Protein Alignment CG8249 and SLC2A1

DIOPT Version :9

• Sequence 1: NP_001246349.1
• Gene: CG8249 / 36742
• FlyBaseID: FBgn0034045
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_006507.2
• Gene: SLC2A1 / 6513
• HGNCID: 11005
• Length: 492
• Species: Homo sapiens
• Alignment Length: 473
• Identity: 135/473 - (28%)
• Similarity: 234/473 - (49%)
• Gaps: 65/473 - (13%)

  Fly    70 LHQLKDTTEPVHLNDSQASWFASVNALSAPIGGLLS----GFLLDRIGRKKSLIVLNVLIILAWI 130
            :|:..::..|..|.   ..|..||...|  :||::.    |..::|.||:.|::::|:|..::.:
Human    49 VHRYGESILPTTLT---TLWSLSVAIFS--VGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAV 108

  Fly   131 LLATPSESDQNAFFWQLIVSRFMLGVGMGLASAPPGVYAAEISVPKTRGSLILGT--SISVAGGI 193
            |:..   |.....|..||:.||::||..||.:....:|..|:|....||:  |||  .:.:..||
Human   109 LMGF---SKLGKSFEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGA--LGTLHQLGIVVGI 168

  Fly   194 TI--LYGIGYCI--RDDFRLI-------ALICCGYQLVALLCVLPL-PESHCWLL-SKKRVTEAK 245
            .|  ::|:...:  :|.:.|:       ||:.|        .|||. |||..:|| ::.....||
Human   169 LIAQVFGLDSIMGNKDLWPLLLSIIFIPALLQC--------IVLPFCPESPRFLLINRNEENRAK 225

  Fly   246 RSLNYFRGFNKSDEITHPQVLEEF-QLLQKSLQQRNTAVKESFWRNLHEPEVYKPLVILMSLFAF 309
            ..|...||   :.::||.  |:|. :..::.::::...:.|.|    ..|...:|::|.:.|...
Human   226 SVLKKLRG---TADVTHD--LQEMKEESRQMMREKKVTILELF----RSPAYRQPILIAVVLQLS 281

  Fly   310 QQLTGIFVVIVFAVQISQEAGIEIDPFMCAVLIGLARLITTCPMGYILEWWGRRRAGIISTLGMS 374
            |||:||..|..::..|.::||:: .|....:..|:.....|....:::|..|||...:|...||:
Human   282 QQLSGINAVFYYSTSIFEKAGVQ-QPVYATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMA 345

  Fly   375 VCMFLLAGHSQIEILKEVP---YLPVVAIVGFIVLSTLGLYTLPFFMISELFPQKVRGPASGLTV 436
            .|..|:.  ..:.:|:::|   ||.:|||.||:....:|...:|:|:::|||.|..| ||:   :
Human   346 GCAILMT--IALALLEQLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPR-PAA---I 404

  Fly   437 AVGMF----ISFVVLKTYPGIKEYLGMSNCFIIFGVMALFALIFVYLALPETRRRTLLEIEEQFR 497
            ||..|    .:|:|...:..:::..| ...||||.|:.:...||.|..:|||:.||..||...||
Human   405 AVAGFSNWTSNFIVGMCFQYVEQLCG-PYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIASGFR 468

  Fly   498 SGRSKSQNQADVEMKEVF 515
            .|   ..:|:|...:|:|
Human   469 QG---GASQSDKTPEELF 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8249	NP_001246349.1	MFS	49..479	CDD:119392	120/435 (28%)
		Sugar_tr	60..496	CDD:278511	128/452 (28%)
SLC2A1	NP_006507.2	MFS_GLUT_Class1	14..458	CDD:340989	124/443 (28%)
		Monosaccharide binding. /evidence=ECO:0000269|PubMed:24847886	282..288		4/5 (80%)
		Disordered. /evidence=ECO:0000305|PubMed:30197081	468..492		6/19 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144185
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840