DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8249 and CG6901

DIOPT Version :9

Sequence 1:	NP_001246349.1	Gene:	CG8249 / 36742	FlyBaseID:	FBgn0034045	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_650531.1	Gene:	CG6901 / 41977	FlyBaseID:	FBgn0038414	Length:	485	Species:	Drosophila melanogaster

Alignment Length:	553	Identity:	111/553 - (20%)
Similarity:	199/553 - (35%)	Gaps:	156/553 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LLKTPPPGEQTRAVRRQVIAVILANVGVFST------------------GMTLAMPTATLHQLKD 75
            ::.|.||.|..:.      ||...|.|.|:.                  ||.:|   |:|    .
  Fly    18 IIATAPPPEPRKP------AVTTNNRGYFTRINKQNYASYTVFFLFIYGGMDMA---ASL----G 69

  Fly    76 TTEPVHL---NDSQASWFASVNALSAPIGGLLSGFLLDRIGRKKSLIVLNVLIILAWILLATPSE 137
            .::|..:   .:....||..|      |.|.|:..|......|....|...|:.|...::.|.::
  Fly    70 WSQPYSVLLFTEYSYCWFVGV------IIGALATTLTMSFLPKLVYYVFGALMQLTGSIIFTAAD 128

  Fly   138 SDQNAFFWQLIVSRFMLGVGMGLASAPPGVYAAEISVPKTRG--------SLILG---------- 184
                  :...:.:|::.|:|:||.:.|..::.||::....||        .|.||
  Fly   129 ------YSACLAARYLAGLGIGLITVPFLIHNAEVASNNLRGVNGGMEQCGLALGIFFQVIFTTE 187

  Fly   185 -TSI---------SVAGGITILYGIGYCIRDDFRLIALICCGYQLVALLCVLPLPESHCWLLSKK 239
             ||:         .:.|.:..|:|:.        :.||:.               ||..:.|.:.
  Fly   188 WTSLIDSNPNEIHGIIGIVVSLFGLA--------MTALVV---------------ESPIFFLRRN 229

  Fly   240 RVTEAKRSLNYFRGFNKSDEITHPQVLEEFQLLQKSLQQRNTAVKESFWRNLHEPEVYKPLVILM 304
            ....|::|.......|...             :..:|::....|.||..|.|.| |:...::..:
  Fly   230 MENRAQQSQEKLLRHNPGG-------------VSAALKEARRYVAESDNRTLGE-ELVASVMPFL 280

  Fly   305 SLFAFQQLTGIFVVIVFAVQISQ---------EAGIEIDPFMCAVLIGLARLITTCPMGYILEWW 360
            .:..|:    .||...|::.::.         |.|:.:.|.   .|.|:.|:|........|:..
  Fly   281 KMLLFR----CFVAFSFSLPLTMSIISSTAVAEKGLSLWPI---YLFGVLRVIGVMVALIFLDTL 338

  Fly   361 GRRRAGIISTLGMSVCMFLLAGHSQIEILKEVPYLPVVAIVGFIVLSTLGLYTLPF------FMI 419
            ||:...::..|.|:..|..|||          .|..|..::.|.::::.....|.|      |:.
  Fly   339 GRKAVSLVGLLVMAGLMLGLAG----------LYANVTNLISFNLMTSACNIALAFQVFAGLFVC 393

  Fly   420 S------ELFPQKVRGPASGLTVAVGMFISFVVLKTYPGIKEYLGMSNCFIIFGVMALFALIFVY 478
            |      |.||.:|:....|:.|.:...:..||:.....:.........|:..|::.|..:||..
  Fly   394 SSSAYMGEAFPMRVKSFLVGVIVIIEQIVHIVVIACVSSVPNKDFFFQYFLAVGIIMLVGMIFFT 458

  Fly   479 LALPETRRRTLLEIEEQFRSGRSKSQNQADVEM 511
            :::|||::.||.:...:|       |...||:|
  Fly   459 VSMPETKKMTLRKAGHRF-------QKWYDVQM 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8249	NP_001246349.1	MFS	49..479	CDD:119392	96/499 (19%)
CG8249	NP_001246349.1	Sugar_tr	60..496	CDD:278511	97/487 (20%)
CG6901	NP_650531.1	Sugar_tr	85..469	CDD:278511	89/449 (20%)
CG6901	NP_650531.1	MFS	<272..457	CDD:119392	39/201 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471781
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740