLAMPTATLHQLKD 75
            ::.|.:..:|..|.:..||...|.:..:..:.|......:|    :...|......|.|:....:
Yeast    11 TSAKASTSLSRKDEIKLTPETREASLDIPYKPIIAYWTVMGLCLMIAFGGFIFGWDTGTISGFIN 75

  Fly    76 TTE------------PVHLNDSQASWFASVNALSAPIGGLLSGFLLDRIGRKKSLIVLNVLIILA 128
            .|:            ...|:|.:......:..:...:|||..|.|.|..|||..|:.: :|:.:.
Yeast    76 QTDFKRRFGELQRDGSFQLSDVRTGLIVGIFNIGCALGGLTLGRLGDIYGRKIGLMCV-ILVYVV 139

  Fly   129 WILLATPSESDQNAFFWQLIVSRFMLGVGMGLASAPPGVYAAEISVPKTRGSLILGTSISVAGGI 193
            .|::...| ||:   ::|..:.|.:.|:|:|..:.......:|||....||:.:....:.:..||
Yeast   140 GIVIQIAS-SDK---WYQYFIGRIVSGMGVGGVAVLSPTLISEISPKHLRGTCVSFYQLMITLGI 200

  Fly   194 TILYGIGYCIR---------DDFRLIALICCGYQLVALLCVLPLPESHCWLLSKKRVTEAKRSLN 249
            .    :|||..         ..:|:...:|..:.:..::.::.:|||..:|:.|.:..||:|||
Yeast   201 F----LGYCTNYGTKKYSNSIQWRVPLGLCFAWAIFMVIGMVMVPESPRYLVEKGKYEEARRSL- 260

  Fly   250 YFRGFNKSDE--ITHPQVLEEFQLLQKSLQQRNTAVKESFWRNLHE------PEVYKPLVILMSL 306
                 .||::  :|.|.|:.||..:..:::... ||..:.|..|..      |.|...:||.
Yeast   261 -----AKSNKVTVTDPGVVFEFDTIVANMELER-AVGNASWHELFSNKGAILPRVIMGIVIQ--- 316

  Fly   307 FAFQQLTGIFVVIVFAVQISQEAGIEIDPFMCAVLIGLARLITTCPMGYILEWWGRRRAGIISTL 371
             :.|||||......:...|....|:: |.|..::::|.....:|....||::.:|||:..:..:.
Yeast   317 -SLQQLTGCNYFFYYGTTIFNAVGMQ-DSFETSIVLGAVNFASTFVALYIVDKFGRRKCLLWGSA 379

  Fly   372 GMSVCMFLLAGHSQIEIL---KEVP------YLPVVAIVGFIVLSTLGLYTLPFFMISELFPQKV 427
            .|::|..:.|......:.   |:.|      .:.:|....||....:....:.:.:::|.:|.:|
Yeast   380 SMAICFVIFATVGVTRLWPQGKDQPSSQSAGNVMIVFTCFFIFSFAITWAPIAYVIVAETYPLRV 444

  Fly   428 RGPASGLTVAVGMFISFVVLKTYPGIKEYLGMSNCFIIFGVMALFALIFVYLALPETRRRTLLEI 492
            :..|..:.|.......|::....|.|...:|.|..::..|.: :|:..:|:..:.||:..||.|:
Yeast   445 KNRAMAIAVGANWMWGFLIGFFTPFITRSIGFSYGYVFMGCL-IFSYFYVFFFVCETKGLTLEEV 508

  Fly   493 EEQF 496
            .|.:
Yeast   509 NEMY 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8249	NP_001246349.1	MFS	49..479	CDD:119392	101/471 (21%)
CG8249	NP_001246349.1	Sugar_tr	60..496	CDD:278511	106/473 (22%)
HXT10	NP_116644.1	Sugar_tr	52..512	CDD:395036	106/481 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342992
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	3	2.830