DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8249 and SLC2A3

DIOPT Version :9

Sequence 1:	NP_001246349.1	Gene:	CG8249 / 36742	FlyBaseID:	FBgn0034045	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_008862.1	Gene:	SLC2A3 / 6515	HGNCID:	11007	Length:	496	Species:	Homo sapiens

Alignment Length:	501	Identity:	124/501 - (24%)
Similarity:	227/501 - (45%)	Gaps:	57/501 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 VIAVILANVGVFSTGMTLAMPTATLHQLKDTTEPVHLNDSQAS---------WFASVNALSAPIG 101
            :.|:.:|.:|.|..|....:..|....:|:.......:...|.         |..||...|  :|
Human    11 IFAITVATIGSFQFGYNTGVINAPEKIIKEFINKTLTDKGNAPPSEVLLTSLWSLSVAIFS--VG 73

  Fly   102 GLLS----GFLLDRIGRKKSLIVLNVLIIL--AWILLATPSESDQNAFFWQLIVSRFMLGVGMGL 160
            |::.    |..::|.||:.|::::|:|.:.  .::.|...::|.:     .||:.|.::|:..||
Human    74 GMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVE-----MLILGRLVIGLFCGL 133

  Fly   161 ASAPPGVYAAEISVPKTRGSLILGTSISVAGGITI--LYGIGYCIRDDFRLIALICCGYQLVALL 223
            .:....:|..|||....||:......:.:..||.:  ::|:.:.:..: .|..|:.....|.|:|
Human   134 CTGFVPMYIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGSE-ELWPLLLGFTILPAIL 197

  Fly   224 --CVLPL-PESHCWLL-SKKRVTEAKRSLNYFRGFNKSDEITHPQVLEEFQLLQ----KSLQQRN 280
              ..||. |||..:|| ::|....||:.|....|..        .|.::.|.::    :..|::.
Human   198 QSAALPFCPESPRFLLINRKEEENAKQILQRLWGTQ--------DVSQDIQEMKDESARMSQEKQ 254

  Fly   281 TAVKESFWRNLHEPEVYKPLVILMSLFAFQQLTGIFVVIVFAVQISQEAGIEIDPFMCAVLIGLA 345
            ..|.|.|..:.:.    :|::|.:.|...|||:||..|..::..|.::||:: :|....:..|:.
Human   255 VTVLELFRVSSYR----QPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVQ-EPIYATIGAGVV 314

  Fly   346 RLITTCPMGYILEWWGRRRAGIISTLGMSVCMFLLAGHSQIEILKE----VPYLPVVAIVGFIVL 406
            ..|.|....:::|..|||...:|...||:.|..|:   :...:||:    :.::.:.||:.|:..
Human   315 NTIFTVVSLFLVERAGRRTLHMIGLGGMAFCSTLM---TVSLLLKDNYNGMSFVCIGAILVFVAF 376

  Fly   407 STLGLYTLPFFMISELFPQKVRGPASGLTVAVGMFISFVVLKTYPGIKEYLGMSNCFIIFGVMAL 471
            ..:|...:|:|:::|||.|..|..|..:........:|:|...:|....||| :..||||....:
Human   377 FEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAHYLG-AYVFIIFTGFLI 440

  Fly   472 FALIFVYLALPETRRRTLLEIEEQFRS---GRSKSQNQADVEMKEV 514
            ..|.|.:..:||||.||..:|...|..   |..:|.....:||..:
Human   441 TFLAFTFFKVPETRGRTFEDITRAFEGQAHGADRSGKDGVMEMNSI 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8249	NP_001246349.1	MFS	49..479	CDD:119392	111/458 (24%)
CG8249	NP_001246349.1	Sugar_tr	60..496	CDD:278511	115/464 (25%)
SLC2A3	NP_008862.1	MFS_GLUT_Class1	12..456	CDD:340989	116/468 (25%)
		Important for selectivity against fructose. /evidence=ECO:0000269\|PubMed:26176916	277..279		0/1 (0%)
		Monosaccharide binding. /evidence=ECO:0000269\|PubMed:26176916	280..286		4/5 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143979
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840