DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8249 and INT2

DIOPT Version :9

Sequence 1:	NP_001246349.1	Gene:	CG8249 / 36742	FlyBaseID:	FBgn0034045	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_174313.1	Gene:	INT2 / 839902	AraportID:	AT1G30220	Length:	580	Species:	Arabidopsis thaliana

Alignment Length:	566	Identity:	131/566 - (23%)
Similarity:	235/566 - (41%)	Gaps:	131/566 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 ANVGVFSTGMTLAMPTATLHQLKDTTEPVHLNDSQASWFASVNALSAPIGGLLSGFLLDRIGRKK 116
            |.:|....|....:.:..|..::|..:.|..|........|:....|.:|..:.|:..|::||:.
plant    35 AGIGGLLFGYDTGVISGALLYIRDDFKSVDRNTWLQEMIVSMAVAGAIVGAAIGGWANDKLGRRS 99

  Fly   117 SLIVLNVLIIL-AWILLATPSESDQNAFFWQLIVSRFMLGVGMGLASAPPGVYAAEISVPKTRGS 180
            ::::.:.|.:| |.|:.|.|:.|       .|:|.|..:|:|:|:||....:|.:|.|..|.||:
plant   100 AILMADFLFLLGAIIMAAAPNPS-------LLVVGRVFVGLGVGMASMTAPLYISEASPAKIRGA 157

  Fly   181 LILGTSISVAGGITILYGIGYCIRD---DFRLIALICCGYQLVALLCVLPLPESHCWLLSKKRVT 242
            |:......:.||..:.|.|.....|   .:|.:..|.....|:..:.:..||||..||..|.|..
plant   158 LVSTNGFLITGGQFLSYLINLAFTDVTGTWRWMLGIAGIPALLQFVLMFTLPESPRWLYRKGREE 222

  Fly   243 EAKRSLNYFRGFNKSDEITHPQVLEEFQLLQKSLQ----QRNTAVKESFWRNLHEPEVYKPLVIL 303
            |||..|.  |.::..|      |.:|.:.|:.|::    :..::.|.:..:......|.:.|:..
plant   223 EAKAILR--RIYSAED------VEQEIRALKDSVETEILEEGSSEKINMIKLCKAKTVRRGLIAG 279

  Fly   304 MSLFAFQQLTGIFVVIVFAVQISQEAGIEIDPFMCAVLIGLARLITTCPMG--------YILEWW 360
            :.|..|||..||..|:.::..|.|.||...:  ..|:|:.|    .|..:.        |.::..
plant   280 VGLQVFQQFVGINTVMYYSPTIVQLAGFASN--RTALLLSL----VTAGLNAFGSIISIYFIDRI 338

  Fly   361 GRRRAGIISTLGMSVCMFLLAG-------H----SQIE--------------------------- 387
            ||::..|||..|:.:.:.:|.|       |    |.:|
plant   339 GRKKLLIISLFGVIISLGILTGVFYEAATHAPAISSLETQRFNNISCPDYKSAMNTNAWDCMTCL 403

  Fly   388 -------------ILKEVP-------------------------------YLPVVAIVGFIVLST 408
                         |.||.|                               :..::.:..:|:..:
plant   404 KASSPSCGYCSSPIGKEHPGACWISDDSVKDLCHNENRLWYTRGCPSNFGWFALLGLGLYIIFFS 468

  Fly   409 LGLYTLPFFMISELFPQKVRGPASGLTVAVGMFISFVVLKTYPGIKEYLGMSNCFIIFGVMALFA 473
            .|:.|:|:.:.||::|.:.||...|:........:.:|.:::..:.|.:|.|..|:||||:::.|
plant   469 PGMGTVPWIVNSEIYPLRFRGICGGIAATANWISNLIVAQSFLSLTEAIGTSWTFLIFGVISVIA 533

  Fly   474 LIFVYLALPETRRRTLLEIEE-------QFRSGRSKS-----QNQA 507
            |:||.:.:|||:...:.|||:       :|:..:.||     |||:
plant   534 LLFVMVCVPETKGMPMEEIEKMLERRSMEFKFWKKKSKLVEKQNQS 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8249	NP_001246349.1	MFS	49..479	CDD:119392	119/524 (23%)
CG8249	NP_001246349.1	Sugar_tr	60..496	CDD:278511	123/540 (23%)
INT2	NP_174313.1	SP	25..552	CDD:273317	122/537 (23%)
INT2	NP_174313.1	MFS	33..541	CDD:119392	119/526 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810