DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8249 and SLC2A2

DIOPT Version :9

Sequence 1:	NP_001246349.1	Gene:	CG8249 / 36742	FlyBaseID:	FBgn0034045	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_000331.1	Gene:	SLC2A2 / 6514	HGNCID:	11006	Length:	524	Species:	Homo sapiens

Alignment Length:	520	Identity:	129/520 - (24%)
Similarity:	235/520 - (45%)	Gaps:	58/520 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 NGKQARIVSGLDRLLKTPPPGEQTRAVRRQVIAVILANVGVFSTGMTLAMPTATLHQLKDTTEPV 80
            |..|..|:|....:|..|.  :..:|:...||            ..|..:||.: :.:.....|.
Human    32 NAPQQVIISHYRHVLGVPL--DDRKAINNYVI------------NSTDELPTIS-YSMNPKPTPW 81

  Fly    81 HLNDSQAS-------WFASVNALSAPIGGL----LSGFLLDRIGRKKSLIVLNVLIILAWILLAT 134
            ...::.|:       |..||::.:  :||:    ..|:|.|.:||.|:::|.|:|.::..:|:..
Human    82 AEEETVAAAQLITMLWSLSVSSFA--VGGMTASFFGGWLGDTLGRIKAMLVANILSLVGALLMGF 144

  Fly   135 PSESDQNAFFWQLIVSRFMLGVGMGLASAPPGVYAAEISVPKTRGSLILGTSISVAGGITI--LY 197
            ......:..   :|..|.:.|:..||.|....:|..||:....||:|.....:::..||.|  :.
Human   145 SKLGPSHIL---IIAGRSISGLYCGLISGLVPMYIGEIAPTALRGALGTFHQLAIVTGILISQII 206

  Fly   198 GIGYCIRD-DFRLIALICCGYQ-----LVALLCVLPLPESHCWLLSK-KRVTEAKRSLNYFRGFN 255
            |:.:.:.: |...|.|...|.:     |:...|    |||..:|..| ....:||:||...||:
Human   207 GLEFILGNYDLWHILLGLSGVRAILQSLLLFFC----PESPRYLYIKLDEEVKAKQSLKRLRGY- 266

  Fly   256 KSDEITHPQVLEEFQLLQKSLQQRNTAVKESFWRNLHEPEVYKPLVILMSLFAFQQLTGIFVVIV 320
              |::|     ::...::|..::.::..|.|..:........:|:::.:.|...||.:||..:..
Human   267 --DDVT-----KDINEMRKEREEASSEQKVSIIQLFTNSSYRQPILVALMLHVAQQFSGINGIFY 324

  Fly   321 FAVQISQEAGIEIDPFMCAVLIGLARLITTCPMGYILEWWGRRRAGIISTLGMSVC-MFLLAGHS 384
            ::..|.|.|||. .|....:.:|...::.|....:::|..|||...:|...||.|| :|:..|..
Human   325 YSTSIFQTAGIS-KPVYATIGVGAVNMVFTAVSVFLVEKAGRRSLFLIGMSGMFVCAIFMSVGLV 388

  Fly   385 QIEILKEVPYLPVVAIVGFIVLSTLGLYTLPFFMISELFPQKVRGPASGLTVAVGMFISFVVLKT 449
            .:.....:.|:.::||..|:....:|...:|:||::|.|.|..|..|..:........:|:|...
Human   389 LLNKFSWMSYVSMIAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRPAALAIAAFSNWTCNFIVALC 453

  Fly   450 YPGIKEYLGMSNCFIIFGVMALFALIFVYLALPETRRRTLLEIEEQF--RSGRSKSQNQADVEMK 512
            :..|.::.|....|:..||:..|.| |.:..:|||:.::..||..:|  :|| |..:.:|.||||
Human   454 FQYIADFCGPYVFFLFAGVLLAFTL-FTFFKVPETKGKSFEEIAAEFQKKSG-SAHRPKAAVEMK 516

Fly 513 512
Human 517 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8249	NP_001246349.1	MFS	49..479	CDD:119392	106/450 (24%)
CG8249	NP_001246349.1	Sugar_tr	60..496	CDD:278511	111/456 (24%)
SLC2A2	NP_000331.1	Sugar_tr	14..499	CDD:278511	120/500 (24%)
		MFS	98..485	CDD:119392	100/405 (25%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	314..320		3/5 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144202
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850