DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8249 and YFL040W

DIOPT Version :9

Sequence 1:	NP_001246349.1	Gene:	CG8249 / 36742	FlyBaseID:	FBgn0034045	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_116613.1	Gene:	YFL040W / 850503	SGDID:	S000001854	Length:	540	Species:	Saccharomyces cerevisiae

Alignment Length:	547	Identity:	119/547 - (21%)
Similarity:	217/547 - (39%)	Gaps:	126/547 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 RLLKTPPPGEQTRAVRRQVIAVILANVGVFSTGMTLAMPT-ATLHQLKDTTEPVHLNDSQASWFA 91
            ||.|.|.. :.|:......|..||..||..   |.|.:|: ||....|...|          :|.
Yeast    10 RLPKMPKI-KITKTYEVTKITAILTLVGFI---MGLEVPSLATFLTNKTFNE----------YFK 60

  Fly    92 SVNAL-------SAPIGGLLSGFLL----DRIGR----KKSLIVLNVLIILAWILLATPSESDQN 141
            ....|       |.|:||::..|:.    ||..|    :..:|:.|::.:|             |
Yeast    61 YPTPLQQGLLMGSTPLGGIMGCFICCIMNDRFSRIYQFQSGIIIWNIVTLL-------------N 112

  Fly   142 AFFWQ---LIVSRFMLGVGMGLASAPPGVYAAEISVPKTRGSLILGTSISVAGGITILYGIGYCI 203
            ...|.   |::.|.:.|:.:|..|.....||.|:.....|||.:....:.:..||.:::.:  ||
Yeast   113 FCIWDILGLLICRMIKGMILGNFSILVASYANEVIPRGKRGSTMSYIQLCLTIGILVMHYL--CI 175

  Fly   204 R-----DDFRLIALICCGY--QLVALLCVLPLPESHCWLLSKKRVTEAKR-SLNYFRGFNKSDEI 260
            .     ..|......|.|.  .|:..:....||||:.||:...:::||:. ..|..:.||:|
Yeast   176 ALSLWDSHFAFRIAWCIGIIPGLLFWMASYALPESYHWLVLHGKMSEAQEIQHNLAKKFNES--- 237

  Fly   261 THPQVLEEFQLLQKSLQQRNTAVKE--------SFWRNLHEPEV--------YKPLVILMSLFAF 309
                             |...||.|        .||..:::.:.        :|||::.|:|...
Yeast   238 -----------------QPRDAVPEMSKIELAGDFWIGVNDLDFSKKLPRGSFKPLILGMTLQLL 285

  Fly   310 QQLTGIFVVIVFAVQISQEAGIE--IDPFMCAVLIGLARLITTCPMGYILEWWGRRR-------- 364
            .|.:||.:::.:...|.:..|:|  :..|..::...:..:::..|:.:| ::..|:.
Yeast   286 VQFSGINIILGYITYICEIVGLEGNVKLFTSSIPYFINMVLSLLPITFI-DYTSRKLITLLGGFP 349

  Fly   365 -AGIISTLGMSVCMFLLAG---------HSQIEILKEVPYLP------VVAIVGFIVLSTLGLYT 413
             :|::.|:|   .:|:..|         .|.:..:.|.|::.      ...|||...:|   |.:
Yeast   350 ISGLLITIG---ALFVKYGQDTKPIDGNRSLVWSIGENPFVGGWILTLCFLIVGIFAMS---LSS 408

  Fly   414 LPFFMISELFPQKVRGPASGLTVAVGMFISFVVLKTYPGIKEYLGMSNCFIIFGVMALFALIFVY 478
            :|:...:|:.|.:|:.....:.|..|...:|::....|.:.|.| ....|||||.:.....:.|.
Yeast   409 IPWVYTNEMLPSRVKVKGFAICVTFGWLGNFILTFLCPVMIERL-KGTTFIIFGSLTFLISLSVL 472

  Fly   479 LALPETRRRTLLEIEEQFRSGRSKSQN 505
            :..|||:..::.:|::.|.....:..|
Yeast   473 IWFPETKGMSIEDIDKFFEFESKEGTN 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8249	NP_001246349.1	MFS	49..479	CDD:119392	107/498 (21%)
CG8249	NP_001246349.1	Sugar_tr	60..496	CDD:278511	107/504 (21%)
YFL040W	NP_116613.1	MFS_HXT	28..490	CDD:340914	112/517 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900