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Protein Alignment CG8249 and SLC2A4

DIOPT Version :9

Sequence 1:	NP_001246349.1	Gene:	CG8249 / 36742	FlyBaseID:	FBgn0034045	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001033.1	Gene:	SLC2A4 / 6517	HGNCID:	11009	Length:	509	Species:	Homo sapiens

Alignment Length:	520	Identity:	142/520 - (27%)
Similarity:	236/520 - (45%)	Gaps:	82/520 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PPGEQTRAVRRQVIAVILANVGVFSTGMTLAM---PTATLHQLKDTT----------EPVHLNDS 85
            ||  |.|.....|:||..|.:|....|..:.:   |...:.|..:.|          ..:.....
Human    15 PP--QQRVTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNETWLGRQGPEGPSSIPPGTL 77

  Fly    86 QASWFASVNALSAPIGGLLSGFLLDRI----GRKKSLIVLNVLIILAWILLATPSESDQNAFFWQ 146
            ...|..||...|  :||::|.||:..|    |||::::|.|||.:|...|:...:.:   |.:..
Human    78 TTLWALSVAIFS--VGGMISSFLIGIISQWLGRKRAMLVNNVLAVLGGSLMGLANAA---ASYEM 137

  Fly   147 LIVSRFMLGVGMGLASAPPGVYAAEISVPKTRGSL--------ILGTSISVAGGITILYG----- 198
            ||:.||::|...||.|....:|..||:....||:|        ::|..|:...|:..|.|
Human   138 LILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILIAQVLGLESLLGTASLW 202

  Fly   199 ---IGYCIRDDFRLIALICCGYQLVALLCVLPL-PESHCWL-LSKKRVTEAKRSLNYFRGFNKSD 258
               :|..:     |.||:    |||    :||. |||..:| :.:.....|::||....|:....
Human   203 PLLLGLTV-----LPALL----QLV----LLPFCPESPRYLYIIQNLEGPARKSLKRLTGWADVS 254

  Fly   259 EITHPQVLEEFQLLQKSLQ-QRNTAVKESFWRNLHEPEVYKPLVILMSLFAFQQLTGIFVVIVFA 322
                 .||.|.:..::.|: :|..::.:......|.    :||:|.:.|...|||:||..|..::
Human   255 -----GVLAELKDEKRKLERERPLSLLQLLGSRTHR----QPLIIAVVLQLSQQLSGINAVFYYS 310

  Fly   323 VQISQEAGIEIDPFMCAVLIGLARLITTCPMGYILEWWGRRRAGIISTLGMSVCMFLLAGHSQIE 387
            ..|.:.||:. .|....:..|:...:.|.....::|..|||...::...||..|..|:.  ..:.
Human   311 TSIFETAGVG-QPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMT--VALL 372

  Fly   388 ILKEVP---YLPVVAIVGFIVLSTLGLYTLPFFMISELFPQKVRGPASGLTVAVGMF----ISFV 445
            :|:.||   |:.:|||.||:....:|...:|:|:::|||.|..| ||:   :||..|    .:|:
Human   373 LLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPR-PAA---MAVAGFSNWTSNFI 433

  Fly   446 VLKTYPGIKEYLGMSNCFIIFGVMALFALIFVYLALPETRRRTLLEIEEQFRSGRSKSQNQADVE 510
            :...:..:.|.:| ...|::|.|:.|...||.:|.:||||.||..:|...|.  |:.|..:.:|:
Human   434 IGMGFQYVAEAMG-PYVFLLFAVLLLGFFIFTFLRVPETRGRTFDQISAAFH--RTPSLLEQEVK 495

Fly 511 510
Human 496 495

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.